Myristoyl Pentapeptide-8 is a bioactive cosmetic peptide synthesized through the chemical modification of a natural signaling sequence.
Its unique hair growth and various cosmetic functions are attributed to a specific conserved pentapeptide fragment, Lys-Thr-Thr-Lys-Ser, derived from the α1 chain of type I procollagen.
Its defining action is to stimulate dermal fibroblasts , thereby initiating a subsequent cascade that promotes the synthesis of both collagen and fibronectin.
However, rapid enzymatic degradation presents a significant barrier to its practical therapeutic application.
To overcome this, researchers have modified the peptide by conjugating it with a fatty acid chain. This modification preserves the original charge characteristics while greatly improving compatibility with the intercellular lipids of the stratum corneum.
Consequently, the modification extends the peptide’s half-life and significantly improves its transdermal penetration efficiency.
In summary, this peptide achieves potent cosmetic efficacy, securing its place in premium skincare formulations.
序列
Lys-Thr-Thr-Lys-Ser (KTTKS)
化学文摘社编号
2305730-23-6
分子式
C37H71N7O10
分子量
774.01
Myristoyl Pentapeptide-8 Related Research
1.Dermal-Epidermal Junction and Skin Structure Enhancement
Experimental evidence shows that Myristoyl Pentapeptide-8 mimics the biological signaling of laminin-5, thereby reinforcing and repairing the structure and function of the dermal-epidermal junction (DEJ).
It stimulates dermal fibroblasts to synthesize and assemble key basement membrane components, including collagen I, III, and elastin.
The end result is the fortification of the skin’s internal architecture, which reduces the depth and number of wrinkles (with loss of elasticity being a major contributing factor), leading to firmer and overall healthier-looking skin.
It also positively influences keratinocyte differentiation and keratin polymerization.
2.Direct Promotion of Dermal Collagen Regeneration
As mentioned, the peptide binds to and activates the LDL receptor-related protein (LRP/LDL receptor-related protein) on the fibroblast surface, triggering the aforementioned effects.
3.Regulation of the Hair Follicle Growth Cycle
Myristoyl Pentapeptide-8 activates the β-catenin/LEF1 signaling pathway within dermal papilla cells.
This action inhibits BMP4-induced regression signals, thereby directly prolonging the anagen (growth) phase of the hair follicle.
Experimental evidence from a mouse model of androgenetic alopecia supports this mechanism; continuous application for 21 days led to synchronized increases in eyelash, eyebrow, and scalp hair densities.
4.Enhancement of Skin Barrier Function and Antioxidant Activity
The unique structure of Myristoyl Pentapeptide-8 provides enhanced stability, with the myristoyl moiety itself inducing steric hindrance.
It lowers the activation threshold for inflammatory factors, thereby improving the skin’s resilience to environmental stress.
It supports normal epidermal cell differentiation and its metabolic cycle.
Furthermore, it promotes the synthesis of key lipids (including ceramides) within the stratum corneum, ultimately reinforcing the physical barrier and creating an optimal skin environment.
The long-term result is improved skin stability.
COA
高效液相色谱法
MS
评价
目前还没有评价