Hexapeptide-1 ke peptide e khuts'oane ea maiketsetso e entsoeng ka ntlafatso ea sebopeho sa sekhechana sa mantlha sa endo native. Hormone ea α-melanocyte-stimulating (α-MSH).
E boloka ts'ebetso ea tlhaho ea α-MSH, empa e eketsa botsitso le moamoheli khetho e nang le li-amino acid (mohlala, ho kenya methionine sebakeng sa Nle le ho hlahisa sebopeho sa D sebakeng sa Phe).
Tatelano
Nle-Ala-His-DPhe-Arg-Trp-NH2
Nomoro ea CAS
/
Foromo ea limolek'hule
C41H57N13O6
Boima ba Molek'hule
828.0
Lipatlisiso tse amanang le Hexapeptide-1
α-MSH ke peptide ea bohlokoa ea taolo ea vivo, le tatellano e fokolang e sebetsang ea "His-Phe-Arg-Trp" e hlokahalang bakeng sa ho kenya tshebetsong melanocortin receptors (Li-MCRs) e hlalositsoe 1.
Hexapeptide-1 ke katoloso ea tatellano ea mantlha e kaholimo moo Nle le Ala li kenyelletsoang ho eona. NH(₂)-pheletso, e bakang sebopeho sa hexapeptide se latelang: Nle-Ala-His-DPhe-Arg-Trp-NH₂.
Moralo ona ha o boloke feela tatellano ea matšoao a bohlokoa empa o boetse oa eketseha hydrophobicity ka Nle mme e matlafatsa botsitso ba enzymatic ka D-Phe, ka hona e bonts'a ts'ebetso e ntlafalitsoeng le halofo ea bophelo bo bolelele ka in vitro le in vivo ha e bapisoa le ea sekhechana sa matsoalloa..
Ka hoo, Hexapeptide-1 ke molek'hule ea bohlokoa ea sesebelisoa bakeng sa ho etsa lipatlisiso tsa ts'ebetso ea MCR le matšoao a amanang le kalafo..
Hexapeptide-1 e sebetsa haholo lelapeng la melanocortin receptors (MC1R, MC3R, MC4R, MC5R).
Ea tsena, MC1R e hlahisoa ka bongata melanocyte ea letlalo, keratinocyte le lisele tsa 'mele oa ho itšireletsa mafung' me ke receptor e bohareng e laolang mebala ea letlalo, ho ruruha le mokoallo.
(1).Taolo ea tlhahiso ea melanin
Joaloka agonist ea MC1R, Hexapeptide-1 e khomaretse MC1R ho kenya tšebetsong cyclase ea adenylate-kampo-PKA tsela ea pontšo.
Sena se eketsa ts'ebetso ea tyrosinase, e potlakisang ho qapa le ho tsamaisa melanin.
Mokhoa ona o habeli o etsa hore ts'ebeliso ea ona e be le merero e 'meli e bonahalang e hanyetsana: ho kganya letlalo le ho suha letlalo ka maiketsetso.
Libakeng tsa pigmentation tse hatelitsoeng feela, e ka sebelisoa ho fokotsa kotsi ea matheba, ha e kopantsoe le lisebelisoa tse ling tse khantšang maemong a khethehileng (arbutin le vithamine C).
Tšebeliso e itekanetseng, ka hlakoreng le leng, e thusa ho ba le chebahalo e boreleli ea letsatsi nakong ea ho fifala ha letlalo.
(2)Anti-inflammatory le Immune Modulation
Ts'ebetso ea MC1R e boetse e thibela NF-kB tse amanang le ho ruruha matšoao a litsela tseo, ka mor'a moo, e fokotsa tlhahiso ea lintho tse thibelang ho ruruha (mohlala, TNF-a, IL-6) ho ntlafatsa bofubelu le ho teneha ho bakoang ke UV kapa lik'hemik'hale tsa lik'hemik'hale letlalong.
Holim'a moo, Hexapeptide-1 e fetola ts'ebetso ea lisele tsa 'mele tsa ho itšireletsa mafung tse lutseng letlalong e le ho thusa ho khutlisa mekoallo e senyehileng ea letlalo..
Ka hona, e loketse bakeng sa lihlahisoa tsa ho lokisa letlalo le ka morao.
(3).Pholiso le Anti-Wrinkle
Hexapeptide-1 e bontšitsoe hore e phahame E-cadherin tlhaloso ea lipatlisiso tsa morao tjena, e khothalletsang ho khomarela pakeng tsa keratinocyte, le ho potlakisa ho hlaphoheloa ha letlalo.
Ka nako e tšoanang, e boetse e kenya tshebetsong li-fibroblasts ka tsela e sa tobang ka tsela ea pontšo ea cAMP ho susumetsa tlhahiso ea collagen le elastin.
Sena se eketsa elasticity ea letlalo le ho fokotsa mela e metle, sagging ho fihlela sephetho se seng se thibelang botsofali.
Hexapeptide-1 ke motsoako oa biology ea sebopeho le dermatology mosebetsing.
Ka phetoho e utloahalang ea tatellano ea mantlha ea α-MSH ea tlhaho, peptide ena e khuts'oane e nang le khanya, tokiso e thibelang ho ruruha le mesebetsi e mengata e thibelang botsofali.
Ho sibolloa ha eona ho fana ka mokhoa o mong ho feta metsoako ea litlolo e fumanehang hona joale mme e hlahisa maano a macha a kalafo ea lefu la pigmentary., ho etsa lifoto, le kutloisiso ea letlalo.
COA
HPLC
MOF
