Acetyl Dipeptide-1 cetyl ester

1.What Is Acetyl Dipeptide-1 cetyl ester

Acetyl Dipeptide-1 Cetyl Ester is the specifically designed synthetic peptide for skincare products; the primary core function being some form of skin soothing, irritation and near all types of inflammation reduction.

Promotion of the proopiomelanocortin (POMC) gene expression is its key researched action. The post-translational processing of POMC leads to multiple bioactive peptides; melanin synthesis related MSHs and adrenocorticotropic hormone (ACTH) being two prime examples, with β-endorphin (opoid active) also produced.

α-MSH binds to melanocyte melanocortin receptors, inducing at least partial melanin synthesis, but the previously mentioned regulation of NF-κB activity allows for a direct anti-inflammatory effect. Reducing Calcitonin gene-related peptide (CGRP) release is the final, yet important, neuro-soothing link – CGRP itself activates TRPV1 receptors.

All of the above biological effects are what make acetyl dipeptide-1 cetyl ester so valuable to the modern cosmetic industry. Neuro-soothing, barrier and anti-aging effects are all interrelatedly achieved through this ingredient’s mechanisms of action.

2.Research Findings On Acetyl Dipeptide-1 cetyl ester

1)Neuro-soothing and Anti-inflammatory Effects

In one clinical study, 21 volunteers experienced significantly reduced temperature perception after applying a cream containing 3% acetyl dipeptide-1 cetyl ester. A separate double-blind study saw 18 of these volunteers report higher overall comfort levels in hands subjected to sandpaper abrasion; the same cream was the intervention.

This suggests acetyl dipeptide-1 cetearyl ester alleviates at least some discomforts specific to hypersensitive skin, sensory nervous system overactivity being a primary concern.

In vitro studies confirm the ingredient itself reduces prostaglandin E2 (PGE2) secretion – neurogenic inflammation being directly implicated in sensitive skin. Simultaneously, inhibition of the nuclear factor κB (NF-κB) signaling pathway is observed.

NF-κB is a pivotal transcription factor; multiple pro-inflammatory cytokines (Interleukin-1 beta /IL-1β, Tumor necrosis factor /TNF,Interleukin 6 (IL-6) among others) are regulated through it, and its suppression effectively curbs inflammatory responses.

2)Strengthening the Skin Barrier

Research demonstrates the upregulation of various barrier related genes by this active, aquaporin 3 (AQP3), filaggrin (FLG), caspase 14 and keratin 10 being among the more notable improvements seen.

3)Anti-Aging Properties

Beyond soothing and simple repair, multi-targeted anti-aging is the third and perhaps most desirable effect.

In vitro at least, antioxidant and anti-glycation properties have been demonstrated; free radical and AGE damage to skin cells are constant contributors to aging.

UV photoaging specifically can be mitigated by the previously mentioned autophagy (cellular ‘cleaning’) mechanisms, thereby helping maintain overall skin health and structure.

3.Conclusion

Acetyl Dipeptide-1 Cetearyl Ester is a well thought out, modern skincare active with multiple defined and emerging mechanisms of action to solve common, yet near-constant, modern skin concerns.