Retatrutide

Binciken Fa'idodin Retatrutide：

1. Yana hana Ci abinci, Yana Jinkirta Zubar da Ciki, kuma yana ƙarfafa insulin

1）Mechanism of Action in Control Appetite：

A cikin binciken dabba, masu bincike sun yi azumi namiji beraye masu kiba domin 16 sa'o'i kuma bi da su tare da agonists masu karɓa na glucagon na dogon lokaci, Retatrutide, Gactin peptides, da sauran analogues na GLP-1 don sarrafa nauyi. Nazarin ya kimanta zubar da ciki (GE) jinkiri, nauyin jiki, da cin abinci.

2）Gwace-Glucose-Dogara Gastric Jinkiri:

Musamman, Retatrutide ya jinkirta GE ta hanyar dogaro da glucose. Musamman, kungiyar karba 10 nmol/L Retatrutide ya nuna mafi girman raguwa a cikin nauyin jiki da raguwa mafi girma a cikin cin abinci.

3）Tsarin Tsarin Jijiya ta Tsakiya:

Hakazalika da sauran GLP-1 agonist mai karɓa, Retatrutide yana aiki kai tsaye tsarin juyayi na tsakiya, inganta koshi da rage zubar ciki. Saboda, yana tallafawa ingantaccen maganin kiba.

4）Sakamakon Asara Nauyi Na Gwaji:

Misali, a Phase 2 gwaji na asibiti ya ba da rahoton babban asarar nauyi a cikin manya da masu kiba: 17.5% a 24 makonni da 24.4% a 48 makonni.

2. Nau'in Magani 2 Ciwon sukari

• Wani nau'in binciken kashi na 1b na hawan hawan da ya shafi nau'in 2 masu ciwon sukari suna karɓar allurai na mako-mako na Retatrutide ko wasu magungunan rage glucose, tare da ƙungiyar kulawa ba tare da magani ba.
• Abin mamaki, An samu Retatrutide 100% na maƙasudin asarar nauyi, idan aka kwatanta da kawai 2.1% a cikin ƙungiyar kulawa. Da bambanci, babu wani maganin ciwon suga da aka kai 50% inganci.
• Waɗannan binciken sun nuna a sarari ingancin Retatrutide a cikin sarrafa nau'in 2 ciwon sukari. Duk da haka, illolin da suka fi yawa sune gastrointestinal.
• A lokaci guda, a cikin manya masu kiba, Maganin Retatrutide kuma ya haifar da asarar nauyi mai yawa 48 makonni.

3. Yana Haɓaka Kashe Makamashi

• A matsayin agonist sau uku, Retatrutide yana kunna mai karɓar glucagon daidai da glucagon. Musamman, kai tsaye yana motsa thermogenesis da rushewar mai.
• Yana da mahimmanci a lura cewa masu karɓar glucagon suna cikin hanta kuma adipose nama. Ta hanyar kunna waɗannan masu karɓa, Retatrutide yana ƙaruwa kashe kuzari da samar da zafi a cikin hanta.
• Sakamakon haka, yana haɓaka ƙimar metabolism kuma yana haɓaka iskar oxygenation mai mai.

4. Yana Rage Kumburi da Maganin Ciwon Hanta mai Fat

1）Amfanonin rigakafin kumburi：

Retatrutide yana ba da fa'idodi masu yawa na rigakafin kumburi. Misali, nazarin ya nuna yana inganta jurewar glucose, yana rage nauyin jiki da kitse, da kuma inganta lipid profiles.

2） Juyawar Steatohepatitis a cikin Mice：

Bugu da kari, yana juyawa steatohepatitis a cikin mice mata, goyon bayan ƙuduri na ciwon hanta mai kitse ta hanyar rage hanta steatosis. A cikin binciken daya, berayen da masu bincike suka ciyar da mai mai yawa, high-sukari rage cin abinci 38 makonni sun sami Retatrutide subcutaneous, kuma masu bincike sun yi azuminsu 4 hours.

Daga baya, histological bincike ya nuna a kan 80% yana da tabbataccen steatohepatitis. Mahimmanci, Retatrutide ya inganta yanayin dogaro da kashi, tare da wasu mata suna nuna cikakkiyar juyawa.

3）Sakamakon Binciken Tarihi：

A cikin wani gwaji na ɗan adam, researchers treated 98 participants with ≥10% liver fat content. Bayan 48 weeks of Retatrutide treatment, liver fat decreased by 51.3% (1 MG), 59% (4 MG), kuma 86% (12 MG), compared to 4.6% a cikin ƙungiyar kulawa.

Ultimately, all treated patients achieved normal liver fat levels.