Cardiogen ke peptide ea maiketsetso ea bioactive e nang le litlamorao tsa ts'ireletso ea pelo le matla a ho khutlisa. E tsoa ho lipatlisiso tse tsoelang pele tsa batho ho pathogenesis mafu a pelo, ke sethethefatsi se entsoeng ka botlalo sa peptide.
Tšireletso ea pelo, kapa ka bophara ho feta ts'ireletso ea pelo dinthong tse phelang, e kenyelletsa phetiso ea litsela tse itseng tsa matšoao; lihomone le li-neurotransmitters ke tsona tse ka sehloohong tse kenang lipakeng.
Cardiogen e ne e etselitsoe ho tloha qalong ho etsisa litsela tsena kapa ho kenya tšebetsong protheine ea mats'oao ka kotloloho(s) ho fihlela tshireletso e itseng.
Ho se be sethethefatsi se nkiloeng ka tlhaho, mefokolo eohle ea tlhaho e amanang le li-peptide tsa tlhaho (ho senyeha ka potlako, halofo ya bophelo bo bokgutshwane, tlase bioavailability) li hlōloa ka tekanyo e khōlō.
Boithuto ba preclinical bo bontšitse phokotso e kholo ho lefu la myocardial infarction boholo, mosebetsi o ntlafetseng oa ventricular ea le letšehali, thibelo ya bobe ho nchafatsa ventricular, le tšireletso khahlanong le apoptosis le necrosis boemo ba cardiomyocyte.
Ho boetse ho bontšoa matla a matla a antioxidant, ho fokotsa mefuta eohle ea tšenyo ea oxidative ho e 'ngoe ea tsona li-cardiomyocytes kapa lisele tse tsamaeang le vascular endothelial.
Liphuputso tsa morao-rao li bontša ho ntlafatsa metabolism ea matla a myocardial – ho ntlafatsa ts'ebetso ea mitochondrial le tlhahiso ea matla e khahlang haholo.
Hajoale ho ntse ho batlisisoa litlamorao tsa antifibrotic.
Multidimensional, Synergistic cardioprotective le matla a phekolo ke seo Cardiogen e se emelang.
Tatelano
Ala-Glu-Asp-Arg
Nomoro ea CAS
/
Foromo ea limolek'hule
C18H31N7O9
Boima ba Molek'hule
489.486
Patlisiso ea Cardiogen Peptide
1.Ho phekola mafu a pelo le a latelang leqeba la reperfusion
Kotsi ea reperfusion ka boeona ke ntlha ea ho qetela eo ba bangata ba batlang ho e phekola hona joale.
Li-blockages ka har'a tsamaiso ea pelo li lebisa ho ischemia/hypoxia lefu la myocardium; tsosoloso e tobileng ea phallo ea mali (ho buoa kapa ka tsela enngwe) e baka tshenyo ena e kgolo.
lefu la pelo, ka ho kenya ts'ebetsong mekhoa e boletsoeng ka holimo ea intracellular (PI3K-Akt ho ba ka sehloohong har'a bona), e etsisa likarabelo tsa 'mele tsa ho itšireletsa.
Ho buloa ha pore ea phetoho ea mitochondrial permeability(mPTP) ho ba emong wa ho qetela, mehato e kotsi e ke keng ea etsolloa lefung la cardiomyocyte, e thibetsoe ka katleho.
Ho pholosa mokuli ho tsoa ka botlalo kapa haufi le ho tlala infarction ke sephetho se nepahetseng – e nyane, ho feta e tloaelehileng’ boholo ba myocardium le tsohle tse latelang, ke sepheo sa 'nete sa phekolo ea cardiogenic.
2.Ho thibela apoptosis
Mehlala ea khatello ea maikutlo e sa foleng le kotsi ea reperfusion, Cardiogen e bontšitsoe hore e hatella apoptosis haholo.
Ba kenya tshebetsong senotlolo ka ho toba kinase joalo ka Akt, thibela ts'ebetso ea pro-apoptotic protheine ka phosphorylation, 'me maemong a mang e ntlafatsa ts'ebetso ea protheine ea anti-apoptotic.
Mofuta oa khatello e tobileng ea boemo ba li-hormone ea apoptosis e finyelloa ka mekhoa ena.
Patlisiso ena e bonts'a monyetla o moholo oa lefu la pelo – ho pholosa bakuli ba pelo ba kulang haholo e le ts'ebeliso e le 'ngoe, ho laola likarolo tse fapaneng tsa lefu la pelo le sa foleng, liehang (haeba e sa emise) tahlehelo ea lisele tsa myocardial, le ka ho eketsa ho lieha mefuta eohle ea ho hloleha ha pelo ho tsoelang pele.
3.Ho ntlafatsa metabolism ea matla a pelo
Cardiogens e ntlafatsa metabolism ea matla ka har'a lisele tsa pelo; thibelo ea pele ea ho bula mPTP ke mokhoa o ka sehloohong o sebelisetsoang morero ona.
Ho fokotsa tšenyo ea oxidative ho ketane ea lipalangoang tsa elektronike ea mitochondrial ho lumella mitochondria ho boloka bokhoni ba membrane le ho isa bokhabaneng bo boholo ba sebopeho..
E sebetsang hantle adenosine triphosphate (ATP) tlhahiso ke ka nako eo khoneha, mofuta o tsitsitseng oa matla o fanoang ho pelo e hlolehang.
Khokahano e tsitsitseng ea pelo le mefuta eohle e amanang le ts'ebetso ea pelo e khuts'oane / e telele e itšetlehile ka phepelo ena e tsitsitseng ea matla..
4.Antioxidant le Anti-inflammatory Effects
Litlamorao tse sa tobang tsa antioxidant li boetse li bontšoa ke cardiogen.
Ho kenya tshebetsong ka ho otloloha ha ditsela tse itseng tsa matshwao (Akt ke mohlala o ka sehloohong) e lebisa tlhokomelong ea litsamaiso tsa 'mele tsa endogenous antioxidant.
Glutathione peroxidase le li-enzyme tse ling tse tšoanang li bona ho eketseha ha polelo, ho theha e ‘ratehang haholoanyane’ tikoloho bakeng sa lisele tsa pelo.
Thibelo ea Myocardial Fibrosis le Ventricular Remodeling: Cardiac fibrosis ka boeona ke sesosa se ka sehloohong sa lefu la pelo le bohloko kapa ho qetella ho hloleha ha setho sa 'mele.
Khatello ea nako e telele e bakileng fibrosis le ho lokisoa ha ventricular ho latela bonyane ke karolo e itseng e ikarabellang bakeng sa mohato oa ho qetela oa lefu la pelo..
Ketso ea Cardiogen ka lintlha tse boletsoeng ka holimo (anti-apoptotic ho ba eona e ka sehloohong) le thibelo e tobileng ea matšoao a pro-fibrotic, ke sebaka sa lipatlisiso se bohlokoa haholo ebile se ngotsoe hantle.
Bokhoni ba Cardiogen ba ho lieha kapa ho thibela myocardial fibrosis ke karolo ea ts'episo ea eona ea kalafo ka kakaretso..
COA
HPLC
MOF
