Semelo sa lipatlisiso le mathata
Ho koaloa ha selikalikoe se ikhethileng sa metsoako e mengata ea sulfhydryl ke mohato oa bohlokoa ho kopanngoeng ha metsoako ea heterocyclic e nang le sulfur., empa mokhoa oa setso o na le mathata a latelang:
- Mesebetsi e mengata ea karabelo ea sulfhydryl e tšoana, ho etsa hore ho be thata ho fihlella taolo e kgethehileng. Maikutlo a mangata a mahlakoreng, lihlahisoa tse rarahaneng, le thata ho arola le ho hloekisa. Maemo a karabelo a boima mme sebaka sa kopo se lekanyelitsoe. Re atlehile ho theha theknoloji e ncha e khethang ea oxidative ea ho koala lesale, e rarollang mathata a ka holimo ka botlalo mme e fihlelle karabelo e ntle le e nepahetseng ea ho koala mehala.
Lintlafatso tsa tekheniki
- Sistimi e ncha ea oxidation: Ho hlahisoa mokhoa oa pele oa alkyne amide-based oxidation, e ntlafatsang haholo khetho.
- Moralo o ikhethileng oa karabelo: ka maemo a fapaneng a fapaneng a substrate ea sulfhydryl, ho koaloa ho nepahetseng ha selikalikoe sa li-multiple sulfhydryl substrates ho fihletsoe.
Melemo ea Setsebi
- Khetho e phahameng: boitsebahatso bo nepahetseng ba libaka tse shebiloeng har'a li-substrates tse ngata tsa sulfhydryl ho fihlela tlhahiso e le 'ngoe ea sehlahisoa.
- Bokgoni bo phahameng: maemo a karabelo a bonolo, mme poelo ya karabelo e ntlafetse haholo.
- Bokahohle: e sebetsang ho kopantseng metsoako e fapaneng ea sebabole e nang le heterocyclic.
Libaka tsa Kopo
- Tšebeliso ea lithethefatsi: kaho ea limolek'hule tsa lithethefatsi tsa heterocyclic tse nang le sebabole (mohlala, thiophene, benzothiophene, dithiopyrrolidine, etc.).
- Lisebelisoa tse sebetsang: ho lokisoa ha lisebelisoa tsa polymer tse nang le sebabole (mohlala. thepa ea ho lokisa, li-polymers tse tsamaisang, etc.).
- Biology ea lik'hemik'hale: ho ithuta sebopeho le tšebetso ea li-protein disulfide bonds.
