Ea Mazduts,e tsejoang hape e le IBI362 kapa LY3305677, ke agonist e ncha e hahelletsoeng ka bobeli glucagon-joaloka peptide-1 receptor (GLP-1R) le glucagon receptor (GCGR). Ho sebetsa joalo ka motho ea thibelang botenya, e fokotsa boima ba 'mele, tsoekere ea mali,khatello ea mali, le bongata ba mathata a mang a amanang le botenya.
Tsoelo-pele ea motsoako ona e hahiloe holim'a kutloisiso e tebileng haholoanyane ea oxyntomodulinKarolo ea fisioloji; Hormone ea tlhaho ea mala e nang le likarolo tse peli tsa GLP-1 le ts'ebetso ea glucagon. Mazdutide ka boeona ke analoge ea maiketsetso e nkiloeng ho oxyntomodulin, e atolositsoeng acyl e mafura ketane ea lehlakore e etselitsoeng ho lelefatsa nako ea ts'ebetso (ho nolofalletsa ho noa hang ka beke).
Ho feta boima ba 'mele bo bonolo, liphuputso li bontšitse hore e matlafatsa tlhahiso ea insulin (ka litoeba), theola asiti ea uric maemo, e matlafatsa khatello ea oxidative, 'me bonyane e fokotsa ka mokhoa o itseng pathologies ea liphio.
Tatelano
Hae-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
Nomoro ea CAS
2259884-03-0
Foromo ea limolek'hule
C209H319N45O68
Boima ba Molek'hule
4563.06
Patlisiso ea Mazdutide
1.Tahlehelo ea Boima le Khatello ea Takatso
Boithuto ba libeke tse 12 bo ile ba lekola liphetoho tsa takatso ea lijo le boima ba 'mele ho litoeba tse tsamaisang mefuta e fapaneng ea mazdutide..
Bohlokoa, ho ile ha hlokomeloa ho fokotseha ho itšetlehileng ka tekanyo ea boima ba 'mele, ka litekanyetso tse phahameng tse sebetsang haholoanyane.
Likarolo tsa histological tsa lisele tsa sebete li fane ka tšehetso e eketsehileng bakeng sa phello ena – Hepatic steatosis le ho ruruha ho amanang le tsona li fokotsehile haholo.
Mazdutide-HD (foromo ea tekanyetso e phahameng) e bontšitse liphello tse matla ka ho fetisisa tsa hepatoprotective ha li bapisoa le dulaglutide.
2.Mosebetsi o Ntlafetseng oa makoloi le Boitšoaro ba Boithuto
Ho latela 30 matsatsi a tsamaiso e tsoelang pele, litoeba tse tšoaroang ka mazdutide li bontšitse ntlafatso e hlakileng ea bokhoni ba ho ithuta ho feta sehlopha sa taolo, e nang le phello e hlakileng ho feta dulaglutide.
Liteko tsa ho senyeha ha kelello li tšehetsa phello e ka bang teng ea phekolo ea mazdutide mosebetsing oa kelello..
3.Khokahano e ntlafetseng ea makoloi, Boitšoaro bo Amanang le Matšoenyeho
Teko ea beam e leka-lekaneng e bonts'itse litoeba tse tsamaisoang mazdutide li le betere haholo (ho tšela nako le sekhahla sa katleho) ho feta litoeba tsa taolo.
Liteko tse amanang le kelello le matšoenyeho li tšehetsa liphetho tsena.
4.Ho Ntlafatsa le ho Lokisa Tšenyo ea Neuronal le Lefu
The hippocampus e ameha haholo thutong le mohopolong; ts'ebetso ea kelello e hokahaneng haufi le lits'ebetso tsena.
Litlhahlobo tsa nalane ea likarolo tse senyehileng tsa hippocampal neuronal li bonts'a hore Mazdutide bonyane e fokotsa mofuta ona oa tahlehelo ea methapo..
Ho bolokoa ha lekala la dendritic le mehato e fapaneng ea letsoalo la mokokotlo le tsona li ile tsa bonoa sebakeng sa hippocampal.; litlamorao tse ikhethang tsa neuroprotective tse bonoang ho CA1(Lenaka la Ammone 1) le CA3(Lenaka la Ammone 3) libaka tse nyenyane tse nang le thahasello e khethehileng.
5.Ho Thibela Phokotso ea Myelin
Myelination ka boeona e phetha karolo ea bohlokoa thutong ea likoloi, likarabo tse ikamahanyang le mefuta eohle ea matšoao a kutlo ka maikutlo a kamehla a tikoloho.
Feletseng axonal insulation le ka tekanyo e khōlō tšehetso ea phepo e nepahetseng bakeng sa mosebetsi oa tsamaiso ea methapo e fanoa ke myelin.
Ho nchafatsa Myelin (ts'ebetso e amanang haufi-ufi le myelination ea 'nete) ke 'me e ntse e le karolo ea bohlokoa ea batho ba baholo CNS(Sistimi ea Bohareng ea Methapo) bophelo bo botle.
LFB(Luxol Fast Blue) staining senotse lesapo la mokokotlo demyelination; sehlopha sa mazdutide se bonts'itse likhetla tsa myelin tse hlophisitsoeng hantle, demyelination e fokolang haholo e le phello e tobileng ea phekolo.
Ho boloka botšepehi ba myelin hona joale ho nkoa e le sepheo se ka khonehang – ho lieha ho qala le tsoelopele butle ea Lefu la Alzheimer ho ba e 'ngoe ea lipheo tse tšepisang tsa kalafo tsa lipatlisiso tse joalo.
COA
HPLC
MOF
