Crystagen is a crucial bio-regulatory peptide primarily designed to enhance the body’s immune regulatory capacity. Systematic exploration of thymus function and its secretory substances led to its synthesis through highly deliberate design.
Since discovery, multi-level, multi-target biological regulatory capabilities have been demonstrated for Crystagen. The core efficacy lies in significantly and precisely improving various aspects of immune system function.
Immunomodulatory power specifically comes from positive regulation of specific T lymphocyte subsets – helper Th cells being the prime example, along with cytotoxic T cells; stimulation of their proliferation, activation, and subsequent secretion of effector molecules is central to this process.
B-cell related activation and humoral immunity is also modulated, synergistically completing the immune response.
Mimicking endogenous immune signaling molecules itself is one of Crystagen’s key mechanisms; ligand-receptor type interactions on the surface of immune cells initiate intracellular pathways.
Some clinical studies have reported a direct anti-inflammatory effect, reducing the various forms of immune stress damage the body incurs.
Normalization of microenvironmental states is a desired end point.
Potent immunomodulation (current and future) is what Crystagen aims to achieve.
序列
Glu-Asp-Pro
化学文摘社编号
/
分子式
C14H21N3O8
分子量
359.335
Research Of Crystagen Peptide
1.Regulating lymphocytes
Direct action on cellular immune responses is Crystagen’s primary focus.
Faster, more effective activation and the full range of proper differentiation into functional effector T cells upon antigen encounter are all part of this process.
2.Modulation of (programmable) immune signaling
As mentioned above, all of the previous points lead to a programmed activation of the immune system.
Immune cells can and will change their state in response to Crystagen.
3.Cell Protection and Homeostatic Maintenance
Crystalgen mitigates oxidative stress damage specifically to immune cells.
Upregulation of various intracellular antioxidants (glutathione being a prime example) is the primary mechanism of action in this process.
Simultaneously, inhibition of the mitochondrial apoptosis pathway – through regulated expression of the Bcl-2 family proteins – is observed; reduced apoptosis of these cells directly leads to longer survival times and subsequent functional endurance.
Maintaining a stable microenvironment within the body is another key property Crystalgen exhibits.
Regulating (and restoring) the proper proportion of different immune cell subsets is how these more global immune functions are re-established: surveillance, active defense, and clearance functions.
Cancer adjuvant therapy is one of the more desirable end applications of this line of immune protection.
COA
高效液相色谱法
MS
