Vilon

Villa

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Vilon

Villa

Vilon e tsejoa e na le phello ho sebopeho sa lymphocyte le parthenogenetic heterochromatin.

 

 

SKU: 198902 Sehlopha:
Arolelana lerato la hau

Ka bolelele ba li-amino acid tse peli feela, Vilon ke peptide e khuts'oane ka ho fetisisa e tsejoang e na le ts'ebetso ea likokoana-hloko. Lipatlisiso li bontša hore Vilon e na le liphello tse matla tse thibelang botsofali le hore ke taolo e matla ea ts'ebetso ea 'mele ea ho itšireletsa mafung. Hape ho na le bopaki bo botle ba hore Vilon e thusa ho laola tsamaiso ea methapo ea mali le ho khothalletsa hemostasis. Vilon e bontšitsoe ho fokotsa sekhahla le kholo ea lihlahala tse itlhahelang feela, leha e le karolo ea eona e le mothusi kalafong ea mofets'e (kgahlanong le thibelo) e 'nile ea belaelloa. Ka kakaretso, Vilon e na le babuelli ba 'maloa ba hloahloa, joalo ka Dr. Vladimir Anisimov, ba ikutloang hore peptide ke ntho e sebetsang e sireletsang bophelo.

Tatelano

Lysylglutamate, normophthal, Asiti ea Lysglutamic

Nomoro ea CAS

45234-02-4

Foromo ea limolek'hule

C176H277N57O55S7

Boima ba Molek'hule

257.30

Lipatlisiso tse amanang le Vilon

Lipatlisiso tse tsoang Russia li bontša hore Vilon ke molaoli ea matla oa sebopeho sa chromatin. Phuputso e 'ngoe e fumane hore Vilon:

• etsa hore chromatin e lokolloe,

• e kenya tshebetsong tshebetsong ya maiketsetso ka ho kenya tshebetsong hape diphatsa tsa lefutso tsa ribosomal ho chromatin e sa phutholohang,

• ho lokolla liphatsa tsa lefutso tse hatelitsoeng, le

• ha e bake decondensation ea pericentromeric structural chromatin[1].e etsa hore chromatin e hlahisoe,

Liphetho tse felletseng tsa liphetoho tseo Vilon e li bakang ho DNA ke ts'ebetso ea liphatsa tsa lefutso tse seng li khutsisitsoe.. Ka kakaretso, chromatin e fumanoa leha e le leqeba (heterochromatin) kapa e senyehile (Euchromatin) linaha. Heterochromatin e ke ke ea fumaneha ka lisebelisoa tse fetolang liphatsa tsa lefutso hore e be liprotheine, kahoo likarolo tse sebetsang tsa sele.. Liphatsa tsa lefutso libakeng tsena tsa DNA ha li fumanehe bakeng sa tlhahiso ea liprotheine.

Ka kakaretso, chromatin e thusa ho laola hore na ke liphatsa tsa lefutso life tse fumanehang bakeng sa ho ngoloa, kahoo ke tsela e 'ngoe eo lisele tse fapaneng li ka bang le mesebetsi e fapaneng kapa hore lisele tse tšoanang li ka ba le mesebetsi e fapaneng ka nako.. Ka bomalimabe, chromatin condensation le eona ke ntho e hlahang ka lebaka la botsofali le botsofali 'me bonyane ke lebaka le le leng leo ka lona lisele le lisele tsa rona li lahleheloang ke mosebetsi ha re ntse re tsofala..

E ts'oana le ts'ebetso ea eona ho li-lymphocyte, Vilon e bontšitsoe ho kenya tšebetsong pontšo ea interluekin-2 liseleng tsa spleen[3]. Interleukin-2 e bohlokoa ho hokahanya karabelo ea 'mele ea ho itšireletsa mafung ho tšoaetso ea likokoana-hloko' me e thusa ho thibela ts'ebetso ea autoimmune.. Ka ho kenya li-lymphocyte le splenocyte ha u ntse u matlafatsa tšireletso ea tlhaho khahlanong le liketso tsa autoimmune, Vilon e khutlisetsa sesole sa 'mele boemong bo sebetsang haholoanyane 'me e ka ba ea thusa ho nts'etsapele liphekolo tsa mafu a autoimmune.

