Hexapeptide-10

Hexapeptide-10, or more formally referred to as SIKVAV/Serilesine, is the smallest functional unit precisely isolated from the globular domain of the laminin α1 chain. Exceptionally high biological activity is a defining characteristic of this peptide.

Early studies have shown greater cell adhesion-promoting and, to a large extent, axonal growth-stimulating capabilities when compared to intact laminin. Specific recognition and subsequent activation of various integrins and other surface receptors is another key property; cell proliferation, differentiation, and survival all follow as direct consequences.

Within neuroscience, therapeutic potential for repairing damage to the central or peripheral nervous system is well documented. The cosmetic field has recently seen a significant rise in its prominence.

Hexapeptide-10, given its neuromodulatory and tissue-repairing potential, is a vital component of both cosmetic and dermatological science.

这是测试文本，单击 “编辑” 按钮更改此文本。

序列

H-Ser-Ile-Lys-Val-Ala-Val-OH

化学文摘社编号

146439-94-3

分子式

C28H53N7O8

分子量

615.77

Hexapeptide-10 Related Research

1.Skin Repair and Homeostasis Regulation

Extensive grafting or surface modification of biomaterials with Hexapeptide-10 allows for the induction of stem cell differentiation, fibroblast/endothelial cell proliferation and directed migration – thereby accelerating skin wound healing.

Precise regulation of keratinocyte proliferation-differentiation balance is what sets it apart; excessive basal layer epidermal proliferation is moderated, promoting orderly division of the stratum corneum.

Skin structural strength and overall integrity are improved, texture being a primary concern. Neural signaling pathways are also modulated, reducing skin’s sensitivity to external stimuli; sensitive skin in particular benefits from all of the above.

2.Regulating keratinocyte proliferation and differentiation to maintain skin homeostasis

Hexapeptide-10 directly acts on epidermal cells, balancing their proliferation and subsequent differentiation.

Inhibiting irregular differentiation and uncontrolled division within the basal layer, it upregulates the gene expression of terminal differentiation-associated proteins. Cellular differentiation disorders resulting from aging, environmental stress, or specific skin conditions are thus effectively counteracted.

A more complete, functionally robust physical barrier is formed; increased hydration of the skin is a direct result, smoother and refined complexion being the end point of this process.

3.Sensitive Skin Regulation and Relief of associated Itching/Discomfort

Interaction with receptors on sensory neurons is the key mechanism; modulating ion channels thereby regulates neural excitability.

Pro-inflammatory factor secretion is inhibited, and an elevated sensory threshold leads to significant reduction or elimination of burning, stinging, itching and tightness. Long term environmental stress tolerance is thereby maintained at this neural level.

4.Promoting Axonal Growth and Neural Repair

Specific neuronal surface receptors are the targets of Hexapeptide-10.

This triggers intracellular cascades (Focal Adhesion Kinase and Src family kinases) that activate downstream gene expression pathways for growth and differentiation. Cytoskeletal protein synthesis and reorganization is upregulated within the neuron itself.

Biomaterial studies have shown regenerating axons to follow defined scaffold orientations, re-establishing connectivity with target tissues. Neural and skin tissue repair is a direct outcome of these processes.