Nke Mazduts,Amara ọzọ dị ka IBI362 ma ọ bụ LY3305677, bụ ọhụrụ dual agonist ezubere iche abụọ glucagon-dị ka peptide-1 nnabata (GLP-1R) na onye na-anabata glucagon (GCGR). Na-eje ozi dị ka onye na-egbochi oke ibu, ọ na-ebelata ibu ahụ, glucose ọbara,ọbara mgbali elu, na ọtụtụ nsogbu ndị ọzọ metụtara oke ibu.
Ewubere mmepe nke ogige a na nghọta miri emi karịa oxyntomodulin' physiological ọrụ; Hormone intestinal eke nwere ihe mejupụtara GLP-1 na ọrụ glucagon. Mazdutide n'onwe ya bụ analọg sịntetik sitere na oxyntomodulin, na ogologo acyl abụba n'akụkụ yinye kpọmkwem engineer na-agbatịkwu ogologo oge nke omume (na-eme ka ịdoụ ọgwụ otu ugboro kwa izu).
E wezụga mfe arọ ọnwụ, nnyocha e mere gosiri na ọ na-akpali mmepụta insulin (na oke), na-eweda ala uric acid ọkwa, na-ebelata nrụgide oxidative, ma ọ dịkarịa ala na-ebelata ụfọdụ ọrịa akụrụ.
Usoro
Ya -{Aịb}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
Nọmba CAS
2259884-03-0
Usoro ihe omimi
C209H319N45O68
Ibu molekụla
4563.06
Nnyocha nke Mazdutide
1.Mbelata ibu na mbelata agụụ
Ọmụmụ ihe izu iri na abụọ tụlere mgbanwe na agụụ na ibu ahụ n'ime ụmụ oke na-enye mkpokọta mazdutide dị iche iche..
Dị mkpa, Ahụrụ mbelata dabere na dose na ịdị arọ ahụ, na elu doses na-adị irè karị.
Akụkụ histological anụ ahụ na-enye nkwado ọzọ maka mmetụta a – Hepatic steatosis na mbufụt metụtara na-ebelata nke ọma.
Mazdutide-HD (ụdị dose dị elu) gosipụtara mmetụta hepatoprotective kachasị ike ma e jiri ya tụnyere Dulaglutide.
2.Omume moto emelitere yana omume nyocha
Na-eso 30 ụbọchị nchịkwa na-aga n'ihu, ụmụ oke ejiri mazdutide gwọchara gosipụtara nkwalite mmụta doro anya karịa otu njikwa, nwere mmetụta pụtara ìhè karịa dulaglutide.
Nnwale nhụsianya nke ọgụgụ isi na-akwado mmetụta ọgwụgwọ mazdutide nwere na ọrụ ọgụgụ isi..
3.Nhazi moto emelitere, Nhazi na omume ndị metụtara nchegbu
Nnwale ọkụ nguzozi gosiri ụmụ oke na-enye mazdutide ka ọ ka mma nke ukwuu (ngafe oge na ihe ịga nke ọma ọnụego) karịa akara ụmụ oke.
Nnwale ndị metụtara ọgụgụ isi na nchekasị na-akwadokwa nsonaazụ ndị a.
4.Imelite na imezi mmebi akwara na ọnwụ
Nke hippocampus na-etinye aka na mmụta na ncheta; ọrụ cognitive na-ejikọta ya na usoro ndị a.
Nnyocha akụkọ ihe mere eme nke akụkụ neuronal hippocampal mebiri emebi na-egosi na Mazdutide opekata mpe na-ebelata ụdị a nke mfu neuronal..
A na-ahụkwa nchekwa nke alaka dendritic na usoro dị iche iche nke njupụta spain n'ime mpaghara hippocampal.; mmetụta neuroprotective ndị ọzọ akọwapụtara na CA1(mpi Amọn 1) na CA3(mpi Amọn 3) subfields nwere mmasị pụrụ iche.
5.Na-egbochi Myelin Myelin
Myelination n'onwe ya na-arụ ọrụ dị oke mkpa na mmụta moto, nzaghachi na-agbanwe agbanwe na ụdị ọ bụla nke ihe mmetụta uche site na nzaghachi gburugburu ebe obibi mgbe niile.
A na-enye mkpuchi mkpuchi axonal zuru oke na nkwado nri maka ọrụ sistemu ụjọ myelin.
Myelin remodeling (usoro jikọtara chiri anya na ezi myelation) bụ ma bụrụ akụkụ dị mkpa nke okenye CNS(Sistemụ akwara ozi etiti) ahụike.
LFB(Luxol Fast Blue) ntụpọ ekpughere demyelination nke ọkpụkpụ azụ azụ; Otu mazdutide gosipụtara n'ọbọ myelin ahaziri nke ọma, demyelination na-adịchaghị njọ bụ nsonaazụ ọgwụgwọ kpọmkwem.
A na-ewere ichekwa iguzosi ike n'ezi ihe myelin ugbu a dị ka ebumnuche enwere ike – na-egbu oge mmalite na nwayọọ ọganihu nke Ọrịa Alzheimer ịbụ otu n'ime ebumnuche ọgwụgwọ na-ekwe nkwa nke nyocha dị otú ahụ.
COA
HPLC
MS
