Pentapeptide-3 (Vialox®) bụ peptide sịntetịt nke na-arụ ọrụ dị ka ihe na-egbochi wrinkle.
Ihe mere ya bụ ajụala ụlọ nsọ (Tropidolaemus wagleri) venom peptide.
Usoro a bụ ihe ndabere maka ojiji a na-ewu ewu na ihe ịchọ mma iji belata wrinkles akpụkpọ na laxity.
Usoro
Gly-Pro-Arg-Pro-Ala-NH2
Nọmba CAS
135679-88-8
Usoro ihe omimi
C21H37N9O5
Ibu molekụla
495.58
Nnyocha metụtara Pentapeptide-3
1.Profaịlụ na mmepe nke ọgwụ
Ọ na-egosipụta nke ukwuu belatara nsi (ihe dị ka 1,000-fold) ma e jiri ya tụnyere venom peptide ọ na-eṅomi na njide ndị na-anabata acetylcholine.
Ọ bụ onye na-asọ mpi nke onye na-anabata acetylcholine na ọrụ site na igbochi nnyefe neuromuscular., na-eduga ná mbelata nke anụ ahụ.
Ekwuru na Pentapeptide-3 nwere ụdị omume yiri nke Tubocurarinine, nsi nke ahụ mkpọnwụ akpọnwụ nke ukwuu enwetara n'ọtụtụ osisi.
N'adịghị ka mmịpụta kpọmkwem site na nsị agwọ, A na-emepụta pentapeptide-3 na-ere ahịa n'ahịa site na usoro kemịkalụ.
Nke a bụ iji mesie ike ịdị ọcha na nchekwa ya, igbochi ihe egwu jikọtara ya na ihe ndị ọzọ na-emerụ ahụ a na-ahụ na venom eke.
2.Usoro mmemme zuru oke
Usoro izizi maka pentapeptide-3 bụ igbochi NMJ na-egosi.
N'okpuru ọnọdụ ọrụ nkịtị, mkpali ụjọ na-abata na njedebe akwara moto hapụ a neurotransmitter A maara dị ka acetylcholine.
A na-ahapụ acetylcholine, na-agafe synapse ma jikọta ya ndị na-anabata nicotinic acetylcholine (nAChR) na akpụkpọ anụ cell muscle (akpụkpọ postsynaptic).
Njikọ a na-eduga na ịgbalite ọwa ion nnabata, nke na-ekwe ka ions Na+ banye.
Nke a na-ebutekwa ya depolarization nke akpụkpọ ahụ sel anụ ahụ ma na-eduga na mgbanwe biochemical nke na-ebute mkpụkọ eriri akwara.
Pentapeptide-3 bụ onye mmegide na-asọmpi nke anụ ahụ nicotinic acetylcholine nnabata. (nAChR), na-egbochi njikọ nke acetylcholine na ndị na-anabata ndị a.
Omume a na-egbochi oghere nke Ọwa sodium voltaji, N'aka nke ya na-egbochi depolarization nke akpụkpọ ahụ postsynaptik ma na-ebute mbelata ugboro ugboro na ike nke mkpụkọ akwara..
3.Na Vitro na Clinical arụmọrụ
Nnwale in vitro egosila mbelata mkpụkọ akwara site na 71% mgbe nanị otu nkeji na ihe mgbochi ọnụego nke 58 pasent mgbe awa abụọ gachara.
Nyere na ihu wrinkles na-etolite site na mkpirisi akwara subcutaneous ugboro ugboro, usoro a nwere ike mee ka akwara dị n'okpuru akpụkpọ ahụ kwụsịlata iji belata omimi nke wrinkles na-agbanwe agbanwe, dị ka ukwu akwa.
A na-eji Pentapeptide-3 eme ihe na nlekọta anụ ahụ na-egbochi ịka nká.
A kwadoro ịdị irè ya n'ọtụtụ ule ụlọ ọgwụ.
COA
HPLC
MS
