Pentapeptide-3 (Vialox®) ke peptide ea maiketsetso e sebetsang joalo ka motsoako o thibelang wrinkles.
Moqapi oa eona o ne o susumetsoa ke noha ea tempele (Tropidolaemus oagleri) chefo peptide.
Mochini ona ke motheo oa tšebeliso ea ona e tsebahalang ho litlolo ho fokotsa makhopho a letlalo le botsoa.
Tatelano
Gly-Pro-Arg-Pro-Ala-NH2
Nomoro ea CAS
135679-88-8
Foromo ea limolek'hule
C21H37N9O5
Boima ba Molek'hule
495.58
Lipatlisiso tse amanang le Pentapeptide-3
1.Boemo ba Pharmacological le Nts'etsopele
E shebahala e fokotsehile haholo chefo (hoo e ka bang ka makhetlo a 1,000) bapisoa le peptide e chefo eo e e etsisang ka ho tlama ho li-receptor tsa acetylcholine.
Ke mohanyetsi oa tlholisano oa receptor ea acetylcholine mme e sebetsa ka ho thibela phetiso ea neuromuscular., ho lebisa ho fokotseheng ha mesifa.
Pentapeptide-3 ho thoe e na le mokhoa oa ts'ebetso o ts'oanang le oa tubocurarine, chefo e chefo e feteletseng e shoeleng litho e fumanoang limeleng tse ngata.
Ho fapana le ho ntša ka ho toba mahloko a noha, pentapeptide-3 e rekisoang e etsoa ka mokhoa oa lik'hemik'hale.
Sena ke ho netefatsa bohloeki le polokeho ea eona, ho thibela likotsi tse amanang le lintho tse ling tse kotsi tse fumanoang mahlokong a tlhaho.
2.Mokhoa o Felletseng oa Ts'ebetso
Mokhoa oa mantlha oa ts'ebetso ea pentapeptide-3 ke ho thibela NMJ pontsho.
Tlas'a maemo a tloaelehileng a tshebetso, methapo ea kutlo e fihlang methapong ea methapo ea methapo e lokollang a neurotransmitter e tsejoang ka hore ke acetylcholine.
Acetylcholine e lokolloa, tšela synapse le tlama ho nicotinic acetylcholine receptors (naCHR) holim'a lera la lisele tsa mesifa (lera la postsynaptic).
Tlamahano ena e lebisa ho ts'ebetsong ea liteishene tsa receptor ion, e lumellang Na + ions ho kena.
Sena se fella ka hore depolarization ea lera la lisele tsa mesifa 'me e lebisa liphetohong tsa lik'hemik'hale tse etsang hore mesifa ea mesifa e fokotsehe.
Pentapeptide-3 ke mohanyetsi oa tlholisano oa mesifa ea nicotinic acetylcholine receptor. (naCHR), ho thibela ho tlama ha acetylcholine ho li-receptor tsena.
Ketso ena e thibela ho buloa ha liteishene tsa sodium tse nang le voltage-gated, ka lehlakoreng le leng, ho thibela depolarization ea lera la postsynaptic mme ho baka ho fokotseha ha maqhubu le matla a ho honyela ha mesifa..
3.In Vitro le Clinical Efficacy
Liteko tsa in vitro li bontšitse ho fokotseha ha mesifa ea mesifa ka 71% ka mor'a motsotso o le mong feela le sekhahla sa thibelo ea 58 peresente kamora lihora tse peli.
Ho fanoe ka hore wrinkles sefahlehong ba ntshetswa pele ke ho pheta-pheta contraction ea subcutaneous mesifa, mokhoa ona o ne o ka phomola mesifa ea subcutaneous ho fokotsa botebo ba wrinkles e matla, joalo ka maoto a lekhoaba.
Pentapeptide-3 e sebelisoa haholo molemong oa ho thibela botsofali.
Ho sebetsa ha eona ho netefalitsoe litekong tse ngata tsa bongaka.
COA
HPLC
MOF
