Myristoyl pentapeptide-17 bụ a peptide bioactive ahaziri na synthesized kpọmkwem iji lebara ezughị oke uto nke nku anya/ntutu eke eke.
E sitere na a 14-18 amino acid Iberibe nke protein ndị metụtara keratin mmadụ KAP5-1, Ọ na-enweta N-terminal myristoylation na C-terminal amidation; nke a na-eme ka ọkara ndụ ya dịkwuo elu, na-enye ohere ịbanye kpọmkwem n'ime mmadụ epidermal akpụkpọ anụ cell.
Myristoyl pentapeptide-17 bụ ugbu a otu n'ime peptides ịchọ mma kachasị ike ejiri na-akwalite uto nku anya., etinyere n'ọtụtụ ngwaahịa mma.
Usoro
Myr-Lys-Leu-Ala-Lys-Lys-NH2
Nọmba CAS
959610-30-1
Usoro ihe omimi
C41H81N9O6
Ibu molekụla
796.16
Nnyocha metụtara Myristoyl Pentapeptide-17
1.Usoro ndu ndu nke izizi
Mma nnyefe arụmọrụ nke KGF(Ihe na-akpata uto Keratinocyte), VEGF(Ihe kpatara uto akwara akwara) na lysophosphatidic acid (LPA) a na-emeziwanye n'ime sel ndị a, na-agbatị usoro ogologo ntutu isi.
A na-egosipụtakwa ihe mgbochi mkpali, na-eme ka ọ dị mma maka anya nku anya, na dị ka ihe mgbakwunye ọgwụgwọ nke androgenic alopecia; ịse foto gburugburu anya ịbụ isi nchegbu.
Na-akwalite follicular mgbasa ọbara bụ isi ihe ọzọ dị mkpa – mmụba ọbara na-eruba na ntutu isi pụtara ụbara nri na nnyefe oxygen, na-eke ebe nri dị mma maka uto ntutu anya.
2.Upregulation nke keratin okwu mkpụrụ ndụ ihe nketa
Iberibe nọ n'ọrụ a kpọtụrụ aha n'elu na-ejigide ọrụ izizi nke mbụ Ndị na-edozi KAP(Keratin Associated Proteins).
Ejide na cationic amino acid transporters, ntụgharị na njikọ nke KAP5-1 na-esote yana keratinsdị I (31 ịbụ onye edekọtara nke ọma) na-emeziwanye.
Ịba ụba nke cortex ntutu ntutu bụ ngosipụta anụ ahụ nke usoro a, A na-abawanye ike nku anya nke ukwuu.
3.Na-akwalite microcirculation/nri ọkọnọ
Myristoyl pentapeptide-17 na-akpali keratinocytes ịhapụ VEGF-A na isi ihe na-eto eto fibroblast(bFGF ma ọ bụ FGF2).
Ntinye ngwa ngwa akpụkpọ ahụ na-eduga na microvessel dermal vasodilation, mmụba ọbara ka mma, emelitere intercellular mgbanwe nri na ụbara ihe oriri na-edozi ahụ na follicle.
Mmetụta mgbochi mkpali bụ akụkụ niile nke ibu, usoro nkwado onwe onye nke nrụzi mgbochi akpụkpọ anụ.
Mbelata oge izu ike nke ntutu isi na ịkwalite ahụike ntutu anya, bụ njedebe nke omume Myristoyl Pentapeptide-17.
COA
HPLC
MS
