P21 peptide e khetha haholo maiketsetso peptide motsoako o nang le sethibelo se phahameng sa boko. E tsoa ho lipatlisiso tse pharaletseng ka ciliary neurotrophic factor (CNTF), CNTF ka boeona ke ntho e etsahalang ka tlhaho cytokine ka har'a li-neurone; e sebetsang ka bongata neurotrophic factor.
Bo-rasaense ba ile ba sibolla, leha ho le joalo, hore sebopeho sa tlhaho sa CNTF se rarahane; bothata ba ho tšela mokoallo oa mali-boko, immunogenicity likotsi, 'me halofo ea bophelo e khutšoanyane haholo kaofela e hlahisa mathata a bohlokoa bakeng sa lipatlisiso tsa bongaka.
Tlhahlobo ea ho qhekella le liteko tse ileng tsa latela hape li lebisitse ho khethoeng ha sekhechana sa mantlha., Ac-DGGL-NH₂. Lithuto tsa in vitro li bonts'itse sekhechana sena se na le tšebetso e ngata ea mantlha ea neurotrophic, empa menyetla eohle e meng ea phekolo e ne e lekanyelitsoe ebile e ntse e lekanyelitsoe.
Litšitiso tse ka sehloohong ke ho se khone ho kenella ha boko ba mali le ho senyeha ho hoholo ka potlako ke liprotheine tsa plasma.; tlase haholo bioavailability ka vivo ke phello ea ho qetela.
Ho rarolla mathata ana, sebopeho sa tricyclic se phahameng haholo – adamantane moiety – e tsebisitsoe. Phetoho ena e atlehile ho ntlafatsa ho kenella ha P21, tšitiso ea steric ho fana ka bonyane ts'ireletso e sa fellang ea N-terminal ea peptide ho tloha protease hlasela.
E ntlafalitsoe botsitso ba metabolism 'me halofo ea bophelo e atolositsoe haholo e ile ea latela e le phello e tobileng.
Ka kakaretso, sete e ikhethang le e hlalositsoeng hantle ea litlamorao tsa methapo ea kutlo le boitšoaro e fihlelleha ka moralo oa P21.
Tatelano
Ac–asp-gly-gly-leu-adamantane-NH2
Nomoro ea CAS
/
Foromo ea limolek'hule
C27H41N5O9
Boima ba Molek'hule
579.65
Lipatlisiso tse amanang le P21 Peptide
1.Mesebetsi ea likokoana-hloko ea CNTF
Ntle le ho khothaletsa ho phela ha motor neuron, e susumetsang mefuta e fapaneng ea li-neurotransmitter synthesis, ho susumetsa khōlo ea neuronal axon, le ho sireletsa methapo ea kutlo ka bobeli le lisele tsa tsona tse tšehetsang ho excitotoxicity le mefuta e itseng ea tšenyo ea ho ruruha, CNTF e kenya tšebetsong litsela tse itseng tsa matšoao ho hypothalamus – ho khora ho eketseha e le e 'ngoe ea litlamorao tse tlalehiloeng hantle.
2.Katleho ea Meriana le Lintho tsa Neuroprotective
Liteko tsa tleliniki li bonts'itse P21 e na le ts'ebetso e holimo ea bongaka ha e bapisoa le CNTF. Hippocampal neurogeneis, mefuta eohle ea polasetiki ea synaptic, bokhoni ba ho ithuta le mefuta e fapaneng ea mathata a kelello kaofela a susumetsoa hantle.
Liphello tsa Neuroprotective (ischemia/reperfusion, neuroinflammation le khatello ea oxidative) li boetse li bonoa, le ho laoloa, ka P21.
3.Ho Khothalletsa Neurogenesis le ho Matlafatsa Plastiki ea Synaptic
P21 e theha tikoloho e ntle e nyane bakeng sa ho ata, karohano, le ho phela ha li-neurone tse ncha.
Ho feto-fetoha ha litsela tse khethehileng tsa pontšo – JOANG/STELA ho ba ka sehloohong, ka bopaki bo bong ba MAPK/ERK – e ikarabella bakeng sa phello ena.
Ho eketsa polasetiki ea synaptic ka liphetoho tse poteletseng ho 'matla’ ea likhokahano tsa methapo ea kutlo ke mokhoa o mong oa bohlokoa; bokhoni ba ho ithuta bo amana ka ho toba le mokhoa ona.
Mefuta ea liphoofolo e bonts'a lintlafatso tse kholo ho Matla a nako e telele (LTP) ka har'a lisele tsa hippocampal, Ho ithuta ho itšetlehileng ka hippocampus le mefuta e fapaneng ea mohopolo e ntse e ntlafatsoa ka lebaka leo.
Sebaka sa polokelo ea mantlha ea kelello le polasetiki ea boko bo pota-potileng li matlafatsoa ke P21.
4.Mosebetsi oa Neuroprotective
Keketseho ea marang-rang a ts'ireletso ea intracellular antioxidant ke phello e tlalehiloeng hantle.
Ho tsitsisa mosebetsi oa mitochondrial, thibelo ea litsela tse itseng tsa apoptotic, le ho hatella (feteletseng) neuroinflammation kaofela e kenya letsoho boemong ba tšireletso.
Ketsiso ea lefu la neuronal la liteko – mofuta oa ischemia-hypoxia, kapa morao tjena lefu la Alzheimer le etsisa chefo – e ka thibeloa ka katleho ke P21.
Ho boloka bonyane karolo e itseng ea botšepehi ba lisele tsa neuronal ke ntlha ea ho qetela ea mohala ona oa tšireletso; Ho ntse ho hlahlojoa mekhoa e mecha ea phekolo bakeng sa mafu a 'nete a neurodegenerative.
5.Taolo ea Matla a Metabolism le Takatso ea Lijo
Lithuto tsa pele tsa kliniki tsa CNTF li senotse litlamorao tse matla tsa ho theola boima ba 'mele.
P21 e boloka karolo ea mantlha e ikarabellang bakeng sa seo. Liteko tsa meriana li tiisa ho phehella ha phello.
Tsela ea leptin-STAT3 (hypothalamic) ke sepheo sa hajoale sa lipatlisiso; matshwao a kgora a a hodiswa.
Ho theola boima ba 'mele ho tloha ho P21 ho sebetsa hantle ebile ho, bohlokoa, ho baballa mesifa.
Kutloelo-bohloko ea insulin le eona e ea ntlafala, ho sutumelletsa P21 ho ea kalafong e ka bang hantle bakeng sa botenya le neurodegeneration e amanang le eona.
COA
HPLC
MOF
