SS-31

SS-31

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SS-31

SS-31

SS-31 ke peptide e nyenyane ea molek'hule e nang le li-amino acid tse 'nè; ka ho khetheha e lebisitse mitochondria.

 

SKU: 198887 Sehlopha:
Arolelana lerato la hau

SS-31 (elamipretide) ke peptide e nyenyane ea molek'hule e nang le tse 'nè li-amino acid; ka ho toba mitochondria.

Ho kenella ka katleho ha li-membrane tsa lisele ke e 'ngoe ea likarolo tsa eona tsa bohlokoa, ka sepheo se nepahetseng sa lera la ka hare la mitochondrial.

Li-antioxidants tsa setso li hloleha ho bokellana ka ho lekaneng ka har'a tse koaletsoeng ho feta matrix a mitochondrial, ho qhekella ho feteletseng mefuta ea oksijene e sebetsang (ROS) joalo ka tšitiso e kholo.

Moralo o ikhethileng oa SS-31 o lumella ho se nke lehlakore ha li-radicals tsa mahala, le tse fapa-fapaneng litšebelisano tsa motlakase/likamano tsa hydrophobic; e khethehileng anchoring ho mitochondria ka boeona e le phello e tobileng ea sena.

Meriana ea Mitochondrial ka kakaretso e bona SS-31 e le e 'ngoe ea litlhare tse ka fumanehang haufinyane..

Ntle le litlamorao tsa cytoprotective feela, ho boetse ho hlokomeloa liketso tse matla tsa ho lokisa.

Ho senya potoloho e mpe ea nakong e fetileng ea khatello ea oxidative ke eona e khethollang SS-31..

Ho ntlafatsa boemo ba myocardial metabolism ea matla, boholo bo nyane ba infarct, mosebetsi oa pelo ka kakaretso, le ho isa bohōleng bo itseng, mosebetsi oa neurodegenerative, kaofela li ka finyelloa.

Ho mamella boikoetliso le matla a mesifa ke tlatsetso, leha ho le joalo e le ea bohlokoa, lintlha tsa ho qetela tseo SS-31 e khonang ho li susumetsa.

Tatelano

D-Arg-Dmt-Lys-Phe-NH2; Dmt=2',6'- dimethylTyr

Nomoro ea CAS

736992-21-5

Foromo ea limolek'hule

C32H49N9O5

Boima ba Molek'hule

639.8 g/mol

Lipatlisiso tsa SS-31

1.Likopo tsa Clinical le Matla a Phekolo

Liteko tsa pele tsa kliniki li bontšitse liphello tse kholo tsa cytoprotective – myopathies ea mantlha ea mitochondrial, Barth syndrome, ho hloleha ha pelo, kotsi e mpe ea liphio le "dry eye syndrome" kaofela li emela libaka tse tšepisang tsa tšebeliso ea kalafo.

2.Liphello tsa Antioxidant

Li-antioxidants tse tloaelehileng li ajoa haholo empa joalo ka ha ho boletsoe ka holimo ha li na ho kenella ho itseng.

Thepa ea SS-31 ea physicochemical e etsa hore pokello eohle ea bohlokoa e khethoe.

The mofani oa elektronike (dimethyltyrosine) ka ho toba e sebelisana le le neutralizes ea mahala radicals hlahisoang ka hare ho ketane ea lipalangoang tsa elektronike.

Tšitiso ea boemo ba mohloli oa khatello ea oxidative ke sepheo sa mantlha; tshireletso ya DNA ea mitochondrial, kamehla (lekane) tlhokomelo ea microenvironment, le hantle, tlhahiso ea matla bophelo bohle, ke pheletso ea tsohle tse ka holimo.

Ho fokotsa kapa ho emisa mekhoa ea botsofali le mefuta e mengata ea mafu a neng a sa phekolehe pele, ke sepheo sa ho qetela sa mokhoa ona oa lipatlisiso.

3.Ho ntlafatsa maemo a matla a tsamaiso a senyehileng ke mofetše le chemotherapy

Ka mesifa ea masapo ea bakuli ba kankere, ho se sebetse ha mitochondrial ke sesosa se ka sehloohong sa ho fokotseha ATP synthesis; atrophy ea mesifa e sa fetoheng le deformation e latelang e latela e le sephetho se tobileng.

SS-31 e hatella ka katleho cachexia, e thibela ho fokotseha ha sebaka sa fiber ea mesifa ea glycolytic, e thibela tahlehelo ea mitochondrial le mefuta e fapaneng e sa tloaelehang autophagy/mitosis.

Tlhahlobo ea mesifa ea masapo, sebete, le metabolites ea plasma e bonts'a liphetoho tse kholo ho matla le protheine metabolism ka har'a moamoheli oa tumor.

4.Ho ntlafatsa ho se sebetse ha mitochondrial le ho senyeha ho amanang le mohopolo

Endotoxin-litoeba tse tšoaroang li bonts'a likarolo tsohle tsa ho se sebetse ha mitochondrial – khatello ea oxidative, likarabo tsa ho ruruha, neuronal apoptosis, mokokotlo oa hippocampal dendritic tahlehelo – ho ithuta le bokgoni bo bonolo ba ho hopola e le sephetho.

Liteko li bonts'a litlamorao tsa ts'ireletso ea SS-31 khahlano le lintlha tse boletsoeng pejana; modulation of Neurotrophic factor e tsoang bokong, kapa aneurine BDNF sesupo joalo ka tsela ea bohlokoa.

Phetoho ea liphetoho tse ling tsa protheine ea synaptic le ho eketseha (fisioloji) ho rarahana ha sebopeho sa li-synapse ho bonoa.

Monyetla oa kalafo bakeng sa khatello ea oxidative/neuroinflammation tshenyo ya mofuta e bonahala.

