Oligopeptide-41

Oligopeptide-41 Related Research

1.Mechanisms of Action and Efficacy

Experiments have shown this peptide activating dual pathways – β-catenin/Wnt and JAK-STAT5 – in ORSc stem cells; upregulation of related protein expression and anti-apoptotic factors follow.

Prolonging the growth phase of the hair follicle is the direct result, melanocyte stem cell differentiation being promoted, gray hair prevalence greatly reduced.

Local microcirculation is enhanced, antioxidant capacity of melanocytes boosted and hydrogen peroxide levels lowered.

2.Triple efficacy is thus achieved

prevention of hair loss, promotion of active hair growth, delaying or stopping graying altogether.

3.Extending the Anagen Phase

Binding to FGFR2-IIIb receptors on the follicular cell surface induces receptor dimerization and subsequent phosphorylation.

The Wnt/β-catenin pathway is activated, keratinocyte precursors remain in a stem state, terminal differentiation delayed.

Ex vivo human hair follicle culture models have demonstrated a clear and measurable increase in both duration and density of the anagen phase.

4.Activating melanocyte stem cells and inhibiting gray hair

Pax3 and MITF-M gene expression are upregulated.

Differentiation into mature melanocytes is promoted.

Clinical trials support all of the previously mentioned benefits of Oligopeptide-41.

Additional functions of the peptide are being studied, but all are linked to the earlier defined pathways.

New microcirculatory and anti-inflammatory effects are of particular interest to the future of hair and skin health.