KPV peptide ke eng：KPV ke peptide ea maiketsetso ea bioactive e nkiloeng ho sekhechana sa C-terminal ultra-short tripeptide se etsahalang ka tlhaho. α-Melanocyte-Stimulating Hormone (α-MSH). Lipatlisiso ka likhechana tse fapaneng tsa α-MSH li entse hore bo-rasaense ba sibolle hore tatellano e khethehileng ea C-terminal KPV. – e nang le li-amino acid tse tharo tsa ho qetela – e lahleheloa ke phello ea eona e khothalletsang melanogenesis; e ntlafatsa haholo thepa ea anti-inflammatory le immunomodulatory, leha ho le joalo, li bolokiloe.
KPV ka boeona e sebetsa ka mekhoa e seng ea ergoline; thibelo ea ts'ebetso le ho ngoloa ho latelang ha lintlha tsa bohlokoa tsa ho ruruha e le mokhoa oa mantlha oa ketso.. Li-cytokine tse ngata tsa pro-inflammatory ka hona li hatelloa ka katleho tlhahisong le ho lokolloa.
Ho feto-fetoha ha lisele tse khethehileng tsa 'mele (li-lymphocyte, macrophages hara tse ding) ke karolo e 'ngoe e kholo ea phello ea eona, ho bopa bocha tikoloho ea 'mele e khahlanong le ho ruruha. Ho lokisoa ha ho ruruha hoa hlohlelletsoa 'me ka kakaretso mosebetsi oa ho thibela ho ruruha o eketseha.
Liteko tsa meriana li bontšitse ntlafatso e hlakileng ho colitis ea liteko; fokotsehile mucosal edema, tshireletso ya tšitiso ea mala tshebetso, le mefuta e fapaneng ea tokiso ea boemo ba lisele / lisele kaofela ke liphetho tse ka lekanyetsoang.
Boima bo tlase ba limolek'hule tsa KPV ke molemo o mong oa bohlokoa, e fana ka bioavailability e ntle ea molomo le bokhoni bo hlokomelehang ba ho monya ha transdermal. Tsamaiso ea molomo e e lumella ho hanela ho senyeha ka ho senya mala li-enzyme le ho fihla maleng tsamaiso ea 'mele ea ho itšireletsa mafung ea mucosal ka kotloloho.
Tatelano
H-Lys-Pro-Val-OH
Nomoro ea CAS
67727-97-3
Foromo ea limolek'hule
C16H30N4O4
Boima ba Molek'hule
342.44
Patlisiso ea KPV Peptide
1.Mosebetsi o khahlanong le ho ruruha
Sena ke bohareng, mosebetsi oa mantlha oa KPV. Ho lebisa tlhokomelo ea mantlha NF-kB ka har'a litsela tsa pontšo ea ho ruruha ha lisele, ho thiba tshebetso/phetisetso ke yona e hlalosang ketso ya yona.
Polelo le mongolo oa li-pro-inflammatory mediators li sitisoa mohloling. Lintho tse khahlanong le ho ruruha li boetse li khothalletsoa.
Ho fetola tikoloho ea ho ruruha ha lisele ke ntlha ea mantlha ea liketso tse peli tsa taolo tsa KPV..
2.Liphello tsa Immunomodulatory
Ts'ebetso ea ho itšireletsa mafung ea KPV e tsoa tšebetsong ea eona e matla ea ho thibela ho ruruha. Ho hatella polelo ea liphatsa tsa lefutso tsa M1 tsa pro-inflammatory, ts'ebetso ena e thusa ho potlakisa polarization ea phenotype ea M2 – mokhoa oa bohlokoa oa taolo ka har'a sesole sa 'mele.
Tsamaiso e tsoelang pele ea KPV ho litoeba tse bontšang likarabo tsa ho ruruha ho fella ka sehlopha sa liteko se bontšang ho ruruha ho fokotsehileng, kapa qeto e felletseng ea eona; mesebetsi ya fisioloji e ikamahanyang haufi le ditaolo tse phetseng hantle.
3.Liphello Tse Khethehileng Tsa Tšireletso Mafung a Ruruhileng a Mala (IBD)
Boleng bo ikhethang ba ts'ebeliso bo bonts'oa ke KPV ka bophelo bo botle ba mala.
Mehlala ea litoeba ea ho ruruha e bontša ntlafatso e hlakileng ea IBD(Boloetse bo Ratang Malapeng) matšoao ka tsamaiso ea molomo. Tšenyo ea lisele tsa mala, edema, khoholeho ea mobu, mme ho kenella ha lisele tsa ho ruruha kaofela ho fokotsehile haholo.
Ho lokisa le ho matlafatsa botšepehi ba thibelo ea mucosal ke e 'ngoe ea liketso tsa mantlha tsa KPV; phokotso ea ho kenella ha mala ho latela. Likokoana-hloko le li-antigen tsa tsona li thibetsoe ho fetela ka har'a mokoallo oa mala, ka hona ho thibela ho sebetsa ho feteletseng ha sesole sa 'mele ka lebaka la sona.
Pholiso ea mucosa ka boeona ke phello e tobileng ea liphello tsena tse sireletsang.
4.Ho Khothalletsa ho Lokisoa le ho Tsosolosa Maqeba
Ka ho hatella ho ruruha, KPV e theha tikoloho e ntlafalitsoeng ea cellular hore tokiso e joalo e etsahale.
Lintho tse khahlanong le ho ruruha le ho lokisa lisele tsa cellular li sebelisoa. Liphuputso li bonts'itse ho lokisoa ka potlako le ho nchafatsoa ha lisele tsa mala le lisele tsa letlalo la epidermal ho lithuto tse alafiloeng ke KPV..
Pholiso ea maqeba, le tsohle tse latelang, ke karolo ea seo KPV e khonang ho se fihlela.
COA
HPLC
MOF
