Myristoyl pentapeptide-17 ke a peptide ea bioactive ka ho khetheha e etselitsoeng le ho etsoa ho sebetsana le kholo e sa lekaneng ea li-eyelashes / moriri oa tlhaho.
E tsoa ho a 14-18 amino acid sekhechana sa protheine ea motho e amanang le keratin KAP5-1, e kena ho N-terminal myristoylation le C-terminal amidation; sena se ntlafatsa halofo ea bophelo ba eona, ho dumella ho kenella ka kotloloho ho motho epidermal li-membrane tsa lisele.
Myristoyl pentapeptide-17 hajoale ke e 'ngoe ea li-peptide tse matla haholo tse sebelisoang ho khothaletsa kholo ea lintshi., e kenyelelitsoe haholo lihlahisoa tse ngata tsa botle.
Tatelano
Myr-Lys-Leu-Ala-Lys-Lys-NH2
Nomoro ea CAS
959610-30-1
Foromo ea limolek'hule
C41H81N9O6
Boima ba Molek'hule
796.16
Lipatlisiso tse amanang le Myristoyl Pentapeptide-17
1.Mekhoa ea Pele ea Likokoana-hloko
Ntlafatso ea tšebetso ea phano ea KGF(Ntho ea Khōlo ea Keratinocyte), VEGF(Vascular Endothelial Growth Factor) le asiti ea lysophosphatidic (LPA) e nolofalloa ka har'a lisele tsena, ho lelefatsa potoloho ea ho hola ha moriri.
Lintho tse khahlanong le ho ruruha li boetse li bontšoa, ho etsa hore e tshwanele dintshi tse nyane, le e le pheko ea tlatsetso ea androgenetiki alopecia; ho etsa lifoto ho pota-pota mahlo e le taba ea mantlha.
Ho phahamisa follicular ho potoloha ha mali ke phello e 'ngoe ea bohlokoa – phallo ea mali e ntlafetseng ho follicle ea moriri e bolela ho eketseha ha limatlafatsi le phepelo ea oksijene, ho theha tikoloho e nepahetseng ea phepo bakeng sa kholo ea lintši.
2.Phahamiso ea keratin polelo ea lefutso
Sekhechana se sebetsang se boletsoeng ka holimo se boloka mosebetsi oa mantlha oa mantlha Liprotheine tsa KAP(Liprotheine tse amanang le Keratin).
Tlama ho li-transporter tsa cationic amino acid, ho ngoloa le tlhahiso e latelang ea KAP5-1 le mofuta oa I keratin (31 ho ba yona e ngotsweng hantle ka ho fetisisa) e laoloang.
Ho teteka ha cortex ea moriri oa moriri ke pontšo ea 'mele ea mokhoa ona, matla a li-eyelashes a eketseha haholo.
3.Ho phahamisa microcirculation/phepelo ea limatlafatsi
Myristoyl pentapeptide-17 e susumetsa keratinocyte ho lokolla VEGF-A le lintlha tsa motheo tsa kholo ea fibroblast(bFGF kapa FGF2).
Ho kenella ka potlako ha membrane ho lebisa ho dermal microvessel vasodilation, phallo ea mali e ntlafetseng, matlafatsa intercellular phapanyetsano ea limatlafatsi le ho eketsa phepelo ea limatlafatsi follicle.
Litlamorao tse khahlanong le ho ruruha kaofela ke karolo ea e kholoanyane, mokhoa o ikemetseng oa ho lokisa mokoallo oa letlalo.
Ho khutsufatsa karolo ea ho phomola ea follicle ea moriri le ho khothalletsa bophelo bo botle ba lintši, ke phello ea ho qetela ea liketso tsa Myristoyl Pentapeptide-17.
COA
HPLC
MOF
