Glycosylation, joalo ka phetoho ea bohlokoa ea kamora phetolelo ea liprotheine, e na le tšusumetso e kholo ho thepa ea liprotheine tse kang sebopeho, botsitso, antigenicity le immunogenicity. Leha ho le joalo, Mekhoa e tloaelehileng ea ho lokisa li-peptide tsa N-glycosylated hangata li itšetlehile ka ho thehoa ha li-amide bond., mokgoa o ka sitisoang ke dihlopha tse nang le asiti kapa tsa motheo tsa tshebetso, ka hona ho fokotsa likopo tsa bona. Ho hlola phephetso ena, leano la novel - mokhoa oa khetho ea sebaka sa Giese o kenyelletsoeng ke photoredox - o ile oa ntlafatsoa ho fihlela katleho ho lokisoa ha li-peptide tsa N-glycosylated..
Khatelo-pele ea theknoloji
Ho ile ha ntlafatsoa "catalyst" e ncha ea leseli ho hlokomela phetoho ea glycosylation ea li-peptide tlas'a maemo a bobebe..
Ho tlōla meeli ea mekhoa ea setso ho bafani ba glycosyl le masalla a amino acid, khokahano e nepahetseng ea lihlopha tse ngata tsa glycosyl le li-peptide e ile ea phethahala.
Ho thehiloe sethala se sebetsang hantle le se feto-fetohang bakeng sa phetoho ea photocatalytic peptide glycosylation, ho fana ka sesebelisoa se matla sa ho kopanya li-glycopeptide tse rarahaneng.
Melemo ea Setsebi
- Karabelo e khetha sebaka haholo ebile e na le orthogonal, e khona ho hlahisa li-peptide tsa N-glycosylated ka nepo.
- E khona ho fetola li-peptide tse rarahaneng tse tsoang ho liprotheine tsa tlhaho, ho kenyelletsa le li-peptide tse sebetsang ka bioloji le lithethefatsi tsa peptide.
Theknoloji ea phetoho ea photocatalytic peptide glycosylation e fana ka tharollo e ncha bakeng sa motsoako o nepahetseng oa glycopeptides., e nang le bohlokoa bo boholo ba saense le boleng ba ts'ebeliso. Nts'etsopele ea theknoloji ena e tla khothaletsa tsoelo-pele mafapheng a glycobiology, ho sibolla lithethefatsi le mahlale a thepa, hara tse ding.
