Acetyl Tetrapeptide-15 sitere na ya endomorphin-2 site na a acetylation mgbanwe na N-terminal ya tyrosine foduru. A na-ejikarị mgbanwe kemịkalụ a kapịrị ọnụ iji kwalite nkwụsi ike peptide ma ọ bụ gbanwee ọrụ ndu ya.
Endomorphin-2 n'onwe ya bụ agonist endogenous edekọtara nke ọma yana oke mmekọrịta yana nhọrọ maka ndị na-anabata μ-opioid (MOR) dị ka njirimara nkọwa ya. N'ihi myirịta ya na ogige nne na nna a, A na-eche na acetyl Tetrapeptide-15 nwere ihe fọrọ nke nta ka ọ bụrụ otu ọrụ ndụ.
Nke mbụ, na ụbọchị nso naanị, Ngwa nke peptide acetylated a dabara n'ime ụlọ ọrụ ịchọ mma – Ngwaahịa akpụkpọ anụ dị nro bụ ihe atụ kachasị ewu ewu nke iji ya dị ka ihe na-arụ ọrụ.
Usoro
Ac-Tyr-Pro-Phe-Phe-NH2
Nọmba CAS
928007-64-1
Usoro ihe omimi
C34H39N5O6
Ibu molekụla
613.70 g/mol
Nnyocha nke Acetyl Tetrapeptide-15
Mmepe nke acetyl tetrapeptide-15 bu n’obi ibuli oke mkpali nke μ-opioid receptor-na-egosipụta neurons.; endorphin-dị ka usoro a na-eji. Ịkwalite nnabata anụ ahụ na mkpali dị iche iche dị na mpụga yana ibelata mkpasu iwe, na-adịghị ala ala na ọbụna neuropathic mgbu metụtara hyperreactivity akpụkpọ bụ ihe a chọrọ njedebe njedebe.
1.Na-emegharị mwepụta CGRP
CGRP (peptide metụtara mkpụrụ ndụ calcitonin) bụ neuropeptide pro-inflammatory dị ike. Neron sensọ na-ahapụ ya, vasodilation na-esote na-acha uhie uhie / edema bụ ngosipụta abụọ kpọmkwem nke uche a. Mmetụta anụ ahụ na nzaghachi mkpali metụtara bụ opekata mpe nke CGRP na-elekọta ya.
Ịkwalite onye na-anabata TRPV1 (capsaicin, ikpo ọkụ, ihe ndị na-emebi emebi niile na-arụ ọrụ dị ka ihe na-akpalite) na-eduga ná ntọhapụ ya. jikọrọ ọnụ neurons sensọ emeso ya na acetyl tetrapeptide-15 gosipụtara mgbochi dị ukwuu nke ma capsaicin na Potassium chloride (KCl, ma ọ bụ potassium nnu) ewepụtara CGRP ntọhapụ – mmetụta na-atụnyere, ma ọ bụ mma karịa, TRPV1 antagonist capsazepine mara amara.
2.Ntinye nke μ-Opioid Nnabata
Na nyocha in vitro: N'ime ụdị mkpali capsaicin, acetyl tetrapeptide-15 jikọtara ọnụ na ndị na-anabata μ-opioid na neurons sensọ.. Ejiri naloxone onye na-emegide opioid na-akwado njikọ a.
Capsaicin n'onwe ya na-ejikọta na ndị na-anabata TRPV1, na-akpali mbanye calcium; Mwepụta CGRP na-esote na mgbaàmà mgbu na-esochi ya. acetyl tetrapeptide-15 belatara nke ukwuu ntọhapụ CGRP nke capsaicin na-akpali, mmetụta mgbochi nke naloxone na-enye nkwenye dị mkpa nke ntinye aka nke nnabata.
Ịrụ ọrụ μ-receptors ndị a na-enye ohere acetyl tetrapeptide 15 iji megharịa ọrụ neuron sensory na-adịghị mma; neuropeptides pro-inflammatory (CGRP bụ ezigbo ihe atụ) a na-esi otú ahụ na-erughị atọhapụ. Igbochi mbufụt neurogenic na isi iyi ya bụ njedebe njedebe na-egbu egbu, na-atọ ụtọ ịbụ onye ọzọ.
3.Ọmụmụ ụlọ ọgwụ
Nnwale ụlọ ọgwụ kpuru ìsì nyochara ikike acetyl tetrapeptide-15 iji belata mmetụta anụ ahụ.. A na-etinye mkpokọta capsaicin na-abawanye n'ime ya nasolabial fold (ọnụ erughị ala bụ ihe atụ nke mmasị), na ntì contralateral na-eje ozi dị ka njikwa ụgbọ ala.
Ngwa peptide ugboro ugboro, na 0.0015%, ugboro abụọ kwa ụbọchị maka ụbọchị anọ, sochiri ihe ịma aka capsaicin ọzọ, gosiri mmụba doro anya na nke a pụrụ ịtụtu ọnụ na ọnụ ụzọ ahụ.
Ugbu a ngwa nke acetyl tetrapeptide-15 ka bụ nke ukwuu na usoro ịchọ mma.. Isi mgbochi mmetụta bụ ihe ọ na-enye; ngwaahịa akpụkpọ anụ (ka ụbọchị dịkarịa ala) buru nke a n'uche.
A na-ebelata ọkụ na ịta ahụhụ, na ruo n'ókè, Enwere ike nweta ụdị ahụ erughị ala ma ọ bụ nso-normalization nke anụ ahụ. Ihe mgbakasị ahụ ọhụrụ na ma ọ bụ ihe mgbochi mkpali bụ nzọụkwụ na-esote ezi uche dị na ya, na acetyl tetrapeptide-15 nwere ikike na sayensị dermatological ma ọ bụ ịchọ mma n'ọdịnihu.
COA
HPLC
MS
