P21 peptide yana da zaɓi sosai roba peptide fili tare da babban shamakin kwakwalwa permeability. An samo daga bincike mai zurfi akan Ciliary neurotrophic factor (CNTF), CNTF kanta abu ne na halitta cytokine cikin neurons; multifunctional neurotrophic factor.
Masana kimiyya sun gano, duk da haka, cewa tsarin CNTF na halitta yana da rikitarwa; wahalar hayewa shingen jini-kwakwalwa, immunogenicity kasada, da ɗan gajeren rabin rayuwa duk suna gabatar da ƙalubale masu mahimmanci don bincike na asibiti.
Binciken tsagaitawa da gwaje-gwajen da suka biyo baya sun haifar da gano ainihin guntu, Ac-DGGL-NH₂. Nazarin in vitro ya nuna wannan guntu yana riƙe da kyakkyawan aiki na ainihin aikin neurotrophic, amma duk ƙarin damar warkewa ya kasance kuma ya rage.
Abubuwan da ke hana ruwa gudu su ne rashin daidaituwar shingen jini-kwakwalwa da kuma kusa da saurin lalacewa ta hanyar proteases na plasma.; ƙasa da ƙasa bioavailability a vivo shine sakamakon ƙarshe.
Don magance waɗannan batutuwan tsarin tricyclic lipophilic sosai – adamantane motsi – aka gabatar. Wannan gyare-gyaren ya sami nasarar haɓaka iyawar P21, cikas cikas samar da aƙalla kariya ta N-terminal peptide daga maganin rigakafi kai hari.
Inganta kwanciyar hankali na rayuwa kuma rabin rayuwa mai tsawo ya biyo baya a sakamakon kai tsaye.
Gabaɗaya, Ana samun nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan jijiya da halayen halayen ta hanyar ƙirar P21.
Jeri
Ac–asp-gly-gly-leu-adamantane-NH2
Lambar CAS
/
Tsarin kwayoyin halitta
Saukewa: C27H41N5O9
Nauyin Kwayoyin Halitta
579.65
P21 Bincike mai alaƙa da Peptide
1.Ayyukan Halittu na CNTF
Bayan inganta rayuwar neuron mota, stimulating daban-daban siffofin neurotransmitter kira, haifar da ci gaban neuronal axon, da kuma kare biyu neurons da su goyon bayan Kwayoyin daga excitotoxicity da wasu nau'ikan lalacewar kumburi, CNTF yana kunna takamaiman hanyoyin sigina a cikin hypothalamus – karuwar satiety kasancewa ɗaya daga cikin mafi ingantaccen tasiri.
2.Ingancin Clinical da Abubuwan Kariyar Neuro
Gwaje-gwaje na asibiti sun nuna P21 don samun ingantaccen aikin harhada magunguna idan aka kwatanta da CNTF. Hippocampal neurogenesis, duk nau'ikan synaptic filastik, iyawar koyo da ire-iren matsalolin fahimi duk suna da tasiri sosai.
Tasirin Neuroprotective (ischemia / reperfusion, neuroinflammation kuma oxidative danniya) ana kuma gani, da kuma kayyade, da P21.
3.Haɓaka Neurogenesis da haɓaka Plasticity Synaptic
P21 yana haifar da ingantaccen microenvironment don yaduwa, bambanta, da kuma tsira daga sabbin ƙwayoyin cuta.
Modulation na takamaiman hanyoyin sigina – YADDA/ STAT zama firamare, tare da wasu shaidu na MAPK/ERK – ke da alhakin wannan tasirin.
Ƙarfafa filastik synaptic ta hanyar sauye-sauye masu sauƙi a cikin 'ƙarfi’ na hanyoyin haɗin jijiyoyi wata hanya ce mai mahimmanci; Ƙarfin ilmantarwa yana da alaƙa kai tsaye da wannan tsari.
Samfuran dabbobi suna nuna mahimman abubuwan haɓakawa a ciki Dogon ƙarfin ƙarfi (LTP) a cikin sel hippocampal, Koyon dogaro da hippocampus da haɓaka nau'ikan ƙwaƙwalwa daban-daban a sakamakon haka.
Mahimman tanadin fahimi da duk filastik zagaye na kwakwalwa don haka P21 ke haɓakawa.
4.Ayyukan Neuroprotective
Haɓaka hanyoyin sadarwar kariyar antioxidant na cikin salula yana da tasiri sosai a rubuce.
Tabbatar da aikin mitochondrial, hana wasu hanyoyin apoptotic, da kuma dannewa (wuce gona da iri) neuroinflammation duk suna ba da gudummawa ga yanayin karewa.
Mutuwar jijiyoyi da aka kwaikwayi – hypoxia - ischemia, ko kuma kwanan nan cutar Alzheimer ta kwaikwayi guba – P21 na iya hana shi yadda ya kamata.
Tsayar da aƙalla ɓangaren ƙimar ƙwayoyin jijiyoyi shine ƙarshen ƙarshen wannan layin na kariya; Ana bincika sabbin hanyoyin warkewa don cututtukan cututtukan neurodegenerative ta hanyarsa.
5.Ka'idar Metabolism Energy da Ciwon Ciki
Nazarin asibiti na farko na CNTF ya bayyana tasirin asarar nauyi.
P21 yana riƙe da ainihin guntun da ke da alhakin hakan. Gwaje-gwaje na asibiti sun tabbatar da dacewar tasirin.
Hanyar leptin-STAT3 (hypothalamic) shine abin da ake mayar da hankali a kai a yanzu; ana ƙara satiety sigina.
Rage nauyi daga P21 yana da tasiri kuma, mahimmanci, kiyaye tsoka.
Insulin hankali kuma yana inganta, tura P21 gaba zuwa cikin ingantaccen magani mai mahimmanci don kiba da haɓakar neurodegeneration.
COA
HPLC
MS
