Glycyl-L-Histidyl-L-Lysine, ma ọ bụ GHK, bụ tripeptide mebere ya glycine, histidine, na lysine. Peptide a na-apụta n'ime ahụ mmadụ; plasma ọbara, asu, na mmamịrị niile nwere ya, na ọkwa na-agbada dị ka akụkụ nke usoro ịka nká. GHK na-ejikọta na ions ọla kọpa (Ku²⁺) iji mepụta mgbagwoju GHK-Cu. Mgbagwoju anya n'onwe ya na-eme ka ụzọ mgbaàmà ekwentị dị iche iche rụọ ọrụ; obosara ụdịdị dị iche iche nke ndu mmetụta sitere na nke a ebighị.
Usoro
Gly-His-Lys
Nọmba CAS
49557-75-7
Usoro ihe omimi
C14H24N6O4
Ibu molekụla
340.38
Nnyocha nke GHK/Tripeptide-1
1.Ihe omume Bayolọji dị iche iche
GHK na-arụ ọrụ na ma ihe nrịbama na ikike peptide ebu. Dị ka peptide na-egosi, A na-akpali mkpụrụ ndụ akpụkpọ ahụ ka ọ na-emepụta ụbara ego elastin, proteoglycans, glycosaminoglycans, na n'ikpeazụ collagen. Akụkụ nke ebu na-ebuga ihe dị mkpa Chọpụta mmewere ọla kọpa ozugbo na sel ndị a.
Ọrụ abụọ a na-ahụ maka ọtụtụ ihe omume ndụ GHK gosipụtara – Nrụzi anụ ahụ bụ isi ihe atụ, yana mgbochi mkpali na ama ama antioxidant Njirimara, mmetụta anticancer nwere ike ime, na iche Iwu nke okwu mkpụrụ ndụ ihe nketa.
2.Akpụkpọ anụ Mweghachi Na Mmezi
Ịkwado mmeghari akpụkpọ ahụ bụ otu n'ime mmetụta GHK nke edekọtara nke ọma. Nnyocha na-akwado collagen (na kpọmkwem glycosaminoglycans/decorin) njikọ na-akpali. Iwu igodo metalloproteinase (mmebi nke extracellular matriks ịbụ isi ọrụ ha) na ihe mgbochi protease e gosikwara.
Omume abụọ a kpọtụrụ aha na mbụ na-enye GHK mmetụta nchịkwa zuru oke n'akụkụ niile nke mmebi protein akpụkpọ ahụ; igbochi ma oke mkpokọta protein mebiri emebi na mmebi zuru oke.
3.Antioxidant / mgbochi mkpali Njirimara
Ike antioxidant siri ike na ikike mgbochi mkpali dị iche iche bụ nke GHK nwere. Na-emerụ ahụ n'efu radicals si peroxidation lipid bụ neutralized, keratinocytes A na-echekwa ya kpọmkwem site na mmebi nke UV kpatara. Mgbochi zuru oke nke oxidation dabere na ọla kọpa nke LDL(Lipoprotein dị obere) bụ ihe atụ doro anya ọzọ nke usoro nchebe a.
4.Iwu Nkwupụta Gene
GHK na-akwado nrụzi anụ ahụ njikọ na imezigharị site na okwu mkpụrụ ndụ ihe nketa. Ntughari nke mkpụrụ ndụ ihe nketa mbinye aka nke COPD(Ọrịa Pulmonary na-egbochi oge na-adịghị ala ala) bụ usoro nyocha dị ịrịba ama; 127 mkpụrụ ndụ ihe nketa na-etinye aka na ọrịa ahụ ma egosila GHK iji weghachi ha na ọnọdụ ahụike.
5.Ọmụmụ usoro ihe omimi
Nnyocha na-apụta na-egosi na GHK nwere ike ịtọgharịa mkpụrụ ndụ ihe nketa na okwu protein, na UPS(Sistemụ Ubiquitin-Proteasome) ọrụ, gaa n'ọnọdụ ahụike ka mma.
Mgbochi ịka nká na nkwalite ahụike, n'ihi ihe niile dị n'elu, bụ nnukwu ebumnuche nke ngwa GHK.
Ya mere, ikike ọgwụgwọ ya dị oke egwu.
COA
HPLC
MS
