Oligopeptide-24

Oligopeptide-24 Related Research

1.Upregulating Elastin Functionality

Mimicking the physiological role of endogenous elastin, it significantly upregulates elastin synthesis within the dermis; skin elasticity, firmness, and hydration are all improved.

Plumped tissue, smoothed fine lines, and overall positive changes in texture are direct results of this process.

Direct stimulation of fibroblasts (proliferation and activity) leads to increased collagen synthesis – healthier , more youthful skin being the end result.

Upon entering the skin via delivery systems, Oligopeptide 24 binds to specific receptors on fibroblast surfaces.

Elastin signaling is mimicked, intracellular pathways being activated; the transcription of the elastin gene itself is the primary focus.

Skin firmness and suppleness are greatly enhanced, compensating for the well-documented decline (photoaging) causes to natural elastin production.

Generation of the ‘source’ proteins is what truly restores aged skin to a more youthfulness.

2.Activates Fibroblast Activity and Stimulates Collagen Synthesis

As mentioned above, direct targeting of fibroblasts is one of the key effects Oligopeptide 24 exerts.

It enhances overall metabolic activity of fibroblasts, stimulating their division and proliferation.

It promotes rapid migration to damaged areas, enhancing their functional state in synthesizing extracellular matrix and stimulating production of more Type I and III collagen, further consolidating the skin’s firmness framework.

The skin’s self-repair and regenerative capabilities are improved, resulting in a healthier appearance.

3.Strengthens Skin Barrier and Hydration Function

Oligopeptide 24 activates the integrin α6β4→PI3K→Akt axis, stimulating keratinocytes to secrete filaggrin and loricrin, and upregulating the expression of tight junction proteins claudin-1 and occludin.

This effectively strengthens the structural integrity between dermal and epidermal cells, enhances skin moisturizing function, and makes the stratum corneum more intact.

4.Antioxidant and Post-Procedure Repair

Cysteine residues provide recyclable sulfhydryl groups that donate electrons to free radicals, scavenging reactive oxygen species.

Via the Nrf2/ARE pathway, it induces the expression of multiple antioxidant enzymes (HO-1, SOD2, GCLC); blocking the lipid peroxidation chain reactions inherent in many forms of skin damage.

Clinical studies have shown a decrease in skin pigmentation (approximately 12%) and an increase in radiance after continuous 8 week use.

Cysteine itself forms temporary occlusive gels with free aldehydes present on wound surfaces, rapidly sealing microchannels and thus shortening the inflammatory cycle.

Upregulation of VEGF and TGF-β3 promotes granulation tissue formation, while the scarfibrotic TGF-β1 signaling is also inhibited.