Cagrilintide ke analoge ea amylin ea nako e telele. Amylin ke hormone ea peptide e kopantsoeng ke lisele tsa pancreatic β hammoho le insulin; ho laola botsitso ba matla ka ho kgora, ho lieha ho tsoa ka mpeng, le thibelo ea glucagon.
Ka tlhaho amylin leha ho le joalo, li bokellana habonolo 'me li na le botsitso bo fokolang, ho fokotsa ts'ebeliso ea bona ea bongaka. Li-analogues tsa pele tse tsoang ho amylin joalo ka pramlintide e hloka liente khafetsa ka lebaka la suboptimal pharmacokinetics bakeng sa litlamorao tsa kalafo ka mofuta 2 lefu la tsoekere.
Cagrilintide e fihlela ketso ena ea nako e telele ka phetoho e ikhethang ea ketane ea mafura – hang ka beke dosing ke ntlha ea ho qetela e batloang. Liteko tsa kliniki li bonts'itse litlamorao tse hatellang tsa takatso ea lijo, mokhoa o tlatsetsang oa ts'ebetso o bontšoang ha o bapisoa le semaglutide.
Motsoako o tsitsitseng oa karolelano (CagriSema) e entsoe. Lintlha tsa liteko tsa ho theola boima ba 'mele li bontša hore motsoako o feta moemeli a le mong ka katleho.
Tsoelo-pele e tsoelang pele ea cagrilintide e holisa bokhoni bo boletsoeng esale pele ba kalafo ea amylin mimetics.; Phekolo ea li-synergistic tse ngata tsa mathata a metabolic ke tataiso e hlakileng ea bokamoso.
Tatelano
{Eicanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Thr-Asn-Val-Thr-Val-Gly- (Borokho ba disulfide:Cys3-Cys8)
Nomoro ea CAS
1415456-99-3
Foromo ea limolek'hule
Setšoantšo sa C194H312N54O59S2
Boima ba Molek'hule
4409.01 g/mol
Lipatlisiso tse amanang le Cagrilintide
1.Khatello ea Takatso le Ntlafatso ea Khotso
Joalo ka analoge ea amylin, ho tšela ka potlako mokoallo oa boko ba mali ke senotlolo sa phello ea Cagrilintide.
Tsepamiso e tobileng ea libaka tse itseng tsa boko tse laolang "tlala".’ ke eona e e khethollang – ts'ebetsong ea calcitonin receptor (pontšo ea ho lekana ha matla) fokotsa, ha e se e felisa, takatso ea lijo bohareng.
Boikoetliso bo itšetlehileng ka boithatelo bo ke ke ba fetola phetoho ena ea 'mele sebakeng se behiloeng sa motho.
2.Ho lieha ho tsoa ka mpeng le tšilo eohle e latelang
Ho thibela ho honyela ha mesifa ea gastric boreleli le ho phomola ha karolo ea pylorus ho fana ka mofuta o eketsehileng oa 'mele oa botlalo bo tsitsitseng..
Ho monya limatlafatsi hoa fokotseha, tsoekere ea mali ea postprandial (mme ka tekanyo e kholo likarolo tsohle tsa metabolic) li bolokoa li tsitsitse kamoo ho ka khonehang.
3.E thibela tlhahiso ea glucagon ea postprandial
Glucagon ke hormone e khothalletsang sebete glycogenolysis le gluconeogenesis; ka katleho ho sebetsa joalo ka moemeli oa hyperglycemic.
Cagrilintide e etsisa secretion e khethehileng ea postprandial eo lisele tsa alpha etsa, ho bontša ka tsamaiso ea methapo ea boko hore tokollo ena e etsahetse.
Ho fokotseha ho hoholo ha sephiri se boletsoeng ke sephetho – Ho theola tsoekere ea mali ka mor'a lijo ke o mong oa melemo ea mantlha.
Ho ntlafatsa mekhoa ea lijo bakeng sa mofuta 2 bakuli ba lefu la tsoekere ba amana haufi-ufi le mokhoa ona; ho ja mefuta e fapaneng ea matla’ e ka atameloa ka kholiseho e haufi-ufi ntle le ho lekola tsoekere kamehla.
4.Ketso ea Synergistic ka GLP-1 Receptor Agonists
Mekhoa e tlatselletsang haholo e bonts'oa lipakeng tsa cagrilintide le li-agonists tsena.
GLP-1 ka boeona e tsepamisitse maikutlo haholo ho satiety, ha li-analogue tsa amylin (ho isa tekanyong e batlang e phethahetse) thibela mefuta eohle ea tlala.
Mokhoa o habeli, e tjametsoeng ka bongata pathophysiology mokhoa o thehiloeng ho botenya le lefu la tsoekere ke seo motsoako o fanang ka sona.
Lithuto (CagriSema e le ea morao-rao) li bontšitse tahlehelo e phahameng ea boima ba 'mele le taolo e ntlafetseng ea glycemic ha ka bobeli li sebelisoa hammoho.
COA
HPLC
MOF