Ho eketsa bokhoni ba eona ba ho thibela liphetoho tsa autoimmune ke karolo ea Vilon ho thymus. Lipatlisiso litsong tsa thymus li bontša hore Vilon e eketsa ho ata ha CD5 T-cell. CD5 ke letšoao la lisele tsa T-helper tse hōlileng tsebong hammoho le lisele tsa T-cell tsa cytotoxic. Ea pele e thusa ho laola sesole sa 'mele le ho thibela liketso tsa autoimmune, ha ea morao e le e 'ngoe ea lisele tse matla ka ho fetisisa tse thibelang likokoana-hloko 'meleng[4].

Hoa thahasellisa, Vilon e bonahala e tsosolosa mesebetsi ea 'mele ea ho itšireletsa mafung ka liphatsa tsa lefutso tse khutsisitsoeng ke liphetoho tsa chromatin. Ha e bonahale e kenya tšebetsong liphatsa tsa lefutso tseo ka tlhaho li neng li ka khutsa liseleng tseo e li amang. Ka mantsoe a mang, Vilon ha e fetole li-lymphocyte ho li-neurone ka ho kenya liphatsa tsa lefutso tseo ka tloaelo li neng li ke ke tsa sebetsa li-lymphocyte tse phetseng hantle.. Ho e-na le hoo, peptide e bonahala e matlafatsa ts'ebetso ea sesole sa 'mele ha ka nako e ts'oanang e thusa ho thibela ts'ebetso ea autoimmune.

Vilon le Kankere

Joalokaha ho boletsoe ka holimo, Vilon e thusa ho fokotsa sekhahla sa mofetše mefuteng ea litoeba, eo bonyane e leng tsela e le 'ngoe eo ka eona e lelefatsang bophelo bo tloaelehileng. Lipatlisiso tse ling li bontša hore Vilon ha e thibele feela lihlahala ho thehoa, empa e sitisa kgolo ya tsona ka mora hore di be teng[5]. Sena se fana ka maikutlo a hore Vilon e kanna ea ba chemotherapeutic e sebetsang ka bo eona, hammoho le tlatsetso e ka bang teng ho kalafo e teng ea mofetše. Nakong e tlang, Vilon e ka ba tlatsetso e tloaelehileng ho tsohle ho tloha chemotherapy ho ea kalafo ea radiation le opereishene.

Bonyane thuto e le 'ngoe, ho tsoa Russia, e hanana le taba ea hore Vilon e ka ba mothusi oa chemotherapy. Mesebetsi e bontša hore motsoako oa Vilon le platinum-based chemotherapeutic agents o na le bothata ho e-na le ho lumellana.[6]. Ka bomalimabe, phuputso ena e sebelisitse mofuta o le mong feela oa chemotherapy 'me e ne e lekanyelitsoe ka bophara, kahoo liphetho li ke ke tsa akaretsa. Ho sa ntse ho tla bonahala hore na Vilon e sebetsa hantle feela khahlanong le mofets'e ka bo eona kapa haeba peptide e ka eketsoa ho mefuta e meng ea kalafo ho matlafatsa sephetho..

Vilon le Botsofali

Patlisiso ho litoeba e bonts'a hore tsamaiso e tlase ea Vilon e eketsa boikoetliso le mamello ha e ntse e thusa ho fokotsa kotsi ea mofets'e.. Liphello tsena tse peli li entse hore ho be le nako e telele ea bophelo ho litoeba tse phekoloang, e fana ka maikutlo a hore Vilon e kanna ea ba peptide e molaong e thibelang botsofali[7]. Sena se khothatsa haholo hobane ha sea hlahisa litlamorao tse mpe ho litoeba kamora tsamaiso ea nako e telele.

