P21 peptide bụ ihe na-ahọrọ nke ukwuu sịntetik peptide onyinye na elu ụbụrụ mgbochi permeability. E sitere na nyocha sara mbara na ihe na-akpata neurotrophic ciliary (CNTF), CNTF n'onwe ya bụ ihe na-emekarị cytokine n'ime neurons; a multifunctional ihe na-akpata neurotrophic.
Ndị ọkà mmụta sayensị chọpụtara, Otú ọ dị, na usoro CNTF eke dị mgbagwoju anya; ike ịgafe mgbochi ụbụrụ ọbara, immunogenicity ihe ize ndụ, na obere ndụ ọkara dị mkpụmkpụ niile na-eweta nnukwu ihe ịma aka maka nyocha ụlọ ọgwụ.
Nyocha nke mkpụkpụ na nyocha ugboro ugboro mere ka a mata akụkụ isi, Ac-DGGL-NH₂. Nnyocha ọmụmụ vitro gosiri na iberibe a na-ejigide ọrụ mbụ neurotrophic, mana enwere ike ọgwụgwọ ọzọ niile ma ka dị oke.
Ihe mgbochi ndị bụ isi bụ mbelata ihe mgbochi ụbụrụ ọbara na-adịghị mma na nso nso a na-emebi ngwa ngwa site na proteases plasma.; dị nnọọ ala bioavailability na vivo bụ njedebe ikpeazụ.
Iji dozie nsogbu ndị a, usoro tricyclic lipophilic dị ukwuu – adamantane oke – ewebata. Mgbanwe a kwalitere ikike P21 nke ọma, mgbochi siri ike na-enye opekata mpe nchekwa nke peptide N-terminal si protease mbuso agha.
Emelitere metabolic kwụsie ike na ọkara ndụ gbatịpụrụ nke ukwuu sochiri ya dị ka nsonaazụ ozugbo.
N'ozuzu, A na-enweta ihe pụrụ iche na nke akọwapụtara nke ọma nke mmetụta akwara ozi na omume site na imewe P21.
Usoro
Ac–asp-gly-gly-leu-adamantane-NH2
Nọmba CAS
/
Usoro ihe omimi
C27H41N5O9
Ibu molekụla
579.65
Nchọpụta metụtara P21 Peptide
1.Ọrụ ndu nke CNTF
Na agafe na-akwalite ndụ neuron moto, na-akpali ụdị dị iche iche nke neurotransmitter njikọ, na-ebute uto axon neuronal, na ichebe ma neurons na sel ha na-akwado site na excitotoxicity na ụfọdụ ụdị mmebi mmebi, CNTF na-arụ ọrụ ụzọ mgbaama akọwapụtara na hypothalamus – satiety na-abawanye bụ otu n'ime mmetụta ndị edepụtara nke ọma.
2.Ịrụ ụlọ ọgwụ na Njirimara Neuroprotective
Nnwale ụlọọgwụ egosila P21 nwere ọrụ ọgwụ kachasị elu ma e jiri ya tụnyere CNTF. Hippocampal neurogenesis, ụdị nile nke synaptik plasticity, ikike mmụta na ọrịa dị iche iche nke ọgụgụ isi na-emetụta nke ọma.
Mmetụta neuroprotective (ischemia / reperfusion, neuroinflammation na nrụgide oxidative) a na-ahụkwa, na-achịkwa, nke P21.
3.Na-akwalite Neurogenesis na ịkwalite Plasticity Synaptic
P21 na-emepụta microenvironment dị mma maka mmụba, iche, na nlanarị nke neurons ọhụrụ.
Mgbanwe nke ụzọ mgbaàmà akọwapụtara – OTÚ/STAT ịbụ onye isi, nwere ụfọdụ ihe akaebe maka MAPK/ERK – bụ maka mmetụta a.
Na-abawanye plasticity synapti site na mgbanwe aghụghọ dị na 'ike’ nke njikọ neuronal bụ usoro isi ihe ọzọ; Ejikọtara ikike mmụta na usoro a ozugbo.
Ụdị anụmanụ na-egosi nkwalite dị ukwuu na Ike ogologo oge (LTP) n'ime sel hippocampal, A na-emeziwanye mmụta dabere na hippocampus na ụdị ebe nchekwa dị iche iche.
P21 na-akwalite ebe nchekwa ihe dị mkpa na plasticity ụbụrụ niile.
4.Ọrụ Neuroprotective
Mweghachi nke netwọk nchekwa antioxidant intracellular bụ mmetụta edepụtara nke ọma.
Na-eme ka ọrụ mitochondrial kwụsie ike, mgbochi nke ụfọdụ ụzọ apoptotic, na-egbochi (oke oke) neuroinflammation niile na-enye aka na ọnọdụ nchebe.
Ọnwụ neuronal egosipụtara – ischemia-hypoxia ụdị, ma ọ bụ n'oge na-adịbeghị anya ọrịa Alzheimer na-eṅomi nsị – P21 nwere ike igbochi ya nke ọma.
Idokwa opekata mpe sel neuronal iguzosi ike n'ezi ihe bụ njedebe nke ahịrị nchebe a; A na-enyocha ụzọ ọgwụgwọ ọhụrụ maka ezi ọrịa neurodegenerative site na ya.
5.Iwu nke Metabolism Energy na Agụụ
Ọmụmụ ụlọ ọgwụ izizi nke CNTF gosipụtara mmetụta mbelata ịdị arọ dị ike.
P21 na-ejigide iberibe isi maka nke ahụ. Nnwale ụlọ ọgwụ na-akwado nnọgidesi ike nke mmetụta ahụ.
Ụzọ leptin-STAT3 (hypothalamic) bụ isi ihe nyocha ugbu a; A na-abawanye akara satiety.
Mbelata arọ sitere na P21 dị irè ma, nke dị mkpa, ichekwa akwara.
Mmetụta insulin na-akakwa mma, na-akwalite P21 n'ihu n'ime ọgwụgwọ dị mma maka oke ibu na neurodegeneration metụtara ya.
COA
HPLC
MS
