The significance of peptide modification: chemical modification is used to maintain or enhance the biological activity of peptides, while optimizing their effective utilization in the body, reducing toxic side effects, prolonging the duration of action, and changing the distribution in the body.

Peptide modification is also an important means of designing peptide drugs. Chemically modified peptides can not only maintain high biological activity, but also effectively avoid the shortcomings of immunogenicity and toxicity. At the same time, chemical modification can give peptides some new excellent properties, providing more reasonable and richer ideas for the development of peptide drugs, including but not limited to C-terminal modification, N-terminal modification, intermediate residue modification, cyclization modification, amidation, acetylation, biotin and FITC labeling, disulfide bond modification, multiple phosphorylation, methylation modification and other methods