Hoa thahasellisa, lipatlisiso li bontša hore Vilon ea pejana e tsamaisoa, litlamorao tsa eona li bonahala li le kholoanyane. Ka mantsoe a mang, Ho fana ka Vilon ho litoeba tse nyane ho eketsa nako ea bophelo ho feta ha Vilon e sa laoloe ho fihlela litoeba li se li tsofetse haholo.. Phello e tšoanang e ile ea bonoa lithutong tsa pele tse shebaneng le li-extracts tse tala tsa thymic le pineal tse fuoeng litoeba ho fokotsa botsofali.[8]. Khopolo-taba ke hore Vilon le li-peptide tse tšoanang, ha e fanoa ka mora nako ea bophelo, e ka fetola senescence liseleng tse teng empa ho hlakile hore e ke ke ea etsa letho bakeng sa lisele tse seng li felisitsoe ka apoptosis.. Ka ho fana ka Vilon 20mg qalong ea bophelo, lisele li fumana ts'ireletso e kholo ka ho fetisisa 'me kahoo phetoho ea fokotseha. Phello ke hore lisele tse ngata li lula li phetse hantle ka nako e telele, ho liehisa tlhoko ea ho li nkela sebaka le ho boloka mela e lekanyelitsoeng ea lisele tsa stem.

Litlamorao tse khahlanong le botsofali tsa Vilon li bonahala li atoloha ho ts'ebetso ea GI hape, moo peptide e bontšitsoeng ho ntlafatsa tšebetso ea li-enzyme tse itseng lipampitšaneng tsa Gi tsa litoeba tsa khale. Peptide e boetse e bonahala e ntlafatsa ts'ebetso ea thibelo, ka hona ho fokotsa sekhahla sa ho dutla mala, ho matlafatsa ho hanyetsa mafu, le ho ntlafatsa bophelo bo botle ka kakaretso ba pampitšana ea GI ho litoeba tsa khale[9]. Lipatlisiso li bontša hore Vilon ka tsela eo e thusa ho ntlafatsa ho kenngoa ha tsoekere le glycine ka maleng a manyenyane a likhoto tsa khale.[10]. Likarolo tsena tsa Vilon li ka thusa ho boloka ho ntšoa ha limatlafatsi ka lilemo, ka hona ho ntlafatsa bophelo bo botle ka kakaretso le mohlomong ho ntlafatsa bophelo bo bolelele.

Dr. Vladimir N. Anisimov, ea ntseng a etsa lipatlisiso tsa botsofali le nts'etsopele ea mofets'e ho tloha ka bo-1970, e bontša hore thymus ke e 'ngoe ea litšoelesa tse peli (e 'ngoe ke tšoelesa ea phaene) e phethang karolo ea bohlokoa ho laola botsofali. The thymus e phetse hantle, bophelo bo botle ba rona re le batho ka bomong. Ehlile, Vilon ke thymic peptide mme e ama lisele, joalo ka li-lymphocyte, tse hlahisoang ka har'a le ho hola ka har'a thymus. Dr. Anisimov ke 'muelli ea matla oa ho sebelisa li-peptide bioregulators ho thibela mofetše.[11]. Ke mosebetsi-'moho ea haufi oa Dr. Vladimir Khavinson.

Vilon ka Pelong le Liphio

Phello ea Vilon ho vasculature ha e so ithutoe hantle, empa ho na le mosebetsi o mong oa ho fana ka maikutlo a hore e ka ba le phello e molemo. Lipatlisiso ho litoeba li bontša hore Vilon e fetola polelo ea ho feta 36 liphatsa tsa lefutso tse fapaneng ka hare ho pelo. Ha e kopantsoe le Epithalon, palo ena e tlolela ho 144 liphatsa tsa lefutso[12]. Liphuputso tsena li fana ka maikutlo a hore, bonyane, Vilon e na le bokhoni ba ho fetola mekhoa ea liphatsa tsa lefutso tsamaisong ea pelo, 'nete e ka ntlafatsang ts'ebetso ea hemodynamic.

