SYN-AKE is a synthetic peptide that mimics the activity of the snake toxin venom of Waglerin I.Additionally, it is also known as a snake venom peptide or snake-venom-based tripeptide (Glu-Val-Trp) .
具体的には, it can interact with the body’s natural processes and selectively bind to muscle-type nicotinic acetylcholine receptors. 結果として, this inhibits the transmission of アセチルコリン (ACh) signals and blocks the contraction of the neuromuscular junction (NMJ).その結果, this causes the instant minimization of the generation of wrinkles and smile lines.Moreover, SYN-AKE has been subjected to clinical trials and proven quite safe and bioactive.
順序
H-bAla-Pro-Dab-NHBn
CAS番号
823202-98-8
分子式
C19H29N5O3
分子量
495.6 グラム/モル
1.What Is SYN-AKE
SYN-AKE can act on acetylcholine receptors で muscle cells, effectively interfering with the binding of neurotransmitters そして 受容体.This local process is safer and more comfortable than botulinum toxin 1 and can significantly improve dynamic wrinkles caused by repeated muscle contraction.
2.Research Findings On SYN-AKE
(1).In vitro studies
According to research,in vitro studies have shown that SYN-AKE’s IC50(half maximal inhibitory concentration) for human nAChRs(Nicotinic acetylcholine receptor) is 0.18 μM, which is notably 70% of the concentration of the natural Waglerin-1.Furthermore, インビトロ, low concentrations of SYN-AKE were found to reduce the skin’s response to electrical muscle stimulation による 62%, which directly proves its ability to inhibit muscle contraction.
(2).Clinical Study on Crow’s Feet
Researchers conducted a double-blind study by recruiting 33 women who with moderate to severe crow ‘s feet.Participants applied a skincare product containing 0.01% SYN-AKE.After one month, measurements using high-resolution optical profilometry showed a significant 32% reduction in wrinkle depth and a 27% decrease in wrinkle volume (P=0.007) compared to the placebo group
Additionally,researchers evaluated that 82% of the participants had visible improvements in their skin wrinkles, and there were no adverse reactions such as redness, peeling, or itching. This further proves the safety and effectiveness of SYN-AKE.
(3).Synergistic Anti-Aging Effects
In another study, researchers proved that SYN-AKE can combine with MYMD-1 to achieve a dual anti-aging effect.
This study shows that SYN-AKE-MYMD can ：
- reduce wrinkles
- promote skin whitening in vitro
- inhibit inflammation
Moreover, it prevents cells from releasing reactive oxygen species that damage DNA, thereby protecting telomerase and achieving a comprehensive anti-aging effect.
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