Dipeptide-2

Research Of Dipeptide-2

Within cosmetic science, Dipeptide-2 is classified as a bioactive peptide with anti-aging potential. Anti-aging skincare has pushed bioactive peptides to the forefront of modern development; small molecular weight, strong (to some extent) targeting capabilities, and relatively good skin permeability all contribute to their popularity. The core bioactivity of dipeptide-2 itself comes from the angiotensin-converting enzyme (ACE) inhibiting property. This forms the near perfect theoretical basis for any cosmetic efficacy it may show, circulation related skin concerns being one of the more direct applications.

Angiotensin-Converting Enzyme (ACE) is a key zinc metallopeptidase; catalyzing the conversion of Angiotensin I into the potent vasoconstrictor Angiotensin II (the renin-angiotensin system being responsible for this process). Angiotensin II as mentioned, causes vasoconstriction, elevated blood pressure, potential fluid retention.

A 2015 study successfully isolated dipeptide-2 from a deep sea fish protein hydrolysate, confirming its ACE inhibitory capabilities – IC50 values were reported, low enough to indicate strong in vitro activity. Clear in vitro proof of this specific ACE inhibition exists.

Confirming the above ACE related activity, the same study also pointed to its antioxidant properties. Oxidative stress is a primary extrinsic form of skin aging; excessive reactive oxygen species damage all cellular components (DNA, proteins, lipids) and activate degradative enzymes of the extracellular matrix. Val-Trp, at least in part, protects the skin cell from this type of damage – free radical type anti-aging effects are a valuable complementary mechanism to its other (and well documented) benefits.

By competitively inhibiting ACE activity, Dipepetide-2 reduces the production of angiotensin II. Vasoconstriction and subsequent local edema are directly alleviated by this reduction.

This mechanism is of particular importance in skincare; ACE inhibition specifically lowers capillary permeability, preventing certain forms of fluid accumulation. Improved lymphatic drainage is a key outcome of this process, with periorbital puffiness and various types of hyperpigmentation being notably reduced. Enhanced microcirculation itself brings about better oxygen and more general nutrient delivery to skin tissues – cellular health and near constant vitality being the end results.

Claiming that dipeptide-2 (in an eye care context) can ‘eliminate eye bags, dark circles, and related edema’ is a well-founded usage of this line of reasoning.

Dipeptide-2 is a very common ingredient within premium anti-aging skincare, eye creams being the prime example. Periorbital edema and at least some aspects of dark circles are reliably reduced by it. Strengthening the skin barrier and all round hydration are additional, positively reported benefits.

Clinical studies support all the above mentioned improvements; firmness and radiance are quantifiable end points of treatment efficacy.