Glycyl-L-Histidyl-L-Lysine, kapa GHK, ke tripeptide e entsoeng ka glycine, histidine, le lysine. Peptide ena e hlaha ka tlhaho ka har'a 'mele oa motho; plasma ea mali, mathe, 'me moroto o na le eona kaofela, ka maemo a theohang joalo ka karolo ea botsofali. GHK e tlama li-ion tsa koporo (Cu²⁺) ho theha motsoako oa GHK-Cu. Complex ka boeona e kenya tšebetsong litsela tse fapaneng tsa matšoao a cellular; palo e pharaletseng ea litlamorao tsa bioloji e hlahisoa ke ts'ebetso ena.
Tatelano
Gly-His-Ls
Nomoro ea CAS
49557-75-7
Foromo ea limolek'hule
C14H24N6O4
Boima ba Molek'hule
340.38
Lipatlisiso tsa GHK/Tripeptide-1
1.Mesebetsi e Fetohang ea Likokoana-hloko
GHK e sebetsa ka bobeli boemong ba ho bonts'a le ho tsamaisa peptide. E le pontšo ea peptide, lisele tsa letlalo li susumelletseha ho hlahisa palo e eketsehileng ea elastin, li-proteoglycans, li-glycosaminoglycans, 'me qetellong ke collagen. Karolo ea mokhanni e fana ka lintlha tsa bohlokoa trace element koporo ka ho toba liseleng tsena.
Likarolo tsena tse peli li ikarabella bakeng sa mefuta e mengata e fapaneng ea mesebetsi ea likokoana-hloko lipontšo tsa GHK – ho lokisa lisele e le mohlala o ka sehloohong, hammoho le anti-inflammatory le e hlokomelehang antioxidant thepa, litlamorao tse ka bang teng tsa anticancer, le e ikhethang Taolo ea polelo ea liphatsa tsa lefutso.
2.Letlalo Tsosoloso Le Tokiso
Ho tšehetsa ho tsosolosoa ha letlalo ke e 'ngoe ea liphello tse ngotsoeng ka ho feletseng tsa GHK. Liphuputso li tiisa collagen (le tse tobileng li-glycosaminoglycans/mekhabiso) synthesis ea tsosoa. Taolo ea senotlolo metalloproteinases (ho senyeha ha matrix a extracellular ho ba mosebetsi oa bona oa mantlha) le li-anti-protease le tsona li bontšitsoe.
Ketso e 'meli e boletsoeng pejana e fa GHK phello e felletseng ea taolo likarolong tsohle tsa ho senyeha ha protheine ea letlalo.; ho thibela ka bobeli ho bokellana ho feteletseng ha liprotheine tse senyehileng le ho senyeha ho feletseng.
3.Antioxidant / Anti-inflammatory Thepa
Matla a matla a li-antioxidant le a pharaletseng a anti-inflammatory a na le GHK. E kotsi mahala radicals ho tloha lipid peroxidation ha ba na lehlakore, keratinocyte ka ho khetheha e sirelelitsoeng ho tsenyo e bakoang ke UV. Thibelo e felletseng ea oxidation e itšetlehileng ka koporo ea LDL(Low Density Lipoprotein) ke mohlala o mong o hlakileng oa mokhoa ona oa tšireletso.
4.Gene Expression Regulation
GHK e ts'ehetsa tokiso ea lisele tse hokahaneng le ho nchafatsoa ka liphatsa tsa lefutso. Phetoho ea tekeno ea liphatsa tsa lefutso ea COPD(Boloetse bo sa Feleng bo Thibelang Matšoafo) ke karolo ea bohlokoa ea lipatlisiso; 127 liphatsa tsa lefutso li ameha ho lefu lena 'me GHK e bontšitsoe ho ba khutlisetsa boemong bo botle.
5.Lithuto tsa Mokhoa oa Limolek'hule
Lipatlisiso tse ntseng li hlaha li bontša hore GHK e ka tsosolosa liphatsa tsa lefutso le liprotheine tse sa tšoaneng, le UPS(Sistimi ea Ubiquitin-Proteasome) tshebetso, ho ea boemong bo botle.
Khahlanong le botsofali le ntlafatso ea bophelo bo botle, ka lebaka la tsohle tse ka holimo, ke sepheo se lakatsehang haholo sa ts'ebeliso ea GHK.
Ka hona, bokhoni ba eona ba ho phekola bo bongata.
COA
HPLC
MOF
