Dihexa

Research Of Dihexa Peptide

1.Therapeutic Potential and Mechanisms of Action

Improving learning and memory abilities is one of the more directly observable positive effects.

Neuronal damage from multiple factors – oxidative stress, β-amyloid (Aβ) related toxicity, mitochondrial dysfunction – can be inhibited by Dihexa.

Theoretical applications for treating a wide range of degenerative neurological diseases (Alzheimer’s, Parkinson’s, Huntington’s being prime examples) follow from this line of research.

Oligodendrocyte precursor cell differentiation, myelin related regeneration, cerebral blood flow/energy supply improvements and to some degree anti-tumour effects are all supported by current evidence.

Great potential exists for Dihexa as a therapeutic agent.

2.Enhancing Learning and Memory

The HGF/CMet system is a key factor in promoting hippocampal development.

In a maze experiment, the Dihexa group demonstrated stronger learning ability; finding hidden platforms, they did so in significantly shorter times than the control group.

The HGF-Tg group itself showed both higher accuracy and enhanced learning persistence.

Compared to the wild-type control, increased HGF expression led to a clear rise in specific hippocampal receptor cells – enhancing learning and memory being one of the more direct positive effects observed.

3.Promoting Synapsis and Dendrite Formation

As a hepatocyte growth factor (HGF)/c-Met receptor agonist, Dihexa activates various signaling pathways (PI3K/Akt being primary, MAPK/ERK secondary), directly facilitating new synapse and to a large extent dendrite formation within neurons.

Dendrite loss is a primary direct cause of all forms of persistent memory decline; learning impairment follows closely behind.

Animal experiments point towards Dihexa having a true therapeutic potential for Alzheimer’s specific diseases.

4.Neuroprotection and Anti-apoptosis

Neurodegenerative diseases progress through multiple pathways – oxidative stress, various forms of mitochondrial dysfunction, and the end result of abnormal protein aggregation leading to neuronal apoptosis.

Dihexa, by stimulating the aforementioned HGF system, effectively interrupts this process; inhibiting (or delaying) the full transmission of apoptotic signals is a crucial part of its neuroprotective action.

5.Promoting myelin regeneration

Myelin is that fatty sheath wrapping the axon of a neuron, accurate and rapid nerve signal transmission depending on it.

Myelin deficiency diseases lead to all sorts of neurological dysfunctions.

Oligodendrocyte precursor cells (and to a point, all neural cells) can be stimulated to promote regeneration of myelin, and Dihexa has a clear and positive effect on the nervous system as a whole.