Epithalon ke bioactive tetrapeptide e sibollotsoe le ho hloekisoa ka lithuto tse sebetsang tsa tšoelesa ea phaene. Tatelano e khethehileng ea amino acid ke Ala-Glu-Asp-Gly.
Lilemong tsa bo-1980, Bo-rasaense ba Russia ba ile ba etsa lipatlisiso tse hlophisitsoeng mabapi le karolo ea taolo ea pineal gland ka har'a lits'ebetso tse fapaneng tsa botsofali.. Bioactive molek'hule e nyane likhechana tsa peptide li ile tsa aroloa 'me tsa hlalosoa e le karolo ea mosebetsi ona;
Epithalon ka boeona e ile ea etsoa ho tloha sekhechana se seng se joalo se sebetsang. Ntlafatso ea peptide ena e lebisitse katlehong ea eona ea maiketsetso.
Ke karolo ea sehlopha se hlalositsoeng haholoanyane sa li-peptide tsa bioregulatory, Epithalon e hlokomela ka ho khetheha mefuta e itseng ea polelo ea lefutso le ho latela mesebetsi ea cellular.
E pharalletseng in vivo le mefuta e fapaneng ea liteko tsa in vitro li bonts'itse hore e etsa hore polelo ea telomerase reverse transcriptase (TERT) – karolo ea catalytic ea telomerase – e leng mokhoa o haufi oa mantlha oa bokahohle botsofali ba cellular.
Telomerase synthesize (mme ho isa tekanyong e kgolo e lefella) tahlehelo ea bolelele ba telomere ka chromosome fella; phetoa karohano ea lisele e bakang tahlehelo ena. Ho eketsa bolelele ba telomere ka kotloloho ho ntlafatsa meeli ea in vitro replication ea lisele, ho liehisa lipontšo tsohle tse amanang le tsona’ ea botsofali ba 'nete ba lisele.
Mefuta ea liphoofolo e bontšitse liphello tse kholo ho tloha Epithalon: katoloso ya nako ya bophelo ya baeloji, bonyane phetoho e itseng ea ho fokotseha ho amanang le lilemo, taolo ea sesole sa 'mele, thibelo ea (ba bang) tumorigenesis, le ho fihla ntlheng ea ho khutlisa tekano ea endocrine.
Ho fetola liphatsa tsa lefutso tsa bohlokoa le ho ba le (ho isa tekanyong e itseng) thepa ea antioxidant ho lumeloa hore ke lisosa tse ka sehloohong tsa tsohle tse ka holimo. Epithalon, ka hoo, e ntse e le motsoako oa bioactive o nkoang haholo meleng eohle ea lipatlisiso tse khahlanong le botsofali.
Tatelano
H-Ala-Glu-Asp-Gly-OH
Nomoro ea CAS
307297-39-8
Foromo ea limolek'hule
C14H22N4O9
Boima ba Molek'hule
390.35
Lipatlisiso tsa Epithalon
1.Liphello tse Khahlanong le Botsofali
Li-telomere ke li-protein tse khethehileng tsa DNA-protein complexes tse qetellong ea li-chromosome tsa eukaryotic. Mosebetsi oa bona o ka sehloohong ke ho sireletsa chromosome hore e se ke ea tsejoa e le tšenyo ea DNA; ho thibela mofuta ofe kapa ofe oa ho senyeha ha chromosomal ho bohlokoa haholo. Karohano e 'ngoe le e' ngoe ea sele e fella ka khutsufatso e nyane ea li-telomere tsena.
Ho fihlela bolelele bo fokolang ho etsa hore motho a ikatise senescence kapa mekhoa e fapaneng ea ho arabela tšenyo ea DNA; ho tšoaroa hoa karohano ea lisele (ka ho khetheha ho Karolo ea G1) 'me secretion e latelang ea lihomone tse' maloa tse amanang le botsofali ba lisele ke phello ea ho qetela.
Telomerase, a ribonucleoprotein reverse transcriptase, e khothalletsa tlhahiso ea DNA ea telomere le ho e khutlisetsa qetellong ea chromosome. – ho lefella kgutsufatso e fetileng. Epithalon e kenya tšebetsong mofuta oa TERT o ikarabellang ketsahalong ena, ha e le hantle e laolang telomerase.
Lithuto tsa mohlala oa liphoofolo li bonts'itse liente tsa nako le nako ho lelefatsa nako ea bophelo haholo, liehisa likarolo tse ngata tsa ho theoha 'meleng ho amanang le lilemo, fokotsa (haufi le ho fela phediso) li-pathologies tse fapaneng tsa botsofali, le ho pota-pota ka hohle ho fetola litsela tsa bohlokoa tsa senescence.
2.Antioxidant le anti-inflammatory liphello
Drosophila melanogaster ke mohlala o hlophisitsoeng hantle oa ho lekola lipid peroxidation maemo. Nakong ea sethala sa larva keketso ea 0.00001% Epithalon e atlehile ho thibela keketseho e neng e lebelletsoe ho peroxidation e boletsoeng. Li-antioxidant tse matla le tse ngata tse khahlanong le ho ruruha li bontšoa ke sephetho sena.
Boithuto bo fapaneng bo shebaneng le maemo a fapaneng a Epithalon mabapi le nts'etsopele ea pele e fumane hore lintsintsi tse holileng le tse tsofetseng ke tsona tse amohelang litlamorao tsa eona.. Genotoxicity e ne e sa hlokomeloe.
