Liphetoho tsa C-terminal Peptide li Senola likarolo tse tobileng le tse sa tobang tsa Hedgehog Morphogen Cholesterylation.

Hedgehog (Hh) li-morphogens li ameha ho nts'etsopele ea embryonic le biology ea stem cell le, haeba e sa laoloe hantle, e ka tlatsetsa ho kankere. Phetoho e 'ngoe ea bohlokoa ea ka morao ho phetolelo e nang le tšusumetso e matla ho biofunction ea Hh ke C-terminal cholesteroylation nakong ea biosynthesis.. Khopolo-taba ea hajoale ke hore karolo ea k'holeseterole ke ntho e ka sehloohong e amanang le Hh le letlapa la kantle la plasma la lisele tse hlahisang., cell-surface Hh multimerization, le sepalangoang le matshwao a yona. Leha ho le joalo, ha ho etsoe qeto ea hore na karolo ea k'holeseterole e ameha ka ho toba lits'ebetsong tsena kaofela, hobane ho its'etleha ha bona ka tsela e fapaneng ho hlahisa monyetla o mong oa hore k'holeseterole e qale lits'ebetso tsa pele ka kotloloho le hore lits'ebetso tsena li ka tsamaisa mehato ea morao-rao ea pontšo ea Hh ntle le lipid.. Re hlahisitse mefuta e fapaneng ea C-terminal Hh peptide mme ra hlokomela hore li-peptide tsena tse nang le k'holeseterole ka mokhoa o fapaneng li sitisitse mekhoa e mengata ea morao-rao ea ho hlahisa lisele le Hh biofunction ho nts'etsopele ea mahlo le mapheo a Drosophila melanogaster.. Hape re fumane hore palo e kholo ea Hh e arohaneng le li-tag tsa cholesteroylated peptide in vitro le in vivo le tse nang le mefuta e fapaneng ea Hh e hlokang likarolo tsa eona tsa C-cholesterol.. Mokhoa oa rona o tiisa hore Hh cholesterol e bohlokoa nakong ea mehato ea pele ea tlhahiso ea Hh le khōlo, empa hape e fana ka maikutlo a hore e ka sebelisoa bakeng sa ho amohela pontšo ea Hh ha ho amohela lisele..