Haele hantle, lipatlisiso ka liphio, litho tse ngata tsa methapo, e bonts'a hore Vilon e fokotsa likhakanyo tsa phetoho ea kholo ea beta(1) 'me kahoo ho phunyeletsa ha li-microvessels. Sephetho sa kakaretso ke ho ntlafala ha hemostasis nakong ea ho hloleha ha liphio, ho fana ka maikutlo a hore Vilon e etsa joalo, haele hantle, e na le phello e molemo tsamaisong ea vascular[13].

Ho feta moo, Lipatlisiso ho bakuli ba tsofetseng ba nang le lefu la tsoekere li bonts'a hore Vilon e ka thusa ho ntlafatsa coagulation ka ho eketsa maemo a anticoagulants ea tlhaho ea antithrombin III le protheine ea C ha e ntse e susumetsa fibrinolysis.[14]. Phello ke ho fokotseha ho fokolang ha mali ho baahi ba nang le bothata ba ho koala le liphello tse tebileng tse latelang. Sena se tsoela pele ho tšehetsa khopolo ea hore Vilon e phetha karolo ea bohlokoa ho laola tsamaiso ea methapo ea mali.

COA

HPLC

MOF

[1] T. Lezhava le al., "Bioregulator Vilon-induced reactivation ea chromatin ho li-lymphocyte tse hlahisitsoeng ho tsoa ho batho ba khale.,” Biogerontology, vol. 5, che. 2, maq. 73–79, 2004, doi: 10.1023/B:BGEN.0000025070.90330.7f.

[2] T. Lezhava, J. Monaselidze, T. Ho nyamela ha ka, N. Dvalishvili, le T. Buadze, "Li-bioregulator tsa peptide tse thibelang botsofali li etsa hore chromatin e tsosolosoe,” Segeorgia Med. Litaba, che. 133, maq. 111–115, Mmesa. 2006.

[3] T. B. Kazakova le al., "In vitro phello ea li-peptide tse khutšoane ho polelo ea liphatsa tsa lefutso tsa interleukin-2 ho splenocytes,” Poho. Exp. Biol. Ka., vol. 133, che. 6, maq. 614–616, Jun. 2002, doi: 10.1023/a:1020210615148.

[4] N. N. Sevostianova le al., "Litlamorao tsa immunomodulating tsa Vilon le analogue ea eona moetlong oa lisele tsa thymus tsa batho le liphoofolo,” Poho. Exp. Biol. Ka., vol. 154, che. 4, maq. 562-565, Hlakola. 2013, doi: 10.1007/s10517-013-2000-0.

[5] V. K. Khavinson le V. N. Anisimov, "Vilon ea maiketsetso ea dipeptide (L-Lys-L-Glu) e thibela ho hōla ha lihlahala tse itlelang feela 'me e eketsa nako ea bophelo ba litoeba,” Ho fihlela. Biol. Sci. Proc. Akad. Sci. Biol ea USSR. Sci. Lequloana., vol. 372, maq. 261-263, Jun. 2000.

[6] O. P. Barykin, V. V. Yuzhakov, N. I. Chalisova, I. M. Kvetnoĭ, le S. S. Konovalov, “[Tšusumetso e kopaneng ea vilon le cyclophosphane ho li-tumor transplants le li-lymphoid tissue explants ho litoeba le likhoto tsa lilemo tse fapaneng.],” Adv. Gerontol. Uspekhi Gerontol., vol. 12, maq. 128–131, 2003.

[7] V. K. Khavinson le al., "Phello ea vilon lilemong tsa tlhaho le nako ea bophelo ho litoeba,” Poho. Exp. Biol. Ka., vol. 130, che. 7, maq. 687-690, Jul. 2000, doi: 10.1007/BF02682106.

[8] V. N. Anisimov, A. S. Loktionov, V. K. Khavinson, le V. G. Morozov, "Phello ea lintlha tse tlase tsa boima ba limolek'hule tsa thymus le pineal gland ka nako ea bophelo le nts'etsopele ea hlahala ho litoeba tse tšehali tsa lilemo tse fapaneng.,” Mech. Botsofali Dev., vol. 49, che. 3, maq. 245–257, Sep. 1989, doi: 10.1016/0047-6374(89)90075-4.