5.Ho thibela pore ea phetoho ea mitochondrial permeability (mPTP) ho bula ho thibela apoptosis

SS-31 ka tsela e sa tobang e boloka botšepehi ba lera la ka hare la mitochondrial, ka litlamorao tse peli tsa antioxidant le tse tsitsitseng tsa ATP.

Ketso e tobileng ho adenine nucleotide translocator (NTJA) sututsa monyako bakeng sa mitochondrial permeability transition pore /mPTP bula.

Ts'ebetso e sa tloaelehang pele ho nako ea ts'ebetso ena e thibetsoe ka katleho; maemo a hlobaetsang (lefu la myocardial infarction, stroke joalo ka linyeoe tse emelang) bonyane e ka phekoloa ka mokhoa o itseng ka mokhoa ona oa thibelo.

6.Thibelo ea Karabelo ea ho Ruruhisa

Tsohle tse ka holimo li hokahane.

Mosebetsi oa mitochondrial o ntlafala, tshenyo e fokotsehile, 'me liphello tsohle tse tlase tsa ho ruruha ho sa foleng kapa tse matla li fokotsehile ka mokhoa o itseng.

Boleng bo felletseng ba kalafo ea SS-31 bo ho tsena tse kopantsoeng, leha ho le joalo ea motheo, liketso tse khahlanong le ho ruruha.

COA

HPLC

MOF

(1)Ballaro, R.; Lopalco, P.; Audrito, V.; Beltra, M.; Pin, F.; Angelini, R.; likhopo, P.; Lipere, A.; Bonetto, A.; Szeto, H. H.; le al. Targeting Mitochondria ka SS-31 E matlafatsa Boemo ba Matla a 'Mele Ohle ka Kankere- le Cachexia ea Chemotherapy-Induced Cachexia. Kankere (Basel) 2021, 13(4). DOI: 10.3390/kankere13040850 Ho tloha ho NLM PubMed-not-MEDLINE.

(2)Kai, J.; Jiang, Y.; Zhang, M.; Zhao, H.; Li, H.; Li, K.; Zhang, X.; Qiao, T. Liphello tsa ts'ireletso tsa peptide e lebisitsoeng ke mitochondrion SS-31 khahlano le leqeba la mokokotlo la ischemia-reperfusion. J Physiol Biochem 2018, 74(2), 335-343. DOI: 10.1007/s13105-018-0617-1 Ho tsoa ho NLM Medline.

(3)Dai, D. F.; Chen, T.; Szeto, H.; Nieves-Cintron, M.; Veine ea ntja, V.; Santana, L. F.; Rabinovitch, P. S. Mitochondrial e lebisitsoe ho antioxidant Peptide e matlafatsa khatello ea mali ea pelo. J Am Coll Cardiol 2011, 58(1), 73-82. DOI: 10.1016/j.jacc.2010.12.044 Ho tsoa ho NLM Medline.

(4)Ding, X. W.; Robinson, M.; Li, R.; Aldhowayan, H.; Geetha, T.; Babu, J. R. Ho se sebetse ha Mitochondrial le litlamorao tse ntle tsa peptide e nyane e lebisitsoeng ke mitochondria SS-31 ho lefu la tsoekere le lefu la Alzheimer's.. Pharmacol Res 2021, 171, 105783. DOI: 10.1016/j.phrs.2021.105783 Ho tsoa ho NLM Medline.

(5)Liveine tse monate, M. T.; Pippin, J. W.; Eng, D. G.; Hudkins, K. L.; Chiao, Y. A.; Campbell, M. D.; ka Marcin, D. J.; Alpers, C. E.; Szeto, H. H.; Rabinovitch, P. S.; Shankland, S. J. Peptide e lebisitsoeng ho mitochondrial, SS-31, e ntlafatsa meralo ea glomerular ho litoeba tsa botsofali. Liphio Int 2017, 91(5), 1126-1145. DOI: 10.1016/j.kint.2016.10.036 Ho tsoa ho NLM Medline.

(6)Szeto, H.; Zhang, Y.; Nakagawa, Y.; sefate sa eike, C.; Botala, S.; Deng, X.; Rodeo, S.; Zhang, X. Tlhahlobo ea SS-31 e le Sepheo se ka khonehang sa Phekolo ea Phekolo ea Tendinopathy. Orthopedic Journal of Sports Medicine 2020, 8(7_tlhahiso6). DOI: 10.1177/2325967120s00395.

(7)Zhang, H.; Chen, Y.; Li, F.; Wu, C.; Kai, W.; Ee, H.; Ke, H.; Eena, M.; E leng, L.; Wang, X.; le al. Elamipretide e fokotsa pyroptosis mokokotlong oa mokokotlo o lemetseng hampe ka ho thibela cPLA2-induced lysosomal membrane permeabilization.. J Neuroinflammation 2023, 20(1), 6. DOI: 10.1186/s12974-023-02690-4 Ho tsoa ho NLM Medline.

(8)Zhao, W.; Xu, Z.; Cao, J.; Fu, Q.; Wu, Y.; Zhang, X.; Nako e telele, Y.; Zhang, X.; E leng, Y.; Li, Y.; Mi, W. Elamipretide (SS-31) e ntlafatsa ho se sebetse ha mitochondrial, Synaptic le ho senyeha ha mohopolo ho bakoang ke lipopolysaccharide ho litoeba. J Neuroinflammation 2019, 16(1), 230. DOI: 10.1186/s12974-019-1627-9 Ho tsoa ho NLM Medline.

Tatelano:

D-Arg-Dmt-Lys-Phe-NH2; Dmt=2',6'-dimethylTyr
CAS:

736992-21-5
M.W:

639.8 g/mol

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