Dihexa ke ntho e ncha li-oligopeptides bioactive peptide e etselitsoeng ho phekola mafu a neurodegenerative.
Ea pele e tlalehiloeng ka 2012, e simolohile ho batlisisang le ho latela boenjineri ba morao ba angiotensin IVLiphello litseleng tse fapaneng tsa matšoao a boko.
Moqapi o seng oa tlhaho oa limolek'hule oa Dihexa o ntlafatsa khetho e khethehileng ea sele ho ea libakeng tse lebisitsoeng; lintlafatso tse kholo tsa botsitso ba metabolism li tlalehiloe, bioavailability e matla ea molomo le ho kenella ha tsamaiso ea methapo e bohareng e le tse peli tsa litšobotsi tsa eona tse hlokomelehang.
Ho sebetsa e le sesebelisoa se sebetsang haholo le se matla c-Met receptor agonist, likarolo tsohle tsa tsoelo-pele ea tsamaiso ea methapo e bohareng, ho lokisa le ho nchafatsa haholo, ba bebofatswa ke yona.
Tatelano
Hexanoyl-Tyr-Ile-Ahx-NH2
Nomoro ea CAS
1401708-83-5
Foromo ea limolek'hule
C27H44N4O5
Boima ba Molek'hule
504.67
Lipatlisiso tsa Dihexa Peptide
1.Matla a Phekolo le Mekhoa ea Ts'ebetso
Ho ntlafatsa bokhoni ba ho ithuta le ho hopola ke e 'ngoe ea litlamorao tse bonoang.
Tšenyo ea neuronal e tsoang ho lintlha tse ngata – khatello ea oxidative, β-amyloid (Aβ) chefo e amanang le yona, ho se sebetse ha mitochondrial – e ka thibeloa ke Dihexa.
Likopo tsa theory bakeng sa ho alafa mefuta e mengata e fapaneng ea mafu a methapo ea kutlo (Lefu la Alzheimer, Lefu la Parkinson, Huntington ke mehlala e meholo) latela mokhoa ona oa lipatlisiso.
Lisele tsa pele tsa oligodendrocyte karohano, tsosoloso e amanang le myelin, phallo ea mali ea boko / ntlafatso ea phepelo ea matla le ho isa tekanyong e itseng litlamorao tse khahlanong le hlahala kaofela li tšehetsoa ke bopaki ba hajoale..
Monyetla o moholo o teng bakeng sa Dihexa e le moemeli oa phekolo.
2.Ntlafatso ea ho Ithuta le Mehopolo
Sistimi ea HGF/CMet ke ntlha ea bohlokoa ea ho khothaletsa nts'etsopele ea hippocampal.
Tekong ea mokoloko, sehlopha sa Dihexa se bontšitse bokhoni bo matla ba ho ithuta; ho fumana liforomo tse patiloeng, ba entse joalo ka nako e khuts'oane haholo ho feta sehlopha sa taolo.
Setšoantšo sa HGF-Tg sehlopha ka boeona se bontšitse ho nepahala ho phahameng le ho phehella ho matla ho ithuta.
Ha ho bapisoa le taolo ea mofuta o hlaha, ho eketseha ha polelo ea HGF ho lebisitse ho phahama ho hlakileng ha lisele tse khethehileng tsa hippocampal receptor – ho matlafatsa ho ithuta le mohopolo e le e 'ngoe ea litlamorao tse ntle tse bonoang.
3.Ho khothaletsa Synapsis le Dendrite Formation
Joalo ka boemo ba kholo ea hepatocyte (HGF)/c-Met receptor agonist, Dihexa e kenya tšebetsong litsela tse fapaneng tsa lipontšo (PI3K/Act ho ba ka sehloohong, MAPK/ERK bobeli), ka kotloloho ho nolofatsa tse ncha synapse le ka tekanyo e kgolo dendrite sebopeho ka har'a li-neurone.
Ho lahleheloa ke dendrite ke sesosa se ka sehloohong se tobileng sa mefuta eohle ea ho fokotseha ha mohopolo o tsitsitseng; bothata ba ho ithuta bo latela haufi-ufi.
Liteko tsa liphoofolo li supa hore Dihexa e na le monyetla oa 'nete oa ho phekola mafu a itseng a Alzheimer's.
4.Neuroprotection le Anti-apoptosis
Maloetse a Neurodegenerative a tsoela pele ka litsela tse ngata – khatello ea oxidative, mefuta e fapaneng ea ho se sebetse ha mitochondrial, le phello e sa tloaelehang ho bokellana ha protheine e lebisang ho neuronal apoptosis.
Dihexa, ka ho susumetsa tsamaiso ea HGF e boletsoeng ka holimo, ka katleho e sitisa mokhoa ona; inhibiting (kapa ho dieha) phetiso e felletseng ea mats'oao a apoptotic ke karolo ea bohlokoa ea ts'ebetso ea eona ea methapo ea kutlo.
5.Ho khothaletsa ntlafatso ea myelin
Myelin ke hore sheath e mafura wrapping the axon ea neuron, phetiso e nepahetseng le e potlakileng ya matshwao a methapo ho itshetlehile ka yona.
Mafu a khaello ea Myelin a lebisa mefuteng eohle ea methapo ea kutlo.
Lisele tsa pele tsa oligodendrocyte (le ho isa ntlheng, lisele tsohle tsa methapo) e ka khothaletsoa ho khothaletsa nchafatso ea myelin, le Dihexa e na le phello e hlakileng le e ntle tsamaisong ea methapo ka kakaretso.
COA
HPLC
MOF