[9] V. K. Khavinson, N. M. Timofeeva, V. V. ea Mali, L. A. Gordova, le A. A. Nikitina, "Phello ea vilon le epithalon mosebetsing oa li-enzyme tse ka har'a epithelial le subepithelial ka maleng a manyane a likhoto tsa khale.,” Poho. Exp. Biol. Ka., vol. 134, che. 6, Art. che. 6, Tšitoe. 2002.

[10 ]V. K. Khavinson, V. V. Egorova, N. M. Timofeeva, V. V. ea Mali, L. A. Gordova, le L. V. Diaduma, "Phello ea Vilon le Epithalon ho ho monya ha tsoekere le glycine libakeng tse fapaneng tsa mala a manyane ho likhoto tse tsofetseng.,” Poho. Exp. Biol. Ka., vol. 133, che. 5, maq. 494-496, Mots'eanong 2002, doi: 10.1023/a:1019878224754.

[11] V. N. Anisimov le V. K. Khavinson, “[Tšebeliso ea li-bioregulator tsa peptide bakeng sa thibelo ea mofetše: liphetho tsa 35 lilemo tsa boiphihlelo ba lipatlisiso le maikutlo],” Vopr. Oncol., vol. 55, che. 3, maq. 291-304, 2009.

[12] S. V. Anisimov, K. R. Bokheler, V. K. Khavinson, le V. N. Anisimov, "Lithuto tsa litlamorao tsa Vilon le Epithalon mabapi le polelo ea liphatsa tsa lefutso pelong ea toeba ho sebelisa theknoloji ea DNA-microarray.,” Poho. Exp. Biol. Ka., vol. 133, che. 3, maq. 293–299, Mar. 2002, doi: 10.1023/a:1015859322630.

[13] N. A. Gavrisheva, V. V. ea Mali, T. P. Ses, K. L. Kozlov, A. V. Panchenko, le A. Y. Titkov, "Phello ea peptide Vilon ho litaba tsa phetoho ea kholo-beta le ho kenella ha li-microvessels nakong ea liteko tse sa foleng tsa renal.,” Poho. Exp. Biol. Ka., vol. 139, che. 1, maq. 24–26, Jan. 2005, doi: 10.1007/s10517-005-0202-9.

[14] B. I. Hoznik, N. V. Isakova, N. N. Kliuchereva, N. V. Maleeva, le ke. S. Pinelis, “[Phello ea vilon ho boemo ba ho itšireletsa mafung le coagulation hemostasis ho bakuli ba lilemo tse fapaneng ba nang le lefu la tsoekere mellitus.],” Adv. Gerontol. Uspekhi Gerontol., vol. 20, che. 2, maq. 106–115, 2007.

Lintlha tsa Qotso ea Sengoloa/Lingoliloeng

Sepheo sa ho qotsa sengoloa sa rasaense le moprofesa ke ho amohela, hlokomela le ho thoholetsa mosebetsi o felletseng oa ntlafatso o entsoeng ho etsa lipatlisiso tsa peptide. Rasaense ha a tšehetse kapa ho buella ho reka ka tsela leha e le efe, thekiso kapa tshebediso ya sehlahiswa sena ka lebaka lefe kapa lefe, mme MOL Changes ha e na kamano kapa kamano, e boletsoeng kapa ka tsela e fapaneng, le ramahlale.

temoso

Lihlahisoa tsena li etselitsoe merero ea mahlale feela bakeng sa lipatlisiso tsa in vitro mme ha lia lokela ho sebelisoa ho batho, liteko tsa phoofolo kapa tse sa lokang, lipatlisiso tsa in vitro (Selatine: ka khalase) e etsoa ka in vitro. Lihlahisoa tsena ha se lithethefatsi 'me ha li amoheloe ke Tsamaiso ea Lijo le Lithethefatsi naheng efe kapa efe bakeng sa thibelo, kalafo kapa pheko ya boemo bofe kapa bofe ba bongaka, lefu kapa bokudi. Ho kenngoa ha sehlahisoa sena ho batho kapa liphoofolo ka mokhoa ofe kapa ofe ho thibetsoe ka thata ke molao.

tlhaloso

5 mg

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