Pentapeptide-18 (sunan kasuwanci Leuphasyl®) wani roba ne gyara enkephalin analog wanda ke ɗaure zuwa masu karɓar enkephalin akan saman ƙwayoyin jijiya.
Kamar yadda a neuroactive peptide, yana nuna babban alkawari a fagen rigakafin tsufa ga fata ta hanyar kwaikwayon aikin endogenous enkephalins.
Pentapeptide-18 yana aiki a cikin irin wannan hanya zuwa toxin botulinum kuma an nuna shi yana da nasara wajen sassaukar layi mai kyau da wrinkles., hydrating, ƙarfafawa da inganta ingancin fata.
Jeri
Tyr-D-Ala-Gly-Phe-Leu-OH
Lambar CAS
64963-01-5
Tsarin kwayoyin halitta
Saukewa: C29H39N5O7
Nauyin Kwayoyin Halitta
569.65
Pentapeptide-18 Bincike mai alaƙa
1.Gabatarwa zuwa Enkephalins da Tsarin Tsara
Enkephalins ne opioid peptides cewa aiki kamar neurotransmitters a cikin tsarin juyayi na tsakiya kuma suna da tasiri daban-daban, ciki har da daidaitawa na jin zafi da yanayi.
Pentapeptide-18 an haɓaka shi don daidaita aikin waɗannan neuropeptides na endogenous.
Amino acid na biyu na Pentapeptide-18 shine D-alanine, yayin da a cikin enkephalin endogenous wannan matsayi yana shagaltar da shi glycine (Gly).
Amfani da wannan D-amino acid mara kyau yana ba da ingantaccen kwanciyar hankali ga peptide, misali, juriya ga lalacewa ta proteases (musamman aminopeptidases) mai rai.
Wannan canjin yana ƙara rabin rayuwar Pentapeptide-18 a cikin fata don haka yana ba da inganci mai dorewa..
2.Tsarin Aiki
Yanayin aikin Pentapeptide-18 shine don ƙaddamar da mai karɓar enkephalin akan membrane cell na sel neuron..
Yana kunna hanawa G sunadaran (Gi) kan dauri, wanda ke haifar da cascade mai siginar intracellular wanda ke hana tashar calcium mai ƙarfin lantarki da buɗewa tashoshi potassium.
Toshewar shigowar calcium yana danne kai tsaye synaptic vesicle Fusion tare da membrane plasma da sakin acetylcholine.
Neurotransmitter da ke da alhakin raunin tsoka a mahadar neuromuscular shine acetylcholine.
Sakamakon raguwar sa ya ragu tashin hankali na neurons, wanda ke rage girman raunin tsoka kuma yana sauƙaƙa layukan motsa jiki waɗanda motsin fuska ke haifarwa.
3.Nazarin Clinical akan inganci
Kwatancen asibiti na wani kirim mai ɗauke da shi 0.05 kashi Pentapeptide-18 da wani mai dauke da shi Acetyl Hexapeptide-3 (Argireline) aka gudanar a kan 43 mata masu aikin sa kai.
Bayan 28 kwanakin amfani, rukunin Pentapeptide-18-kawai yana da matsakaicin raguwa a zurfin lanƙwasa 11.64%.
Yana raba irin wannan sakamako tare da acetyl hexapeptide-8 (Argireline), amma yana aiki ta hanyar tsari na musamman.
Haɗuwa da duka biyun yana da ƙarin tasiri don aikin rigakafin lanƙwasa.
Matsakaicin rage wrinkle ya kasance 25-47% lokacin da aka tsara shi don ƙunshe da shi 5% acetyl hexapeptide-8 (Argirelox®).
A kara bude-label karatu aka gudanar (20 masu aikin sa kai) gwada babban taro (2%) samar da Pentapeptide-18.
Bayan 28 kwanakin ci gaba da amfani, Silicone impression kimantawa ya nuna a 35% rage zurfin laka a goshi da a 28% rage cikin kafafun hankaka wrinkles a kusa da idanu.
4.Aikace-aikace na zamani da taƙaitaccen bayani
Pentapeptide-18 an gyara shi ta hanyar sinadarai na asali da enkephalin, wani sinadari mai aiki da aka san shi a cikin kula da fata na zamani na rigakafin tsufa.
Ana ƙara shi da farko azaman mai aiki na anti-wrinkle zuwa serums, lotions, creams da masks don ƙarin bayyanar matasa waɗanda ke yaƙi da tasirin ƙwayar tsoka.
COA
HPLC
MS
