Palmitoyl Hexapeptide-12

Research Of Palmitoyl Hexapeptide-12

Palmitoyl Hexapeptide-12 itself is an elastin fragment; the direct stimulation of collagen, elastin, fibronectin, and glycosaminoglycan syntheses is its primary mechanism. Improved skin elasticity and firmness – the end desired anti-aging effect – result from this process.

Two closely interconnected pathways are responsible for these anti-aging properties: promoting the aforementioned structural protein synthesis, and to a large extent inhibiting inflammation-induced matrix degradation.

Mimicking said elastin fragments, Palmitoyl Hexapeptide-12 sends these specific biological signals to dermal fibroblasts. Research has shown enhanced migration and (to a point) proliferation of these fibroblasts.

Fibroblasts are the ‘factories’ of the primary structural components of the skin; increased activity of them is the true foundation of skin rejuvenation. Activated fibroblasts massively re-synthesize the aforementioned macromolecules.

Rebuilding dermal structures (degraded by both time and UV) is the end result, macroscopically observed as lessened wrinkles, improved firmness and all related elastic properties.

A double-blind study using a lightweight emulsion with 4% of the peptide was conducted on 10 female volunteers; elasticity, complexion, perceived fatigue and simple ‘firmness’ all improved.

Reduction of IL-6 production is another quality Palmitoyl Hexapeptide-12 exhibits, key skin cells being affected by external stimuli (UV being the most common).

Maintaining or re-establishing a certain level of homeostasis in the dermis is one of the more ideal end goals of anti-aging treatment.

Palmitoyl Hexapeptide-12 is a well thought out, and to date very successful, bioactive lipopeptide.