Hexapeptide-1 bụ peptide dị mkpụmkpụ sịntetik emebere site na njikarịcha nhazi nke isi iberibe endogenous. α-melanocyte - hormone na-akpali akpali (α-MSH).
Ọ na-echekwa ọrụ ndu nke α-MSH, ma na-abawanye nkwụsi ike ya na onye nnata nhọrọ na amino acid nnọchi (eg, dochie methionine na Nle na iwebata nhazi D na ọnọdụ Phe).
Usoro
Nle-Ala-His-DPhe-Arg-Trp-NH2
Nọmba CAS
/
Usoro ihe omimi
C41H57N13O6
Ibu molekụla
828.0
Nnyocha metụtara Hexapeptide-1
α-MSH bụ ihe dị mkpa na-achịkwa peptide na vivo, yana obere usoro arụ ọrụ nke "His-Phe-Arg-Trp" achọrọ maka ịgbalite nke ndị na-anabata melanocortin (Ndị MCR) a kọwapụtala 1.
Hexapeptide-1 bụ ndọtị nke usoro isi dị n'elu nke etinyere Nle na Ala na ya. NH(₂)-njedebe, na-ebute usoro hexapeptide nke ndị a: Nle-Ala-His-DPhe-Arg-Trp-NH₂.
Nhazi a abụghị naanị na-ejigide usoro nrịbama dị oke egwu kamakwa ọ na-abawanye hydrophobicity na Nle ma kwalite nkwụsi ike enzymatic site na D-Phe, si otú a na-egosipụta ọrụ emelitere na ogologo ndụ ọkara ndụ ma in vitro ma in vivo ma e jiri ya tụnyere nke iberibe ala..
N'ihi ya, Hexapeptide-1 bụ molekul ngwá ọrụ dị mkpa maka nyocha ọrụ MCR na ihe ngosi ọgwụgwọ metụtara..
Hexapeptide-1 na-arụ ọrụ tumadi na ezinụlọ nke ndị na-anabata melanocortin (MC1R, MC3R, MC4R, MC5R).
N'ime ndị a, A na-egosipụta MC1R nke ukwuu na melanocytes akpụkpọ ahụ, keratinocytes na sel ndị na-alụso ọrịa ọgụ ma bụrụ onye nnabata etiti na-achịkwa pigmentation akpụkpọ ahụ, mbufụt na mgbochi.
(1).njikwa mmepụta nke Melanin
Dị ka MC1R agonist, Hexapeptide-1 jikọtara na MC1R iji mee ka adenylate cyclase rụọ ọrụ-cAMP-Ụzọ mgbama PKA.
Nke a n'aka enwekwu ọrụ nke tyrosinase, nke na-eme ka njikọ na njem nke melanin dị ngwa ngwa.
Usoro ihe abụọ a na-enyere ngwa ya aka n'ebumnobi ịchọ mma abụọ yiri ka ọ na-emegide: Akpụkpọ anụ na tanning artificial.
Na pigmenti ekpochapụ naanị ebe, enwere ike iji ya belata ihe ize ndụ nke ntụpọ, mgbe ejikọtara ya na ihe ndị ọzọ na-enwu ọkụ na ntinye uche (arbutin na vitamin c).
Ojiji adịghị mma, n'akụkụ aka nke ọzọ, na-enyere gị aka inwe ọdịdị anwụ na-acha nke ọma n'oge tanning.
(2)Mgbochi mkpali na mgbochi mgbochi
Nkwalite MC1R na-egbochikwa NF-κB ụzọ mgbaàmà mkpali metụtara nke, n'oge ya, na-ebelata mmepụta nke ihe ndị na-akpata mkpali (eg., TNF-a, IL-6) iji melite ọbara ọbara na mgbakasị ahụ nke UV ma ọ bụ kemịkalụ mgbakasị ahụ na-akpata.
Na mgbakwunye, Hexapeptide-1 na-ahazi ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ bi na akpụkpọ ahụ iji nyere aka na iweghachi ihe mgbochi akpụkpọ ahụ mebiri emebi..
Ya mere ọ dị mma maka ngwaahịa nrụzi akpụkpọ anụ na post usoro.
(3).Iweghachite na mgbochi-ahịhịa
E gosipụtara Hexapeptide-1 ka ọ na-edozi E-cadherin okwu na nyocha na nso nso a, nke na-akwalite adhesion n'etiti keratinocytes, ma na-agbake ngwa ngwa nke akpụkpọ ahụ.
N'otu oge ahụ, ọ na-emekwa ka ọ rụọ ọrụ fibroblasts na-apụtaghị ìhè site n'ụzọ akara CAMP iji kpalite ọgbọ collagen na elastin.
Nke a na-eme ka akpụkpọ ahụ dịkwuo mma ma belata ahịrị dị mma, sagging iji nweta mmetụta mgbochi ịka nká ndị ọzọ.
Hexapeptide-1 bụ ngwakọta nke bayoloji owuwu na dermatology na-arụ ọrụ.
Site na mgbanwe ezi uche nke usoro isi nke α-MSH eke, nke a dị mkpụmkpụ peptide na-egbuke egbuke, mgbochi mbufụt mmezi na mgbochi ịka nká multifunctions.
Nchoputa ya na-enye uzo ozo n'uzo ihe eji eme ihe ịchọ mma di ugbua ma webata atumatu ohuru maka ọgwụgwọ nke nsogbu pigmenti., ịse foto, na mmetụta anụ ahụ.
COA
HPLC
MS