3.Monyetla oa Antitumor
Epithalon e fokotsa ho se tsitse ha chromosomal; ho hlakoloa ha chromosomal le mefuta e fapaneng ea phetoho e ama ka kotloloho DNA ea tlhaho. Khaello ea DNA hangata ke sesosa se ka sehloohong sa lisele lefu la kankere.
Boithuto ba nako e telele bo foufetseng habeli bo bonts'itse phokotso e tobileng ea liketsahalo tsa hlahala le mefuta e fapaneng ea kalafo ea Epithalon.. Karolo e sebetsang ea ho thibela likarolo tse khethehileng tsa nts'etsopele ea hlahala e boetse e hlokomeloa. Ho phekola lihlahala tsa boholo bo tšoanang le sebaka, Phekolo ea nako e telele le Epithalon e ile ea fella ka kholo e nyane haholo e ileng ea latela.
4.Liphello tsa Endocrine Regulatory
Epithalon ke bioactive agent e khonang ho susumetsa haholo boitšoaro ba lisele tsa gastric endocrine.
Teko e sebelisang likhoto tsa lilemo tse mahareng e bone tšoelesa ea pineal e tlositsoe lithutong; sehlopha sa liteko se ile sa fumana tsamaiso e tsoelang pele ea Epithalon. Palo ea lisele tse hlahisang gastrin le tse hlahisang somatostatin e bonts'itse paballo e phethahetseng ea se batloang. lisele tsa endocrine mefuta ha e bapisoa le taolo. Ho fokotsa tahlehelo e haufi-ufi ea lisele tsena ka mor'a ho tlosoa ha phaene ke pontšo e hlakileng ea phello ea Epithalon bonyane mofuta o itseng oa boitšoaro ba lisele tsa gastric endocrine..
5.Tsosoloso ea Lithane le Mosebetsi oa Tokiso
Epithalon e bontša ho tšoana ho itseng ho li-retinoids. Ho hlahloba morphology ea lisele tsa retina ho litoeba tsa lilemo tse mahareng, Phekolo e tsoelang pele ea Epithalon e bolokile likarolo tsohle tsa retina; timetso e feletseng ea retina e ile ea bonoa litoeba tse sa phekoloang.
Likarolo tsa retina tse tšoaroang ka Epithalon li bolokile tsa tsona botshepehi, ka keketseho ho se ka hlalosoang feela e le 'libaka tsa ts'ebetso tse sebetsang'. Teko ea kliniki ea bakuli (162 kakaretso, lilemo tse fapaneng) ha joale retinitis pigmentosa e ntse e lateloa; ntlafatso ea pono ea 0.15-0.25 li tlalehiloe, hammoho le ts'ebetso eohle ea pono e pota-potileng (ho isa tekanyong e itseng). Litla-morao ha lia tlalehoa.
6.Ho ntlafatsa ts'ebetso ea metabolic
Ho 2004, teko e 'ngoe ea litšoene tsa macaque e bontšitse phello ea Epithalon ka ho khetheha maemong a tsoekere ea mali. Litšoene tse nyane le tse tsofetseng li ile tsa fumana liente tsa intramuscular tsa Epithalon; ho ile ha nkoa litekanyo tse latelang tsa tsoekere ea mali.
Pele ho tsamaiso, litšoene tse tsofetseng li ne li bonts'a maemo a tsoekere ea mali a holimo haholo. Litekanyo tsa ka mor'a ho noa li senotse phokotso e hlakileng le e hlakileng ea maemo ana bakeng sa litšoene tsa khale. Ho khutlela motheong (bonyane ka nakoana) e ile ea hlokomeloa khoeli ka mor'a hore tsamaiso e khaotse.⁶
7.Molao oa tsamaiso ea 'mele ea ho itšireletsa mafung
Lithuto tse sebelisang litloaelo tsa organotypic tsa li-fibroblasts tsa rat tsa mantlha le litlatsetso tse fapaneng tsa letlalo la likhoto li bonts'a mofuta o mong oa ts'ebetso ea taolo ea sesole sa 'mele eo Epithalon e e bonts'ang., bonyane ka har'a lisele tsa letlalo.
Tlhahlobo ea lisele tse tšoaroang e bontšitse hore e eketsehile (haholo joalo) SOD-1 le polelo ea NQO1 – ka bobeli li ngotsoe hantle li-antioxidant / li-enzymatic markers. Ho khothaletsa mofuta ona oa sesole sa 'mele’ kapa bonyane ho sireletsa, mosebetsi oa taolo ke ntho eo bo-rasaense ba e boletseng e le phello e ntle.
8.Neuroprotection le Ntlafatso ea Kelello
Matla a ho ithuta e ne e le sepheo sa lithuto tse 'maloa; tšireletso le tokiso ea methapo ea kutlo (litlamorao tsa antioxidant ke karolo e kholo ea ts'ebetso ena, hammoho le li-neurotransmitter tse poteletseng le lintlafatso tse amanang le nako e haufi tsa neurotrophic factor) ke seo Epithalon e khonang ho se fihlela.
Bokhoni bo ntlafetseng ba ho ithuta litšoeneng tse tsofetseng ke phello e tobileng ea lintlha tsohle tse boletsoeng ka holimo.
COA
HPLC
MOF
