Hexapeptide-10, kapa ho feta moo ka molao e bitsoang SIKVAV/Serilesine, ke karolo e nyane ka ho fetisisa e sebetsang e arohaneng hantle le sebaka sa globular sa lamine α1 ketane. Ts'ebetso e phahameng ea bioloji ke tšobotsi e hlalosang peptide ena.
Liphuputso tsa pele li bontšitse ho feta ho khomarela lisele-ho phahamisa le, ho isa tekanyong e kgolo, axonal kgolo-stimulating bokgoni ba ha e bapisoa le lamine e tiileng. Tlhokomeliso e khethehileng le ts'ebetso e latelang ea mefuta e fapaneng integrins le li-receptor tse ling tsa holim'a metsi ke thepa e 'ngoe ea bohlokoa; ho ata ha lisele, karohano, le ho pholoha kaofela ho latela e le liphello tse tobileng.
Ka hare saense ea kelello, matla a phekolo bakeng sa ho lokisa tšenyo e bohareng kapa tsamaiso ea methapo ea kutlo e ngotsoe hantle. Lekala la litlolo le sa tsoa bona botumo ba lona bo eketseha haholo.
Hexapeptide-10, fuoa eona neuromodulatory le bokhoni ba ho lokisa lisele, ke karolo ea bohlokoa ea litlolo le dermatological mahlale.
Moreki o thabile haholo, e tla lateloa ke moqapi oa adipiscing. Joalo ka mohlahisi oa mobu, mesarelo, leha e le letlotlo la thepa, mosamo oa protheine.
Tatelano
H-Ser-Ile-Lys-Val-Ala-Val-OH
Nomoro ea CAS
146439-94-3
Foromo ea limolek'hule
C28H53N7O8
Boima ba Molek'hule
615.77
Lipatlisiso tse amanang le Hexapeptide-10
1.Ho Lokisoa ha Letlalo le Taolo ea Homeostasis
Ho hlomathiseletsoa ho hoholo kapa ho fetola bokaholimo ba lintho tse phelang ka Hexapeptide-10 e lumella ho kenngoa ha karohano ea lisele tsa stem, fibroblast/endothelial ho ata ha lisele le ho falla ka tsela e lebisitsoeng – ka hona ho potlakisa pholiso ea maqeba a letlalo.
Taolo e nepahetseng ea keratinocyte proliferation-differentiation balance ke eona e e khethollang; ho ata ho feteletseng ha epidermal basal layer hoa lekanngoa, ho khothaletsa karohano e hlophisehileng ea stratum corneum.
Matla a sebopeho sa letlalo le botšepehi ka kakaretso lia ntlafatsoa, sebopeho e leng taba ea mantlha. Litsela tsa matšoao a Neural li boetse li fetotsoe, ho fokotsa kutlo ea letlalo ho lintho tse tsoang kantle; letlalo le nang le kutlo ka ho khetheha melemo e tsoang ho tsohle tse ka holimo.
2.Ho laola ho ata ha keratinocyte le karohano ho boloka homeostasis ea letlalo
Hexapeptide-10 e sebetsa ka kotloloho liseleng tsa epidermal, ho leka-lekanya ho ata ha tsona le phapang e latelang.
Ho thibela phapang e sa tloaelehang le karohano e sa laoleheng ka har'a lera la basal, e laola tlhahiso ea liphatsa tsa lefutso tsa liprotheine tse amanang le phapang ea ho qetela. Mathata a ho khetholla lisele ka lebaka la ho tsofala, khatello ea tikoloho, kapa maemo a itseng a letlalo a lokisoa ka katleho.
E felletseng haholoanyane, tšitiso e sebetsang e matla ea 'mele e thehoa; ho eketseha ha hydration ea letlalo ke phello e tobileng, letlalo le boreleli le le hloekisitsoeng ho ba ntlha ea ho qetela ea ts'ebetso ena.
3.Taolo ea Letlalo le Bohloko le ho Pholoha ho amanang le Ho hlohlona / Ho se thabise
Ho sebelisana le li-receptors ho methapo ea kutlo ke mokhoa oa bohlokoa; modulating likanale tsa ion ka hona e laola ho hlasimoloha ha methapo ea kutlo.
Pro-inflammatory factor secretion e thibetsoe, 'me moeli o phahameng oa kutlo o lebisa phokotsong e kholo kapa ho felisoa ha ho chesa, hlaba, ho hlohlona le ho tiisa. Mamello ea nako e telele ea khatello ea tikoloho ka hona e bolokoa boemong bona ba methapo ea kutlo.
4.Ho Khothalletsa Khōlo ea Axonal le Neural Repair
Li-receptor tse khethehileng tsa "neuronal surface" ke sepheo sa Hexapeptide-10.
Sena se etsa hore ho be le li-cascade tsa intracellular (Focal Adhesion Kinase le Src family kinase) e etsang hore ho be le mekhoa e metle ea ho hlahisa liphatsa tsa lefutso ho ea ka kholo le karohano. Cytoskeletal protheine synthesis le ho hlophisoa bocha ho laoloa ka har'a neuron ka boeona.
Boithuto ba biomaterial bo bonts'itse li-axon tse nchafatsang ho latela litloaelo tse hlalositsoeng tsa scaffold, ho theha bocha khokahano le li-tissue tse shebiloeng. Ho lokisoa ha methapo ea methapo le letlalo ke phello e tobileng ea mekhoa ena.
COA
HPLC
MOF
