PTD-DBM ke peptide ea phekolo haholo-holo e sebelisetsoang ho phekola mefuta e sa tšoaneng ea ho lahleheloa ke moriri.
Tatelano ea eona ea amino acid e nkiloe kutloisisong e tebileng ea pathophysiology ea androgenetiki alopecia, mmoho le ho sibolloa le ts'ebeliso e latelang ea li-peptide tse kenang liseleng (CPPs).
Litaelo tse ngata tse ruileng tsa arginine li kenyelelitsoe ka har'a PTD-DBM, ho e fa matla a matla a ho phunyeletsa liseleng.
Khokahano e kopaneng (ka sehokelo sa glycine) ho karolo e hlalositsoeng ea bioactive DBM peptide e fana ka likarolo tse peli tse sebetsang tsa peptide.
The poly-arginine tatellano ho N-terminus e lumella ho kenella ka katleho ha stratum corneum ea letlalo le lisele tse latelang tsa lisele.; phano e nepahetseng ya phahlo e sebetsang ho lisele tsa dermal papilla (le li-stem cell niches tse amanang le tsona) finyelloa.
Ho sibolloa le ho qaptjoa ha PTD-DBM ho bontša phetoho e kholo kalafong ea tahlehelo ea moriri – ho falla ho tsoa ho tsamaiso kapa litlamorao tse bonolo tsa vasodilatory, ho lokisa microenvironmental le regenerative ea follicle ea moriri ka boeona.
Tatelano
Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Gly-Arg-Lys-Thr-Gly-His-Gln-Ile-Cys-Lys-Phe-Arg-Lys-Cys
Nomoro ea CAS
1609454-11-6
Foromo ea limolek'hule
Setšoantšo sa C124H225N61O28S2
Boima ba Molek'hule
3082.683
Patlisiso e Amanang le Peptide ea PTD-DBM
Karolo ea carboxyl-terminal DBM e sebetsa e le leraba le itseng la molek'hule, ho hapa limolek'hule tsa BMP tse feteletseng – intracellularly le extracellularly – ho ba nyenyefatsa.
Ka tsela eo, matshwao a thibelang ho hola ka ho otloloha a ntse a thibelwa.
DBM e imolla tšitiso ena, ho lelefatsa mokhahlelo oa anagen (kgolo) le ho thibela phetoho ea catagen/telogen pele ho nako.
Liphello tse matla tse khahlanong le ho lahleheloa ke moriri li fella: motenya, ho hlahisoa moriri o tsitsitseng haholoanyane.
Ea bobeli, ho tsosolosoa ha lisele tsa stem tsa moriri o robetseng ho bonoa, ka ts'ehetso ea ho ata ha bona le ho aroloa ho li-progenitors tse ncha tsa moriri tse tšehetsoeng.
Ka ho toba, Li-BMP ke matšoao a mantlha a thibelang kholo ea moriri; PTD-DBM e tlamella le ho thibela ts'ebetso ea matšoao ana, 'me kahoo liphello tsohle tse boletsoeng ka holimo li latela e le phello e tobileng ea ketso ea eona.
Nakong ea potoloho e tloaelehileng ea ho hōla ha moriri, anagen (mohato oa kholo) e lateloa ke catagen (mokgoa wa ho kgutlela morao).
Liprotheine tsa Bone morphogenetic (Li-BMPs) pontšo e phetha karolo ea bohlokoa ho khutsufatsa mohato ona oa anagen; ho kena telogen pele ho nako, mokhahlelo oa 'nete oa phomolo, ke sephetho se tobileng.
Hanyane, kgutshoanyane, moriri o nang le mebala e fokolang o latela lipotoloho tse latelang.
PTD-DBM e sebetsa ho thibela tsela ena e khethehileng ea lipontšo.
Ho lelefatsa mohato o sebetsang ke e 'ngoe ea mekhoa ea eona ea mantlha ea ketso.
Tlhahiso e tsoelang pele ea moriri o motenya ho feta o phetseng hantle o ka khoneha; ho emisa mokhoa oa pathological oa ho lahleheloa ke moriri ka boeona ke ntlha ea ho qetela eo motsoako o ikemiselitseng ho o finyella.
Ka hona, boima ba moriri bo bolokiloe.
COA
HPLC
MOF
