SYN-AKE is a synthetic peptide that mimics the activity of the snake toxin venom of Waglerin I.Additionally, it is also known as a snake venom peptide or snake-venom-based tripeptide (Glu-Val-Trp) .
구체적으로, it can interact with the body’s natural processes and selectively bind to muscle-type nicotinic acetylcholine receptors. 결과적으로, this inhibits the transmission of 아세틸콜린 (ACh) signals and blocks the contraction of the neuromuscular junction (NMJ).따라서, this causes the instant minimization of the generation of wrinkles and smile lines.Moreover, SYN-AKE has been subjected to clinical trials and proven quite safe and bioactive.
순서
H-bAla-Pro-Dab-NHBn
CAS 번호
823202-98-8
분자식
C19H29N5O3
분자량
495.6 g/몰
1.What Is SYN-AKE
SYN-AKE can act on acetylcholine receptors ~에 muscle cells, effectively interfering with the binding of 신경전달물질 그리고 수용체.This local process is safer and more comfortable than botulinum toxin 1 and can significantly improve dynamic wrinkles caused by repeated muscle contraction.
2.Research Findings On SYN-AKE
(1).In vitro studies
According to research,in vitro studies have shown that SYN-AKE’s IC50(half maximal inhibitory concentration) for human nAChRs(Nicotinic acetylcholine receptor) is 0.18 μM, which is notably 70% of the concentration of the natural Waglerin-1.Furthermore, 시험관 내에서, low concentrations of SYN-AKE were found to reduce the skin’s response to electrical muscle stimulation ~에 의해 62%, which directly proves its ability to inhibit muscle contraction.
(2).Clinical Study on Crow’s Feet
Researchers conducted a double-blind study by recruiting 33 women who with moderate to severe crow ‘s feet.Participants applied a skincare product containing 0.01% SYN-AKE.After one month, measurements using high-resolution optical profilometry showed a significant 32% reduction in wrinkle depth and a 27% decrease in wrinkle volume (P=0.007) compared to the placebo group
추가적으로,researchers evaluated that 82% of the participants had visible improvements in their skin wrinkles, and there were no adverse reactions such as redness, peeling, or itching. This further proves the safety and effectiveness of SYN-AKE.
(3).Synergistic Anti-Aging Effects
In another study, researchers proved that SYN-AKE can combine with MYMD-1 to achieve a dual anti-aging effect.
This study shows that SYN-AKE-MYMD can ：
- reduce wrinkles
- promote skin whitening in vitro
- inhibit inflammation
Moreover, it prevents cells from releasing reactive oxygen species that damage DNA, thereby protecting telomerase and achieving a comprehensive anti-aging effect.
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