E le analoge ea sebopeho sa α-MSH (hormone e susumetsang melanocyte), Melanotan-II (MT-II) e bonts'a thepa e ts'oanang le α-MSH. E sebetsa joalo ka e sa khethoeng melanocortin receptor agonist, ho bonts'a ts'ebetso ho li-receptor tsa melanocortin MC1R, MC3R, MC4R le MC5R.
Ka sebopeho, Melanotan-II ke cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Ls]-NH₂). Meaho ena ea libaesekele e fana ka ketane e khuts'oane ea peptide ho feta MT-I ea mola.
Leha lithuto tsa in vitro li bonts'a Melanotan-II e bonts'a ts'ebetso e fokolang ho feta Melanotan-I ha e kenya tšebetsong. melanocyte MC1R ho susumetsa mmala, Melanotan-II e fumanoe e na le melemo e ka bang teng likarolong tse ling, haholo-holo taolong ea tsamaiso ea methapo e bohareng.
Tatelano
Ak-{Ka}-Asp-Hae-{d-Phe}-Arg-Trp-Lys-NH2, (2→7)-lactam
Nomoro ea CAS
121062-08-6
Foromo ea limolek'hule
Setšoantšo sa C50H69N15O9
Boima ba Molek'hule
1024.18
Lipatlisiso tsa Melanotan-II
1.melanotan-II ke eng
1)Ho sibolloa le Ntlafatso
Melanotan-II ke "melanocortin receptor agonist" ea maiketsetso e qapiloeng bakeng sa ts'ireletso ea mofetše oa letlalo. Leha ho le joalo, ho sibolloa ha eona ho sa lebelloang ha tsamaiso ea methapo e bohareng le litlamorao tsa taolo ea ts'ebetso ea thobalano e atolositse ts'ebeliso ea eona ho pholletsa le masimo a mangata..
2) Liphello tsa Pigmentation ea Letlalo
E le analoge ea α-MSH, Melanotan-II e ka kenya tšebetsong melanocyte 'me ea etsa hore letlalo le fifale. Thutong ea sefofu se le seng, barupeluoa ba bararo ba amohetse saline kapa Melanotan-II ka ente ea subcutaneous hang ka letsatsi ka matsatsi a beke bakeng sa libeke tse peli..
Litekanyo li ile tsa phetoa sebakeng se le seng ka letsatsi 21. Tekolo ea pono e ile ea senola mebala ea sefahleho e hlokomelehang ho barupeluoa kamora tsamaiso. Bopaki bo bontša hore Melanotan-II e khothalletsa ho fifala ha letlalo ka ketso ea eona e le agonist ho MC1R ka melanocytes¹.
3)Phekolo ea ho se sebetse ha Erectile
Melanotan-II e ka phekola ho se sebetse ha erectile ho banna (ED). Ka sehlopha se senyenyane sa 10 bakuli ba nang le psychogenic ED, ente e ka tlas'a letlalo ea peptide (0.025 mg/kg boima ba mmele) e ile ea hlahlojoa ka ho beha leihlo ka nako ea sebele 6 lihora: 8 banna ba fihletse li-erections tse nang le morero².
Liphuputso tsena li ile tsa netefatsoa hamorao thutong e laoloang ka bofofu habeli³.
4)Liphello tsa Metabolic
Liphuputso tsa liphoofolo li bontšitse hore Melanotan-II e thibela takatso ea lijo 'me e khothalletsa ho chesa mafura. Bafuputsi ka ho khetheha ba ile ba senya PTP1B(Protein Tyrosine Phosphatase 1B) lefutso (taolo e mpe ya pontsho ya leptin) ho POMC(Proopiomelanocortin) methapo ea kutlo ea litoeba.
Litoeba tsena tse fetotsoeng li bontšitse likarabelo tse matla ho liente tsa intracerebroventricular ea leptin le Melanotan-II (agonist ea melanocortin receptor), ho bonahala joalo ka khatello e matlafatsoang ke takatso ea lijo, tahlehelo ea boima ba 'mele, le thermogenic likarabo.
Ho feta moo, ho hlakolwa hona ha lefutso ho entse hore ho be le ponahalo e eketsehileng ya MC4R receptor ho dipeba⁴.
2.Qetello
Melanotan-II, joalo ka moamoheli ea sa khetheng oa melanocortin, ha e bonts'e feela ts'episo ea ho etsa hore letlalo le be le 'mala, empa e boetse e khahliloe ke mahlale a bohlokoa bakeng sa litlamorao tsa eona tse bohareng mabapi le taolo ea ts'ebetso ea thobalano., haholo-holo ho ntlafatsa ED.
Liphetho tsa eona tsa pele tsa kliniki kalafong ea ED lia khothatsa, le eona pleiotropic Mokhoa oa ts'ebetso o theha motheo o ts'episang bakeng sa nts'etsopele ea litlhare tsa ED tse ncha.
COA
HPLC
MOF
