SYN-AKE

SYN-AKE Related Research

What Is SYN-AKE

SYN-AKE can act on acetylcholine receptors in muscle cells, effectively interfering with the binding of neurotransmitters and receptor.This local process is safer and more comfortable than botulinum toxin 1 and can significantly improve dynamic wrinkles caused by repeated muscle contraction.

Research Findings On SYN-AKE

 1.In vitro studies

According to research,in vitro studies have shown that SYN-AKE’s IC50(half maximal inhibitory concentration) for human nAChRs(Nicotinic acetylcholine receptor) is 0.18 μM, which is notably 70% of the concentration of the natural Waglerin-1.Furthermore, in vitro, low concentrations of SYN-AKE were found to reduce the skin’s response to electrical muscle stimulation by 62%, which directly proves its ability to inhibit muscle contraction.

 2.Clinical Study on Crow’s Feet

Researchers conducted a double-blind study by recruiting 33 women who with moderate to severe crow ‘s feet.Participants applied a skincare product containing 0.01% SYN-AKE.After one month, measurements using high-resolution optical profilometry showed a significant 32% reduction in wrinkle depth and a 27% decrease in wrinkle volume (P=0.007) compared to the placebo group

Additionally,researchers evaluated that 82% of the participants had visible improvements in their skin wrinkles, and there were no adverse reactions such as redness, peeling, or itching. This further proves the safety and effectiveness of SYN-AKE.

3.Synergistic Anti-Aging Effects

In another study, researchers proved that SYN-AKE can combine with MYMD-1 to achieve a dual anti-aging effect.

This study shows that SYN-AKE-MYMD can ：

• reduce wrinkles
• promote skin whitening in vitro
• inhibit inflammation

Moreover, it prevents cells from releasing reactive oxygen species that damage DNA, thereby protecting telomerase and achieving a comprehensive anti-aging effect.