Palmitoyl hexapeptide-12 is a synthetic bioactive peptide currently receiving significant attention within modern cosmetics and dermatology. Previously referred to as “palmitoyl oligopeptide” заедно со palmitoyl tripeptide-1 (PAL-GHK), it falls under the more specific categories of Signal Peptides и Matrikines. Designed to mimic naturally occurring biological signals within the skin, these peptides stimulate and promote various forms of the skin’s self-repair and regeneration processes.
Секвенца
Pal-Val-Gly-Val-Ala-Pro-Gly
CAS број
171263-26-6
Молекуларна формула
C38H68N6O8
Молекуларна тежина
736.98 g/mol
Research Of Palmitoyl Hexapeptide-12
Palmitoyl Hexapeptide-12 itself is an еластин фрагмент; the direct stimulation of collagen, еластин, фибронектин, и гликозаминогликан syntheses is its primary mechanism. Improved skin elasticity and firmness – the end desired anti-aging effect – result from this process.
Two closely interconnected pathways are responsible for these anti-aging properties: promoting the aforementioned structural protein synthesis, and to a large extent inhibiting inflammation-induced matrix degradation.
Mimicking said elastin fragments, Palmitoyl Hexapeptide-12 sends these specific biological signals to dermal fibroblasts. Research has shown enhanced migration and (до точка) proliferation of these fibroblasts.
Fibroblasts are the ‘factories’ of the primary structural components of the skin; increased activity of them is the true foundation of skin rejuvenation. Activated fibroblasts massively re-synthesize the aforementioned macromolecules.
Rebuilding dermal structures (degraded by both time and UV) is the end result, macroscopically observed as lessened wrinkles, improved firmness and all related elastic properties.
A double-blind study using a lightweight emulsion with 4% of the peptide was conducted on 10 женски волонтери; еластичност, complexion, perceived fatigue and simple ‘firmness’ all improved.
Reduction of IL-6 production is another quality Palmitoyl Hexapeptide-12 exhibits, key skin cells being affected by external stimuli (UV being the most common).
Maintaining or re-establishing a certain level of homeostasis in the dermis is one of the more ideal end goals of anti-aging treatment.
Palmitoyl Hexapeptide-12 is a well thought out, and to date very successful, bioactive lipopeptide.
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