Cagrilintide bụ analog nke amylin na-eme ogologo oge. Amylin bụ hormone peptide jikọtara ya na ya mkpụrụ ndụ β-pancreatic n'okpuru insulin; na-achịkwa nguzozi ike site na satiety, igbu oge na-egbu oge, na mgbochi glucagon.
Otú ọ dị, amylin na-emekarị, na-agbakọta ngwa ngwa ma nwee nkwụsi ike na-adịghị mma, na-amachi ngwa ụlọ ọgwụ ha. Amylin sitere na mbụ analogs dị ka pramlintide chọrọ injections ugboro ugboro n'ihi suboptimal pharmacokinetics maka mmetụta ọgwụgwọ n'ụdị 2 ọrịa shuga mellitus.
Cagrilintide na-arụ ọrụ ogologo oge a site na mgbanwe yinye acid fatty pụrụ iche – otu ugboro kwa izu dose bụ ihe njedebe a na-achọ. Nnwale ụlọọgwụ egosila mmetụta na-ebelata agụụ, A na-egosipụta usoro mmekọ nke ime ihe ma e jiri ya tụnyere semaglutide.
Ngwakọta oke edoziri (CagriSema) emebela ya. Data mbelata ibu nnwale na-egosi na nchikota karịrị otu onye ọrụ naanị na arụmọrụ.
Ọganihu cagrilintide na-aga n'ihu na-agbasawanye ikike ọgwụgwọ akọwapụtara nke mbụ nke amylin mimetics.; multi-lekwasịrị synergistic ọgwụgwọ nke metabolic ọrịa bụ doro anya ga-eme n'ọdịnihu ntụziaka.
Usoro
{Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Thr-Asn-Pro-Asn-Pro-H (Disulfide akwa:Cys3-Cys8)
Nọmba CAS
1415456-99-3
Usoro ihe omimi
C194H312N54O59S2
Ibu molekụla
4409.01 g/mol
Nnyocha metụtara Cagrilintide
1.Mbelata agụụ na nkwalite afọ ojuju
Dị ka amylin analogues, Ịgafe ngwa ngwa nke mgbochi ụbụrụ ọbara bụ isi ihe kpatara mmetụta Cagrilintide.
Ezubere iche kpọmkwem mpaghara ụbụrụ ụfọdụ na-achịkwa agụụ dị ọcha’ bụ ihe na-ekewa ya – ebighị nke calcitonin receptor (akara ngosi ike zuru oke) na-ebelata, ma ọ bụrụ na ọ bụghị na-ewepụ, Agụụ nri centrally.
Nri dabere n'ike n'ike enweghị ike ịmegharị mgbanwe physiological a na ebe a tọhapụrụ onye ọ bụla.
2.Igbu oge na mkpofu afọ na mgbaze niile na-esote
Mgbochi nke mgbakasị ahụ dị nro nke eriri afọ na izu ike nke pylorus na-enye ụdị anụ ahụ karịa nke na-adịgide adịgide..
A na-ebelata nnabata nke nri, glucose ọbara postprandial (na n'ụzọ dị ukwuu, usoro metabolic niile) a na-edobe ya ka o kwere mee.
3.Na-egbochi mpụta glucagon postprandial
Glucagon bụ homonụ na-akwalite ịba ọcha n'anya glycogenolysis na gluconeogenesis; na-eje ozi nke ọma dị ka a hyperglycemic ọgwụ.
Cagrilintide na-eṅomi nzuzo nzuzo nke postprandial mkpụrụ ndụ alfa mee, na-egosi site na ụbụrụ ụbụrụ ụbụrụ na ntọhapụ a mere.
Mbelata dị ịrịba ama na nzuzo kwuru bụ njedebe ikpeazụ – ibelata glucose ọbara mgbe nri gasịrị bụ otu n'ime uru ndị bụ isi.
Imelite usoro nri maka ụdị 2 Ndị ọrịa shuga nwere njikọ chiri anya na usoro a; na-eri ụdị ike dị iche iche’ enwere ike ịbịakwute ya na ntụkwasị obi zuru oke na-enweghị nlele glucose mgbe niile.
4.Mmekọrịta mmekọrịta na GLP-1 Nnabata Agonists
A na-egosipụta usoro nkwado dị ukwuu n'etiti cagrilintide na agonists ndị a.
GLP-1 n'onwe ya na-elekwasị anya karịa na satiety, mgbe amylin analogues (ruo n'ókè zuru oke nso) gbochie ụdị agụụ ọ bụla.
Usoro abụọ, otutu ezubere iche pathophysiology dabere na ụzọ oke ibu na ọrịa shuga bụ ihe ngwakọta na-enye.
Ọmụmụ (CagriSema bụ ihe kacha ọhụrụ) egosila oke ibu dị elu yana njikwa glycemic ka mma mgbe ejikọtara ha abụọ ọnụ.
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