SYN-AKE bụ peptide sịntetịt nke na-eṅomi ọrụ nsị agwọ nke Waglerin I. Ọzọkwa., a makwaara ya dị ka peptide agwọ ma ọ bụ tripeptide dabere na agwọ (Glu-Val-Trp) .
Kpọmkwem, ọ nwere ike na-emekọrịta ihe na usoro okike nke anụ ahụ ma họrọ ejikọta ya ụdị muscle nicotinic acetylcholine anabata. N'ihi ya, nke a na-egbochi nnyefe nke acetylcholine (ACH) na-egosi ma na-egbochi nkwekọrịta nke neuromuscular nkwụsị (NMJ).N'ihi ya, nke a na-akpata mbelata ngwa ngwa nke ọgbọ wrinkles na ahịrị ọnụ ọchị. Ọzọkwa, Emeela SYN-AKE ule ụlọ ọgwụ wee gosipụta na ọ nweghị nchekwa yana bioactive.
Usoro
H-bAla-Pro-Dab-NHBn
Nọmba CAS
823202-98-8
Usoro ihe omimi
C19H29N5O3
Ibu molekụla
495.6 g/mol
1.Kedu ihe bụ SYN-AKE
SYN-AKE nwere ike ime ihe ndị na-anabata acetylcholine n'ime mkpụrụ ndụ akwara, n'ụzọ dị irè egbochi na-ekekọta nke neurotransmitters na onye nnata.Usoro mpaghara a dị nchebe ma dị mma karịa nsị botulinum 1 ma nwee ike imeziwanye wrinkles dị ike nke na-akpata site na mkpụkọ akwara ugboro ugboro.
2.Nchọpụta nyocha na SYN-AKE
(1).Ọmụmụ in vitro
Dị ka nchọpụta si kwuo,in vitro ọmụmụ egosila na SYN-AKE's IC50(ihe mgbochi mgbochi ọkara kacha) maka mmadụ nAChRs(Nicotinic acetylcholine receptor) bụ 0.18 μM, nke kachasi mkpa 70% nke ịta nke eke Waglerin-1.Ọzọkwa, na vitro, Achọpụtara obere mkpokọta SYN-AKE iji belata nzaghachi anụ ahụ mkpali akwara eletrik site 62%, nke na-egosipụta kpọmkwem ike ya igbochi mkpụkọ akwara.
(2).Ọmụmụ ụlọ ọgwụ n'ụkwụ olu
Ndị na-eme nchọpụta mere nchọpụta kpuru ìsì abụọ site n'iweta ọrụ 33 ụmụ nwanyị ndị nwere ụkwụ oke oke ma dị njọ. Ndị sonyere tinye ngwaahịa nlekọta anụ ahụ nwere 0.01% SYN-AKE.Mgbe otu ọnwa gachara, nha site na iji profilometry anya dị elu gosipụtara ihe dị ịrịba ama 32% mbelata omimi nke wrinkle na a 27% mbelata na olu wrinkle (P=0.007) tụnyere placebo otu
Na mgbakwunye,ndị nchọpụta nyochara nke ahụ 82% N'ime ndị sonyere nwere ọganihu a na-ahụ anya na wrinkles akpụkpọ ha, na enweghi mmeghachi omume ọjọọ dịka ọbara ọbara, bee, ma ọ bụ itching. Nke a na-egosikwa nchekwa na ịdị irè nke SYN-AKE.
(3).Mmetụta Mgbochi Ịka nká Synergistic
N'ọmụmụ ihe ọzọ, Ndị nchọpụta gosipụtara na SYN-AKE nwere ike ijikọta na MYMD-1 iji nweta mmetụta mgbochi ịka nká abụọ..
Ọmụmụ ihe a gosiri na SYN-AKE-MYMD nwere ike ：
- belata wrinkles
- na-akwalite ịcha ọcha akpụkpọ na vitro
- gbochie mbufụt
Ọzọkwa, ọ na-egbochi mkpụrụ ndụ ịhapụ ụdị oxygen na-emeghachi omume nke na-emebi DNA, si otú ahụ na-echebe telomerase ma nweta mmetụta mgbochi ịka nká zuru oke.
COA
HPLC
MS
