SYN-AKE ke peptide ea maiketsetso e etsisang tšebetso ea chefo ea chefo ea noha ea Waglerin I. Ho ekelletsa moo., E boetse e tsejoa e le peptide ea chefo ea noha kapa tripeptide e thehiloeng ho chefo ea noha. (Glu-Val-Trp) .
Ka ho toba, e ka sebelisana le mekhoa ea tlhaho ea 'mele' me e khetha ho tlama ho mofuta oa mesifa ea nicotinic acetylcholine receptors. Ka hoo, sena se thibela phetiso ea acetylcholine (ACh) matshwao a medumo le dithibela thitelo ya ho kopana ha neuromuscular (NMJ).Ka lebaka leo, sena se etsa hore hang-hang ho fokotsehe ha moloko oa wrinkles le mela ea pososelo.Ho feta moo, SYN-AKE e kile ea lekoa litekong tsa bongaka mme ho netefalitsoe hore e bolokehile ebile e sebetsa.
Tatelano
H-bAla-Pro-Dab-NHBn
Nomoro ea CAS
823202-98-8
Foromo ea limolek'hule
C19H29N5O3
Boima ba Molek'hule
495.6 g/mol
1.SYN-AKE ke Eng
SYN-AKE e ka nka khato li-receptor tsa acetylcholine ho lisele tsa mesifa, ho kena-kenana ka katleho le tlamo ya li-neurotransmitters le moamoheli.Ts'ebetso ena ea lehae e bolokehile ebile e phutholohile ho feta chefo ea botulinum 1 'me e ka ntlafatsa haholo makukuno a matla a bakoang ke ho honyela ha mesifa khafetsa.
2.Liphuputso tsa Lipatlisiso ho SYN-AKE
(1).Lithuto tsa in vitro
Ho latela lipatlisiso,lithuto tsa in vitro li bonts'itse hore SYN-AKE's IC50(Half maximal inhibitory concentration) bakeng sa motho naChRs(Nicotinic acetylcholine receptor) ke 0.18 μM, e ikhethang 70% ea mahloriso a tlhaho ea Waglerin-1.Ho feta moo, ka vitro, likhahla tse tlase tsa SYN-AKE li fumanoe ho fokotsa karabelo ea letlalo ho ho tsosoa ha mesifa ea motlakase ka 62%, e pakang ka ho toba matla a yona a ho thibela ho honyela ha mesifa.
(2).Thuto ea Clinical Maotong a Lekhoaba
Bafuputsi ba entse boithuto bo sa boneng habeli ka ho thaotha 33 basali ba nang le maoto a leka-lekaneng ho isa ho a matla.Barupeluoa ba ile ba sebelisa sehlahisoa sa letlalo se nang le 0.01% SYN-AKE.Ka mora khoeli, litekanyo tse sebelisang high-resolution optical profilometry li bontšitse bohlokoa 32% phokotso ea botebo ba masoebe le a 27% ho fokotseha ha molumo oa sosoana (P=0.007) bapisoa le sehlopha sa placebo
Ho phaella moo,bafuputsi ba ile ba lekola seo 82% ea barupeluoa ba bile le lintlafatso tse bonahalang letlalong la bona le sosobaneng, 'me ho ne ho se na maikutlo a mabe a kang bofubelu, ho ebola, kapa ho hlohlona. Sena se boetse se paka polokeho le katleho ea SYN-AKE.
(3).Synergistic Anti-botsofali Liphello
Thutong e 'ngoe, bafuputsi ba pakile hore SYN-AKE e ka kopana le MYMD-1 ho fihlela phello e 'meli e khahlanong le botsofali..
Boithuto bona bo bontša hore SYN-AKE-MYMD e ka ：
- fokotsa wrinkles
- khothalletsa ho soeufala ha letlalo ka in vitro
- thibela ho ruruha
Ho feta moo, e thibela lisele ho ntša mefuta ea oksijene e sebetsang e senyang DNA, ka ho etsa joalo e sireletsa telomerase le ho fumana phello e felletseng ea ho thibela botsofali.
COA
HPLC
MOF
