PTD-DBM bụ a ọgwụgwọ peptide A na-ejikarị agwọ ụdị ntutu dị iche iche.
Usoro amino acid ya sitere na nghota miri emi nke pathophysiology nke androgenic alopecia, tinyere ụdi nchoputa na ngwa nke peptides na-abanye n'ime cell (CPP).
agbakwunyere usoro bara ụba arginine n'ime PTD-DBM, na-enye ya ikike ịbanye cell.
Njikọ njikọ (site na njikọ glycine) na ngalaba peptide DBM bioactive akọwapụtara na-enye njirimara arụ ọrụ abụọ peptide zuru oke.
Nke polyarginine Usoro na N-terminus na-enye ohere ịbanye nke ọma nke ma stratum corneum nke anụ ahụ na akpụkpọ ahụ sel niile na-esote.; ezi nnyefe nke ibu nọ n'ọrụ ka dermal papilla cell (na niches sel sel jikọtara ya) na-enweta.
Nchọpụta na njikọ nke PTD-DBM na-anọchite anya mgbanwe dị ịrịba ama na ọgwụgwọ ntutu isi – na-akpali site na usoro ma ọ bụ mmetụta vasodilator dị mfe, iji dozie microenvironmental na mmezigharị nke ntutu isi n'onwe ya.
Usoro
Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Lys-Thr-Gly-His-Gln-Ile-Cys-Lys-Phe-Arg-Lys-Cys
Nọmba CAS
1609454-11-6
Usoro ihe omimi
C124H225N61O28S2
Ibu molekụla
3082.683
Nnyocha metụtara PTD-DBM Peptide
Akụkụ carboxyl-terminal DBM na-arụ ọrụ dị ka ọnyà molekụla akọwapụtara, na-ewere ihe karịrị BMP ụmụ irighiri ihe – intracellular na extracellular – neutralizing ha.
E si otú a kpọchie akara nrịbama uto n'okpuru ala ozugbo.
DBM na-ebelata mgbochi a, na-agbatị usoro anagen (uto) na igbochi mgbanwe catagen/telogen akaghi aka.
Mmetụta na-egbochi ntutu isi nwere ike pụta: ibu, A na-emepụta ntutu na-agbanwe agbanwe karị.
Nke abuo, A na-ahụ mmụgharị nke mkpụrụ ndụ stem follicle ntutu na-ehi ụra, site n'ịkwalite mmụba ha na ọdịiche dị n'ime ndị mụrụ ntutu isi ọhụrụ na-akwado.
Kpọmkwem, BMPs bụ ihe ndị bụ isi na-egbochi uto ntutu; PTD-DBM na-ejikọ ma gbochie ịgbalite akara ngosi ndị a, ya mere mmetụta niile a kpọtụrụ aha n'elu na-esote dịka nsonaazụ ya kpọmkwem.
N'oge usoro uto ntutu nkịtị, anagen (oge uto) Catagen na-aga nke ọma (ụdị nlọghachi azụ).
Ọkpụkpụ protein morphogenetic (BMPs) nrịbama na-ekere òkè dị ukwuu n'ibelata oge anagen a; ntinye aka na telogen, ezi oge izu ike, bụ kpọmkwem nsonaazụ.
Nke kacha mma, nkenke, Ajị agba agba dị obere na-esote na okirikiri ndị na-esote.
PTD-DBM na-eme ihe iji gbochie ụzọ mgbaàmà a akọwapụtara.
Ịgbatị oge na-arụsi ọrụ ike bụ otu n'ime usoro mmemme ya bụ isi.
Ịga n'ihu na-emepụta ntutu na-esiwanye ike karị ga-ekwe omume; ịkwụsị usoro pathological nke ntutu isi n'onwe ya bụ njedebe njedebe nke ogige ahụ chọrọ iji nweta.
A na-echekwa njupụta ntutu isi.
COA
HPLC
MS
