Usoro cellular mbụ
Isi mmalite nke ịka nká mmadụ bụ senescence cellular, mkpụrụ ndụ senescent ruo mgbe ebighị ebi pụọ na okirikiri cell, ma a gaghị ewepụ ha ozugbo dị ka mkpụrụ ndụ apoptotic, mkpụrụ ndụ senescent n'ozuzu nwere ọnụ ọgụgụ buru ibu nke DNA mebiri emebi, nke nwere ike ịbụ ihe kpatara na anaghị ewepụ ha, ya mere mkpụrụ ndụ senescent ga-abụ ọnụ ọgụgụ buru ibu nke echekwabara, ma na-aga n'ihu na-edebe ya si otú ahụ na-ebute ịka nká nke ahụ na ihe omume nke ọrịa ndị metụtara ya. (Tupu mkpụrụ ndụ senescent egbu gị, i kwesịrị ibu ụzọ tie)
Mkpụrụ ndụ p53 nwere ọrụ nke ịkpata apoptosis, na usoro ya bụ na protein p53 nke mkpụrụ ndụ p53 kpuchiri ya na-arụ ọrụ dị ka ebe nlele na usoro G1 nke okirikiri cell na ọ bụ ya na-ahụ maka ịlele ma enwere mmebi na DNA chromosomal.; ozugbo a chọtara DNA nwere nkwarụ, ọ na-akpali nkwupụta nke CIP, nke na-egbochi mkpụrụ ndụ ịbanye n'ime okirikiri cell ma malite usoro nhazi DNA; ọ bụrụ na nrụzi ahụ ada ada, p53 na-ebute usoro apoptosis.
N'ime sel anụ ahụ, Okwu FOXO4 na-ebili ma na-emetụta usoro nke senescence cell na apoptosis site na mmekọrịta ya na protein dị ka p53.. N'ihi na ọ na-ejikọta na p53, ọ nwere ike igbochi ọnwụ sel sesescent.
Ọdịiche dị n'etiti FOXO4 na FOXO4-Dri
FOXO4 peptide mkpụmkpụ bụ ụdị amino acid L.
FOXO4-Dri peptide mkpụmkpụ bụ ụdị amino acid D.
Gịnị kpatara FOXO4-Dri pụtara
FOXO4 bụ polypeptide kwụ ọtọ nke mejupụtara 46 amino asịd, Ọtụtụ n'ime usoro a bụ amino acid nke ụdị D, n'ihi na o jikọtara ya na p53 gene, na-egbochi okwu nke p53 gene, si otú a na-eduga na enweghị ike iwepụ mkpụrụ ndụ senescent.
N'echiche mbụ, ndị ọkà mmụta sayensị chọrọ iji edezi mkpụrụ ndụ ihe nketa wepụta mkpụrụ ndụ foxo4, ma nke a bụ oke ọrụ na ọ na-enwekarị mmebi DNA. Ya mere, ndị ọkà mmụta sayensị chepụtara ụzọ ọzọ site n'iji ụdị amino asịd D dochie ụdị amino asịd L niile dị na FOXO4 peptide mkpụmkpụ., nke na-atụgharị ngbanwe nke FOXO4-Dri ma na-ejikọ aka na p53, mgbe ị na-egbochi FOX04 ijikọ na p53.
P53 na-arụ ọrụ protein apoptotic ma na-akpata ọnwụ cell. Site na iwepu sel ochie na anụ ahụ, enwere ike nweta mmeghari anụ ahụ dị egwu karị.
Mgbakwunye: ụmụ oke anụ ahụ etinyere na FOX04-dir gosipụtara mmụba dị ukwuu na ọrụ akụrụ na ntutu malitere ịrụzi onwe ya.
