As a structural analog of α-MSH (melanocyte-stimulating hormone), Melanotan-II (MT-II) exhibits properties similar to α-MSH. It acts as a non-selective melanocortin receptor agonist, demonstrating activity at melanocortin receptors MC1R, MC3R, MC4R na MC5R.
Structurally, Melanotan-II is a cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-NH₂). This cyclized architecture affords a shorter peptide chain than the linear MT-I.
Although in vitro studies indicate Melanotan-II exhibits weaker efficacy than Melanotan-I in activating melanocyte MC1R to induce pigmentation, Melanotan-II has been found to possess potential advantages in other aspects, particularly in central nervous system regulation.
Usoro
Ac-{Nwere ike}-Asp-Hi-{d-Phe}-Arg-Trp-Lys-NH2, (2→7)-lactam
Nọmba CAS
121062-08-6
Usoro ihe omimi
C50H69N15O9
Ibu molekụla
1024.18
Research Of Melanotan-II
1.what is melanotan-II
1)Discovery and Development
Melanotan-II is a synthetic melanocortin receptor agonist initially developed for skin cancer protection. Agbanyeghị, nchoputa ya a na-atụghị anya ya nke sistemu ụjọ nke etiti yana mmetụta nchịkwa ọrụ mmekọahụ agbasawanyela ngwa ya nwere ike gafee ọtụtụ mpaghara..
2) Mmetụta Pigmentation Skin
Dị ka analọg nke α-MSH, Melanotan-II nwere ike ime ka melanocytes rụọ ọrụ ma mee ka akpụkpọ anụ. N'ime ọmụmụ otu-ìsì, Ndị sonyere atọ nwetara saline ma ọ bụ Melanotan-II site na ntụtụ subcutaneous otu ugboro kwa ụbọchị n'ụbọchị izu ụka maka izu abụọ.
A na-emegharị ihe n'otu saịtị ahụ n'ụbọchị 21. Ntụle a na-ahụ anya gosipụtara ncha ihu n'ihu na ndị sonyere na-esochi nchịkwa. Ihe akaebe na-egosi na Melanotan-II na-akwalite tanning site na omume ya dị ka agonist na MC1R na melanocytes¹.
3)Ọgwụgwọ adịghị arụ ọrụ erectile
Melanotan-II nwere ike na-agwọ ọrịa erectile nwoke (ED). N'ime obere ìgwè nke 10 ndị ọrịa nwere psychogenic ED, subcutaneous injection nke peptide (0.025 mg/kg arọ ahụ) A tụlere site na nleba anya n'ime 6 awa: 8 ụmụ nwoke nwetara erections nke ọma na ụlọ ọgwụ².
Emechara kwenye nchoputa ndị a n'ime ọmụmụ ihe ejiri kpuo ìsì³.
4)Mmetụta Metabolic
Ọmụmụ anụmanụ egosila na Melanotan-II na-egbochi agụụ ma na-akwalite abụba ọkụ. Ndị nchọpụta kpọpụrụ ya kpọmkwem PTP1B(Protein Tyrosine Phosphatase 1B) mkpụrụ ndụ ihe nketa (onye na-achịkwa ihe na-adịghị mma nke akara leptin) n'ime POMC(Proopiomelanocortin) neurons nke oke.
Oke ụmụ oke ndị a gosipụtara nzaghachi siri ike maka intracerebventricular injections nke leptin na Melanotan-II (melanocortin agonist receptor), na-egosipụta dị ka mmụba agụụ agụụ, arọ ọnwụ, na thermogenic nzaghachi.
Ọzọkwa, Mwechapụ mkpụrụ ndụ ihe nketa a rụpụtara mmụba nkwupụta nke nnabata MC4R na ụmụ oke.
2.Mmechi
Melanotan-II, dị ka onye na-adịghị ahọrọ melanocortin agonist receptor, Ọ bụghị nanị na-egosi nkwa maka ịkpata pigmenti akpụkpọ ahụ kamakwa ọ nwetawo mmasị dị ukwuu nke sayensị maka mmetụta ya na-arụ ọrụ nke ọma na nhazi ọrụ mmekọahụ., karịsịa n'ịkwalite ED.
Nsonaazụ ụlọ ọgwụ izizi ya na ọgwụgwọ ED na-agba ume, na ya pleiotropic Usoro nke ime ihe na-eguzobe ntọala na-ekwe nkwa maka mmepe nke usoro ọgwụgwọ ED ọhụrụ.
COA
HPLC
MS
