SS-31 (elamipretide) bụ peptide pere mpe nke nwere anọ amino asịd; kpọmkwem ezubere iche mitochondria.
Ntinye nke oma nke akpụkpọ anụ cell bụ otu n'ime njirimara ya, na a kpọmkwem lekwasịrị anya nke n'ime mitochondrial akpụkpọ anụ.
Omenala antioxidants anaghị achịkọta nke ọma n'ime ebe a na-akpachi anya mitochondrial matrix, ngafe nfe ụdị oxygen reactive (ROS) dị ka nnukwu mgbochi.
Ụdị pụrụ iche nke SS-31 na-enye ohere maka ma neutralization nke free radicals, na iche iche electrostatic mmekọrịta/hydrophobic mmekọrịta; kpọmkwem anchoring na mitochondria n'onwe ya bụ ihe pụta kpọmkwem nke a.
Ọgwụ Mitochondrial n'ozuzu na-ahụ SS-31 dị ka otu n'ime ọgwụ ndị a na-enweta na nso nso a..
Na-agafe naanị mmetụta cytoprotective, A na-ahụkwa omume nkwughachi dị ike.
Ịkwụsị usoro ọjọọ nke nrụgide oxidative bụ ihe na-ekewa SS-31..
Na-emeziwanye myocardial ike metabolism, obere infarct nha, ọrụ obi n'ozuzu ya, na ruo n'ókè ụfọdụ, ọrụ neurodegenerative, niile dị nso.
Nkwekọrịta mmega ahụ na ike akwara na-agbakwunyere, ma dị mkpa, njedebe na SS-31 nwere ike imetụta.
Usoro
D-Arg-Dmt-Lys-Phe-NH2; Dmt=2',6'-dimethylTyr
Nọmba CAS
736992-21-5
Usoro ihe omimi
C32H49N9O5
Ibu molekụla
639.8 g/mol
Nnyocha nke SS-31
1.Ngwa Clinical na ike ọgwụgwọ
Nnwale ụlọ ọgwụ n'oge egosila mmetụta cytoprotective dị ịrịba ama – isi mitochondrial myopathies, Ọrịa Barth, obi mgbawa, nnukwu mmerụ ahụ akụrụ na akọrọ anya syndrome niile na-anọchite anya mpaghara na-ekwe nkwa nke ngwa ọgwụgwọ.
2.Mmetụta Antioxidant
A na-ekesa antioxidants ọdịnala mana dịka ekwuru n'elu enweghị ntinye a kapịrị ọnụ.
Njirimara physicochemical nke SS-31 na-enyere aka nchịkọta nhọrọ niile dị mkpa.
Nke onye inyeaka eletrọn (dimethyltyrosine) na-akpakọrịta ozugbo na neutralizes free radicals eme n'ime eletrọn njem yinye.
Nkwụsị ọkwa isi mmalite nke nrụgide oxidative bụ ebumnuche bụ isi; nchebe nke DNA mitochondrial, na-adịgide adịgide (kacha mma) mmezi nke microenvironment, na n'ezie, mmepụta ume ogologo ndụ, bụ njedebe nke ihe niile dị n'elu.
Mbelata ma ọ bụ kwụsịlata usoro ịka nká na ọtụtụ ọrịa ndị a na-apụghị ịgwọta na mbụ, bụ njedebe ikpeazụ nke usoro nyocha a.
3.Imelite ọkwa ike sistemu nke ọrịa kansa na chemotherapy mebiri
Na skeletal muscle nke ndị ọrịa cancer, mitochondrial dysfunction bụ isi ihe na-akpata ibelata Njikọ ATP; Atrophy muscle a na-apụghị ịgbagha agbagha na nrụrụ na-esote na-esote nsonaazụ ozugbo.
SS-31 na-ebelata nke ọma cachexia, na-egbochi mbelata mpaghara eriri akwara glycolytic, na-egbochi mfu mitochondrial na ụdị dị iche iche nke adịghị mma autophagy/mitosis.
Nyocha nke skeletal muscle, imeju, na metabolites plasma na-egosi mgbanwe dị ukwuu na ma ume na protein metabolism n'ime onye nnabata tumor.
4.Na-emeziwanye arụ ọrụ mitochondrial yana nsogbu ebe nchekwa jikọtara ya
Endotoxin-ụmụ oke a na-agwọ ọrịa na-egosipụta akụkụ niile nke arụrụ arụ mitochondrial a – nrụgide oxidative, nzaghachi mkpali, neuronal apoptosis, hippocampal dendritic ọkpụkpụ azụ mfu – mmụta na ike nchekwa dị mfe dị ka ihe si na ya pụta.
Nnwale na-egosi mmetụta nchebe SS-31 megide ihe ndị a kpọtụrụ aha na mbụ; modulation nke Ihe neurotrophic sitere n'ụbụrụ, ma ọ bụ aneurin BDNF na-egosi dịka ụzọ isi.
Mgbanwe nke ụfọdụ mgbanwe protein na-egosi synapti ma mụbaa (physiological) A na-ahụ mgbagwoju anya nhazi nke synapses.
Ike ọgwụgwọ maka nrụgide oxidative/neuroinflammation ụdị mmebi pụtara ìhè.
5.Na-egbochi mitochondrial permeability mgbanwe pore (mPTP) imeghe iji gbochie apoptosis
SS-31 na-edobe iguzosi ike n'ezi ihe n'ime mitochondrial membrane, site na ma antioxidant na ike ATP njikọ mmetụta.
Mee ihe ozugbo adenine nucleotide translocator (ANT) na-ebuli ọnụ ụzọ maka mitochondrial permeability mgbanwe pore / mPTP imeghe.
A na-egbochi mmalite mmalite nke usoro a nke ọma; nnukwu ọnọdụ (myocardial infarction, ọrịa strok dị ka ihe nnọchianya) enwere ike ịgwọ ma ọ dịkarịa ala akụkụ ụfọdụ site na usoro mgbochi a.
6.Mgbochi nke nzaghachi mkparị
Ihe niile dị n'elu nwere njikọ.
A na-emeziwanye ọrụ mitochondrial, mmebi na-ebelata, na mmetụta niile dị n'okpuru ala nke mbufụt na-adịghị ala ala ma ọ bụ nnukwu ọ dịkarịa ala ebelatara.
Uru ọgwụgwọ zuru oke nke SS-31 dị na ngwakọta ndị a, ma isi, omume mgbochi mkpali.
COA
HPLC
MS
